Abstract
Alveolar hypoventilation is known to occur in myxedema. Reduction of hypercapnic ventilatory drive has not been reported, up to now, in patients with short-term hypothyroidism. Eleven patients with short-term hypothyroidism, before and after L-triiodothyronine (L-T3) replacement therapy, and 10 normal controls were studied. Hypercapnic ventilatory drive was assessed by the evaluation of the relation between the response of ventilation and mean expiratory flow to CO2 rebreathing and by the evaluation of ventilation and mean expiratory flow at a fixed level of carbon dioxide. In patients with short-term hypothyroidism these parameters were reduced as compared with normal controis and returned to normal after L-T3 replacement. We conclude that hypercapnic ventilatory drive is blunted by short-term hypothyroidism and normalizes following replacement therapy.
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References
Koenig M.P., Scherrer M. Respiratory functional abnormalities in hypothyroidism. In: Robbins J. and Braverman L.E. (Eds.), Thyroid research. Excerpta Medica, Amsterdam, 1976, p. 527.
Wilson W.R., Bedell G.N. The pulmonary abnormalities in myxedema. J.Clin. Invest. 39: 42, 1960.
Buchanan K.D., McKiddie M.T., Reid V.M. Respiratory acidosis in hypothermic myxedema coma. Postgrad. Med. J. 43:114, 1967.
Zwillich C.W., Pierson D.J., Hofeldt F.D., Lufkin E.G., Weil J.V. Ventilatory control in myxedema and hypothyroidism. N.Engl. J. Med. 292:662, 1975.
Pacini F., Vitti P., Ambrosino N., Martino E., Lippi F., Giani C., Ceccarelli C., Miccoli P., Pingitore R., Baschieri L. Carcinoma della tiroide: risultati di uno studio su 185 pazienti. J. Endocrinol. Invest. 4(Suppl.): 207, 1981.
Ambrosino N., Bramanti M. Non invasive microwave monitoring of respiratory pattern. J. Med. Eng. Technol. 7: 224, 1983.
Konno K., Mead J. Measurement of the separate volume changes of rib cage and abdomen during breathing. J. Appl. Physiol. 22: 407, 1967.
Read D.J.C. A clinical method for assessing the ventilatory response to carbon dioxide. Aust. Ann. Med. 76: 20, 1967.
Milic-Emili J., Grunstein M.M. Drive and timing components of ventilation. Chest 70: 131, 1976.
Martino E., Sardano G., Vaudagna G., Bambini G., Breccia M., Motz E., Ciampi M., Baschieri L., Pinchera A. Serum myoglobin in primary hypothyroidism and- effect of L-thyroxine therapy. J.Nucl. Biol. Med. 23:1088, 1982.
Kasai K. Serum myoglobin level in altered thyroid states. J. Clin. Endocrinol. Metab. 48: 1, 1979.
DeGroot L.J., Larsen P.R., Refetoff S., Stahbury J.B. Thyroid and its diseases. Wiley Medical, New York, 1984.
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Ambrosino, N., Pacini, F., Paggiaro, P.L. et al. Impaired ventilatory drive in short-term primary hypothyroidism and its reversal by L-triiodothyronine. J Endocrinol Invest 8, 533–536 (1985). https://doi.org/10.1007/BF03348555
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DOI: https://doi.org/10.1007/BF03348555