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Effect of unilateral or bilateral thyroidectomy on TRH content of hypothalamus halves

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Abstract

The effect of uni-or bilateral thyroidectomy on the thyrotropin-releasing hormone (TRH) content of the mediobasal hypothalamus (MBH) of the two sides was studied in male rats. Both right- and left-side hemithyroidectomy resulted in a significantly increased TRH content in both halves of the MBH. In addition, the total TRH content rise of the MBH was higher after unilateral than after bilateral thyroidectomy. The mechanism of action of uni-or bilateral thyroidectomy on the hypothalamic TRH content is discussed.

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References

  1. Clark O.H., Lambert W.R., Cavalieri R.R., Rapoport B., Hammond M.E., Ingbar S.H. Compensatory thyroid hypertrophy after hemithyroidectomy in rats. Endocrinology 99:983, 1976.

    Google Scholar 

  2. Lewinski A., Ryzewska M., Pawlikowski M., Owczarczyk I. Effects of phentolamine on serum concentrations of TSH and thyroid hormones in hemithyroidectomized rats. Endokrinologie 78:219, 1981.

    CAS  PubMed  Google Scholar 

  3. Gerendai I., Rotsztejn W.H., Marchetti B., Kordon C., Scapagnini U. Unilateral ovariectomy-induced luteinizing hormone-releasing hormone content changes in the two halves of the mediobasal hypothalamus. Neurosci. Letters 9:333, 1978.

    Article  CAS  Google Scholar 

  4. Grouselle D., Faivre-Bauman A., Tixier-Vidal A. A radioimmunoassay forthyroliberin (TRH). Comparison with a TRH radioreceptor assay. Neurosci. Letters 7:7, 1978.

    Article  CAS  Google Scholar 

  5. Grouselle D., Tixier-Vidal A., Pradelles Ph. A new improvement of the sensitivity and specificity of radioimmunoassay forthyroliberin. Application to biological samples. Neuropeptides 3:29, 1982.

    Article  CAS  PubMed  Google Scholar 

  6. Mizunuma H., DePalatis L.R., McCann S.M. Effect of unilateral orchidectomy on plasma FSH concentration: evidence for a direct neural connection between testes and CNS. Neuroendocrinology 37:291, 1983.

    Article  CAS  PubMed  Google Scholar 

  7. Bauer K. Regulation of degradation of thyrotropin-releasing hormone by thyroid hormones. Nature 259:591, 1976.

    Article  CAS  PubMed  Google Scholar 

  8. Dupont A., Labrie F., Levasseur L., Dussault J.H., Serially A.V. Effects of thyroxine on the inactivation of thyrotropin-releasing hormone by rat and human plasma. Clin. Endocrinol. (Oxf.) 5:323, 1976.

    Article  CAS  Google Scholar 

  9. White N., Jeffcoate S.L., Griffiths E.C., Hooper K.C. Effect of thyroid status on the thyrotropin-releasing hormone-degrading activity of rat serum. J.Endocrinol. 71:13, 1976.

    Article  CAS  PubMed  Google Scholar 

  10. Jackson I. M.D., Papapetrou P.D., Reichlin S. Metabolic clearance of thyrotropin-releasing hormone in the rat in hypothyroid and hyperthyroid states: Comparison with serum degradation in vitro. Endocrinology 104:1292, 1979.

    Article  CAS  PubMed  Google Scholar 

  11. Emerson C.H., Vogel W., Currie B.L Concentrations of thyrotropin-releasing hormone (TRH) and deamido-TRH, and TRH deamidase activity in brain. Endocrinology 107:443, 1980.

    Article  CAS  PubMed  Google Scholar 

  12. Aratan-Spire S., Moilanen K., Czemichow P. Postnatal development pattern of thyrotropin releasing hormone-degrading activity in rat plasma, hypothalamus and liver: role of triiodothyronine. J. Endocrinol. 97:409, 1983.

    Article  CAS  PubMed  Google Scholar 

  13. Shinha D., Meites J. Effects of thyroidectomy and thyroxine on hypothalamic concentration of “thyrotropin releasing factor” and pituitary content of thyrotropin in rats. Neuroendocrinology 1:4, 1965/66.

    Article  Google Scholar 

  14. Montoya E., Seibel M.J., Wilber J.F. Thyrotropin releasing hormone secretory physiology: studies by radioimmunoassay and affinity chromatography. Endocrinology 96:1413, 1975.

    Article  CAS  PubMed  Google Scholar 

  15. Ching M. C.-H. Utiger R.D. Hypothalamic portal blood immunoreactive TRH in the rat: lack of effect of hypothyroidism and thyroid hormone treatment. J. Endocrinol. Invest. 6:347, 1983.

    CAS  PubMed  Google Scholar 

  16. Kardon F., Marcus R.J., Winokur A., Utiger R.D. Thyrotropin-releasing hormone content of rat brain and hypothalamus: results of endocrine and pharmacologic treatment. Endocrinology 100:1604, 1977.

    Article  CAS  PubMed  Google Scholar 

  17. Utsumi M., Makimura H., Tateiwa M., Sakoda M., Baba S. Effects of thyroxine and cold exposure on hypothalamic TRH levels in rats with various pituitary-thyroid states. Endocrinol. Jpn. 24:537, 1977.

    Article  CAS  PubMed  Google Scholar 

  18. Roti E., Christianson D., Harris A.R.C., Braverman L.E., Vagenakis A.G. “Short” loop feedback regulation of hypothalamic and brain thyrotropin-releasing hormone content In the rat and dwarf mouse. Endocrinology 103:1662, 1978.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. 2nd Department of Anatomy, Semmelweis University Medical School, 1094, Budapest, Tüzolto 58, Hungary

    I. Gerendai & A. Nemeskéri

  2. Groupe de Neuroendocrinologie Cellulaire, Laboratoire de Physiologie Cellulaire, Paris, France

    A. Faivre-Bauman, D. Grouselle & A. Tixier-Vidal

Authors
  1. I. Gerendai
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  2. A. Nemeskéri
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  3. A. Faivre-Bauman
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  4. D. Grouselle
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  5. A. Tixier-Vidal
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Gerendai, I., Nemeskéri, A., Faivre-Bauman, A. et al. Effect of unilateral or bilateral thyroidectomy on TRH content of hypothalamus halves. J Endocrinol Invest 8, 321–323 (1985). https://doi.org/10.1007/BF03348505

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  • DOI: https://doi.org/10.1007/BF03348505

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