Skip to main content
SpringerLink
Log in

LRFD6ahas a dose-related stimulatory or inhibitory effect on the ovary in normal luteal phase women

  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

A dose response curve for LRFD6a-a potent LRF agonist-was established in normal midluteal phase women. At low doses (3-10μg) an acute stimulatory effect on gonadotropins and ovarian steroidogenesis of estradiol and progesterone was observed. Despite large increases in circulating gonadotropins following the highest dose (30/¿g LRFD6a), no acute changes in plasma steroids were noted. A sharp drop in progesterone was present after 3 days, with significant shortening of the cycle in 3 of 4 subjects in the group. While the stimulatory effect may be due to gonadotropin release and local action, the luteolytic effect observed is suggested to be a consequence of the direct inhibitory effect of the analog on ovarian function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Schally A.V., Commaru Schally A.M., Martin A.L Present status of the use of LHRH and its analogs in the diagnosis and therapy of infertility. In: Belling CG., Wentz A.C. (Eds.), The LH-releasing hormone. Masson Inc., New York, 1980, p. 1.

    Google Scholar 

  2. Humphrey R.P., Windsor B.C., Boinsley F.G., Edgren R.A. Antifertility effects of an analog of luteinizing hormone releasing hormone (LHRH) in rats. Contraception 19: 625, 1976.

    Article  Google Scholar 

  3. Lemay A., Labrie F., Ferland L., Raynaud J.P. Possible luteolytic effects of luteinizing hormone-releasing hormone in normal women. Fertil. Steril. 31: 29, 1976.

    Google Scholar 

  4. Casper R., Yen S. Induction of luteolysis in the human with a long-acting analog of luteinizing hormone-releasing factor. Science 205: 408, 1979.

    Article  CAS  PubMed  Google Scholar 

  5. Bex F.J., Corbin A. Mechanism of the postcoital contraceptive effect of luteinizing hormone-releasing hormone: ovarian luteinizing hormone receptor interactions. Endocrinology 105: 139, 1979.

    Article  CAS  PubMed  Google Scholar 

  6. Clayton R.N., Harwood J.P., Catt K.J. Gonadotropin-releasing hormone analogue binds to luteal cells and inhibits progesterone production. Nature 282: 90, 1979.

    Article  CAS  PubMed  Google Scholar 

  7. Ekholm C., Clark M.R., Magnusson C., Isaksson O., Le-Maire W.J. Ovulation induced by a gonadotropin releasing hormone analog in hypophysectomized rats involves prostaglandins. Endocrinology 110: 288, 1982.

    Article  CAS  PubMed  Google Scholar 

  8. Catt K.J., Harwood J.P., Clayton R.N., Davies T.F., Chan V., Katikineni M., Nozu K., Dufau M.L Regulation of peptide hormone receptors and gonadal steroidogenesis. Recent Prog. Horm. Res. 36: 557, 1980.

    CAS  PubMed  Google Scholar 

  9. Jaffe B.M., Behrman H.R. Methods of hormone radioimmunoassay. Academic Press Inc., New York, 1979.

    Google Scholar 

  10. Koyama T., Ohkura T., Kumasaka T., Saito M. Effect of postovulatory treatment with a luteinizing hormone-releasing hormone analog on the plasma level of progesterone in women. Fertil. Steril. 30: 549, 1978.

    CAS  PubMed  Google Scholar 

  11. Stone S.C., Dickey R.P., Kastin A.J., Schally A.V. LHRH and steroid levels in normal ovulatory women. Obstet. Gynecol. 48:146, 1976.

    CAS  PubMed  Google Scholar 

  12. Caldwell B.V., Rotchell Y.E., Pang C.Y., Anderson G.G., Kase N., Behrman H.R. Comparative study of high dose chorionic gonadotropin on the human and rat corpus luteum and effect of gonadotropin-releasing hormone on human luteal function. Am. J. Obstet. Gynecol. 126: 458, 1980.

    Google Scholar 

  13. Lemay A., Faure N., Labrie F. Sensitivity of pituitary and corpus luteum response to single intranasal administration of (D-Ser [TBU]6-des-Gly-NH210) luteinizing hormone-releasing hormone ethylamide (Buserelin) in normal women. Fertil. Steril. 37:193, 1982.

    CAS  PubMed  Google Scholar 

  14. Sheehan K.L., Casper R.F., Yen S. Induction of luteolysis by luteinizing hormone-releasing factor (LRF) agonist: sensitivity, reproducibility and reversibility. Fertil. Steril. 37: 209, 1982.

    CAS  PubMed  Google Scholar 

  15. Sheehan K.L., Casper R.F., Yen S. Luteal phase defects induced by an agonist of luteinizing hormone-releasing factor: a model for fertility control. Science 215:170, 1982.

    Article  CAS  PubMed  Google Scholar 

  16. Corbin A., Bex F.J. Luteinizing hormone releasing hormone agonists induce ovulation in hypophysectomized proestrous rats: direct ovarian effect. Life Sci. 29:185, 1981.

    Article  CAS  PubMed  Google Scholar 

  17. Casper R.F., Erikson G.F., Rebar R.W., Yen S. The effect of luteinizing hormone releasing factor and its agonist on cultured human granulosa cells. Fertil. Steril. 406: 37, 1982.

    Google Scholar 

  18. Tureck R.W., Mastroianni L., Strauss III J.F. Inhibition of human granulosa cell progesterone secretion by a gonadotropin-releasing-hormone agonist. J. Clin. Endocrinol. Metab. 54:1078, 1982.

    Article  CAS  PubMed  Google Scholar 

  19. Popkin R., Brambly T.A., Currie A., Shaw R.W., Baird D.T., Fraser H.M. Specific binding of luteinizing hormone releasing hormone to human luteal tissue. Biochem. Biophsy. Res. Commun. 114: 750, 1983.

    Article  CAS  Google Scholar 

  20. Meldrum D.R., Tsao Z., Monroe S.E., Braunstein G.D., Sladek J., Lu J.K.H., Vale W., Rivier J., Judd H.L., Chang R.J. Stimulation of LH fragments with reduced bioactivity following GnRH agonist administration in women. J. Clin. Endocrinol. Metab. 58: 755, 1984.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA

    E. R. Barnea, R. Maheux, B. V. Caldwell, J. DeFazio, A. H. DeCherney & F. Naftolin M.D., D. Phil.

Authors
  1. E. R. Barnea
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Maheux
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. V. Caldwell
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. DeFazio
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. H. DeCherney
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F. Naftolin M.D., D. Phil.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Barnea, E.R., Maheux, R., Caldwell, B.V. et al. LRFD6ahas a dose-related stimulatory or inhibitory effect on the ovary in normal luteal phase women. J Endocrinol Invest 8, 297–302 (1985). https://doi.org/10.1007/BF03348501

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03348501

Key-words

Search

Navigation