Abstract
Bromocriptine, because of its dopaminergic activity, could possibly inhibit TSH secretion. This hypothesis was tested in 7 normal male volunteers. Thyroid function was suppressed with the very potent thyromimetic analogue, 3′isopropyl-3, 5-diiodo-L-thyronine (DIIP). We wanted to observe, after stopping this treatment, whether the return of serum T3, T4, rT3 and TSH values was influenced by concomitant bromocriptine treatment (5 mg/day). For comparison, the DIIP study was also performed without bromocriptine treatment. In both cases, serum T4 and serum T3, which had decreased by, respectively, 34% ± 5% and 17% ± 5%, returned over the same time interval to their initial values. Serum TSH and TRH-mediated TSH secretion were also unaffected by the bromocriptine treatment. DIIP does not interfere in the serum determination of T3, T4 and rT3. During suppression with DIIP serum T3 fell less than serum T4 and returned more rapidly to its initial concentrations. It is concluded that dopaminergic inhibition by bromocriptine, at this dose, is insufficient to alter normal thyroid function. In addition, during suppression and shortly thereafter there is a tendency for the serum T3 levels to be maintained.
Similar content being viewed by others
References
Parkes D. Bromocriptine. N. Engl. J. Med. 301: 16, 1979.
Kebabian J., Calne D. Multiple receptors for dopamine. Nature 277: 93, 1979.
Morley J. Neuroendocrine control of thyrotropin secretion. Endocrine Rev. 2: 4, 1981.
Yap P.L., Mc Davidson N. M., Lidgard G.P., Fyffe J. A. Bromocriptine suppression of thyrotropin response to thyrotropin releasing hormone. Clin. Endocrinol. (Oxf.) 9: 179, 1978.
Jlikorkala O., Kivinen S., Ronnberg L., Viinikka L. Bromocriptine suppresses TSH response to TRH during human pregnancy. Clin. Endocrinol. (Oxf.) 13: 253, 1980.
Kobberling J., Darracgh A., del Pozo E. Chronic dopamine receptor stimulation using bromocriptine: failure to modify thyroid function. Clin. Endocrinol. (Oxf.) 11: 367, 1979.
Gharib H., Ryan R.J., Mayberry W.E., Hockert T. Radioimmunoassay for T3. Affinity and specificity of an tibody for T3. J. Clin. Endocrinol. Metab. 33: 509, 1971.
Patel J. C., Burger H.G., Hudson B. Radioimmunoassay of serum thyrotropin: sensitivity and specificity. J. Clin. Endocrinol. Metab. 33: 768, 1971.
Chopra I.J., Solomon D.H., Ho R.S. A radioimmunoassay of thyroxine. J. Clin. Endocrinol. Metab. 33: 865, 1971.
Chopra I.J., Solomon D.H., Beall G.N. Radioimmunoassay for measurement of triiodothyro nine in human serum. J. Clin. Invest. 50: 2033, 1971.
Kaiser C., Salomon-Montavon N., Merkelbach U., Burger A.G. 3′isopropyl-3, 5-diiodo-L-thyronine: a potent synthetic thyromimetic thyronine analogue. Studies of its kinetig and biological potency in man and rats, and its toxicology. J. Clin. Endocrinol. Metab. 57: 44, 1983.
Scanion M.F., Weetman A.P., Lewis M., Pourmand M., Rodriguez-Arnao D., Weightman D.R., Hall R. Dopaminergic modulation of circadian thyrotropin rhyt-mus and thyroid hormones levels in euthyroid subjects. J. Clin. Endocrinol. Metab. 56: 6, 1980.
Scanlon M.F., Weightman D.R., Shale D.J., Mora B., Heath M., Snow M.H., Lewis M., Hall R. Dopamine is a physiological regulator of thyrotropin secretion in normal man. Clin. Endocrinol. (Oxf.) 10: 7, 1979.
Scanlon M.F., Weightman D.R., Mora B., Shale D.J., Heath M., Snow M.H., Hall R. Evidence for dopaminergic control of thyrotropin secretion in man. Lancet 2: 421, 1977.
Sowers J., Catania R., Hershman J. Evidence for dopaminergic control of circadian variations in thyrotropin secretion. J. Clin. Endocrinol. Metab. 54: 4, 1982.
Kaptein E.M., Spencer C., Kamiel M., Nicoloff J. T. Prolonged dopamine administration and thyroid hormone economy in normal and critically ill subjects. J. Clin. Endocrinol. Metab. 51: 2, 1980.
Kaptein E.M., Kletzky O.A., Spencer C., Nicoloff J. T. Effect of prolonged dopamine infusion on anterior pituitary function in normal males. J. Clin. Endocrinol. Metab. 57: 2, 1980.
Kaptein E.M., Robinson W.J., Grieb D.A., Nicoloff J. T. Peripheral serum thyroxine, triiodothyronine and reverse triiodothyronine kinetics in the triiodothyronine low states of acute nonthyroidal illness. J. Clin. Invest. 69: 526, 1982.
Werner S.C., Ingbar S.H. The Thyroid, ed. 4. Harper and Row, Hagerstown Maryland, New-York, San Francisco, London, 1978, p. 219.
Vagenakis A.G., Koutras D.A., Burger A., Malamas B., Ingbar S.H., Braverman L.E. Studies of serum triiodothyronine, thyroxine and thyrotropine concentrations in endemic goiter in Greece. J. Clin. Endocrinol. Metab. 37: 485, 1973.
Abuid J., Larsen P.R. Triiodothyronine and thyroxine in hyperthyroidism. J. Clin. Invest. 54: 201, 1974.
Lum S.M.C., Nicoloff J. T., Spencer C., Kaptein E.M. Peripheral tissue mechanism for maintenance of serum triiodothyronine values in a thyroxine-deficient state in man. J. Clin. Invest. 73: 570, 1984.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Salomon-Montavon, N.A., Burger, A.G. Recovery of serum TSH and thyroid hormones after 3′isopropyl-3,5-diiodo-L-thyronine (DIIP) treatment: absence of inhibiting effect of bromocriptine on TSH secretion and evidence for autoregulation of serum T3 levels. J Endocrinol Invest 7, 501–505 (1984). https://doi.org/10.1007/BF03348457
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03348457