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The endocrine pattern of late onset adrenal hyperplasia (21-hydroxylase deficiency)

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Abstract

We describe 5 adult women with severe hirsutism due to late onset 21-hydroxylase deficiency. Diagnosis was performed on the finding of high serum 17-hydroxyprogesterone (170HP) levels with a marked hyperresponse to an ACTH test. The endocrine study showed in most patients a gonadotropin behaviorsimilarto that observed inclassical polycystic ovary (PCO) syndrome. Prolactin levels were slightly increased in basal conditions and presented an exaggerated response to TRH stimulation.

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Authors and Affiliations

  1. Istituto di Endocrinologia e Fisiopatologia della Riproduzione, Cattedra di Endocrinologia, Università di Palermo, Via delle Croci 47, 90139, Palermo, Italy

    E. Carmina, A. M. Gagliano, F. Rosato, M. Maggiore & A. Jannì

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  1. E. Carmina
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  2. A. M. Gagliano
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  3. F. Rosato
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  4. M. Maggiore
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  5. A. Jannì
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Carmina, E., Gagliano, A.M., Rosato, F. et al. The endocrine pattern of late onset adrenal hyperplasia (21-hydroxylase deficiency). J Endocrinol Invest 7, 89–92 (1984). https://doi.org/10.1007/BF03348395

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  • DOI: https://doi.org/10.1007/BF03348395

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