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Response of Paget’s disease to human calcitonin in patients resistant to porcine calcitonin

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Abstract

Eleven patients with Paget’s disease of bone, treated intermittently for 2–4 years with porcine calcitonin (pCT) and clinically resistant to pCT [no modifications of serum alkaline phosphatase (ALP) and urinary hydroxyproline (uHOP) during pCT administration] were treated with 0.5–0.25 mg/day of human calcitonin (hCT) for 3–6 months. Nine of our patients showed biochemical improvement during the first 2 months of treatment, with reduction in ALP and uHOP. In one patient with slightly increased ALP and uHOP, and in another one during the second treatment course, hCT treatment did not modify the biochemical indices of bone disease. However all patients, including those with biochemical resistance, experienced a remarkable diminution of bone pain, which had not been observed during previous pCT treatment courses. Therefore, hCT appears to be indicated for therapeutic use in patients who are resistant to foreign calcitonins.

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References

  1. Bijvoet O.L.M., Jansen A.P. Thyrocalcitonin in Paget’s disease. Lancet 2: 471, 1967.

    Article  Google Scholar 

  2. Woodhouse N.J.Y., Reiner M., Bordier Ph., Kalu D.N., Fisher R., Foster G.V., Joplin G.F., MacIntyre I. Human calcitonin in the treatment of Paget’s bone disease. Lancet 1: 1139, 1971.

    Article  PubMed  CAS  Google Scholar 

  3. Hamilton R.P. Effects of synthetic salmon calcitonin in patients with Paget’s disease of bone. Am. J. Med. 56: 315, 1974.

    Article  PubMed  Google Scholar 

  4. Mandelier T.H., Fuss M., Brauman J., Orloff S., Bersan A., Corvillain J. Traitment de la maladie de Paget par la calcitonine de saumon. Rev. Rhum. Mal. Osteaartie. 44: 59, 1977.

    Google Scholar 

  5. Evans I.M.A., Doyle F.H., Banks L., Pennock J., Joplin G.F., MacIntyre I. Paget’s disease: results of long-term treatment with synthetic human calcitonin. In: MacIntyre I., Szelke M. (Eds.), Molecular Endocrinology. Holland Biomedical Press, Amsterdam, 1977, p. 235.

    Google Scholar 

  6. MacIntyre I., Evans I.M.A., Hobitz H.H.G., Joplin G.F., Stevenson J.C. Chemistry, physiology and therapeutical applications of calcitonin. Arthritis Rheum. 23: 1139, 1980.

    Article  PubMed  CAS  Google Scholar 

  7. Doyle F.H., Banks L.M., Pennock J.M. Radiological observations on bone resorption in Paget’s disease. Arthritis Rheum. 23: 1205, 1980.

    Article  PubMed  CAS  Google Scholar 

  8. DeRose J., Singer F.R., Avramides A., Flores A., Dziadiw R., Baker R.K., Wallach S. Response of Paget’s disease to porcine and salmon calcitonins. Am. J. Med. 56: 858, 1974.

    Article  PubMed  CAS  Google Scholar 

  9. Singer F.R., Aldred J.P., Neer R.M., Krane S.M., Potts J.T. Jr., Bloch K.J. An evaluation of antibodies and clinical resistance to salmon calcitonin. J. Clin. Invest. 51: 2331, 1972.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  10. Haddad J.G. Jr., Caldwell J.G. Calcitonin resistance: clinical and immunological studies in subjects with Paget’s disease of bone treated with porcine and salmon calcitonins. J. Clin. Invest. 51: 3133, 1972.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Dubè W.J., Goldsmith R.S., Arnaud S.B., Arnaud C.D. Development of antibodies to porcine calcitonin during treatment of Paget’s disease of bone. Mayo Clin. Proc. 48: 43, 1973.

    PubMed  Google Scholar 

  12. Rojanasathit S., Rosenberg E., Haddad J.G. Jr. Paget’s bone disease: response to human calcitonin in patients resistant to salmon calcitonin. Lancet 2: 1412, 1974.

    Article  PubMed  CAS  Google Scholar 

  13. Dubè W.J., Goldsmith R.S., Arnaud S.B., Arnaud C.D. Hyperparathyroidism secondary to long term therapy of Paget’s disease of bone with calcitonin. Excerpta Medica Int. Congress Series No. 243, Amsterdam, 1972, p. 113.

    Google Scholar 

  14. Singer F.R., Rude R.K., Mills B.G. Studies of the treatment and etiology of Paget’s disease of bone. In: MacIntyre I. (Ed.), Human calcitonin and Paget’s disease. Hans Huber, Bern, 1977, p. 93.

    Google Scholar 

  15. Martin J.J. Treatment of Paget’s disease with calcitonins. Aust. NZ J. Med. 9: 36, 1979.

    Article  CAS  Google Scholar 

  16. Adami S., Ferrari M., Galvanini G., Lazzaretto R., Marini G., Facchinetti R., Lo Cascio V. Cyclic AMP response to intravenous injection of human calcitonin in Paget’s disease of bone. In: Silbermann M., Slavkin H.C. (Eds.), Current advances in skeletogenesis. Excerpta Medica, Amsterdam, 1982, p. 504.

    Google Scholar 

  17. Barbarino A., Pinna G., Balducci L., Pasargikilian E. Osservazioni metodologiche sulla determinazione della idrossiprolina urinaria. Gazzetta Int. Med. 48: 65, 1968.

    Google Scholar 

  18. Lo Cascio V., Cominacini L., Corgnati A., Adami S., Galvanini G., Bianchi I., Scuro L.A. Primi rilievi sull’utilità del dosaggio radioimmunologico del paratormone nella diagnosi di iperparatirodismo primitivo. Minerva Endocrinol. 2: 19, 1977.

    Google Scholar 

  19. Dietrich F.M. Immunological studies with synthetic human calcitonin. In: MacIntyre I. (Ed.), Human calcitonin and Paget’s disease. Hans Huber, Bern, 1977, p. 179.

    Google Scholar 

  20. Dietrich F.M., Fischer J.A., Bijvoet O.L.M. Formation of antibodies to synthetic human calcitonin during treatment of Paget’s disease. Acta Endocrinol. (Kbh.) 92: 468, 1979.

    CAS  Google Scholar 

  21. Singer F.R., Fredericks R.S., Minfin C. Salmon calcitonin therapy for Paget’s disease of bone. Arthritis Rheum. 23: 1148, 1980.

    Article  PubMed  CAS  Google Scholar 

  22. Woodhouse N.J.Y. Mohamedally S.M., Saed-Nejad F., Martin T.J. Development and significance of antibodies to salmon calcitonin in patients with Paget’s disease on long-term treatment. Br. Med. J. 2: 927, 1977.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  23. Hosking D.J. Clinical significance of calcitonin antibodies. In: Pecile A. (Ed.), Calcitonin 1980. Excerpta Medica, Amsterdam, 1981, p. 365.

    Google Scholar 

  24. Raisz L.G. Werner J.A., Trummel C.L., Feinblatt J.D., Au W.Y.W. Induction, inhibition and escape as phenomena of bone resorption. In: Talmage R.V., Munson P.L. (Eds.), Calcium, parathyroid hormone and calcitonin. Proocedings of fourth Parathyroid Conference. Excerpta Medica, Amsterdam, 1972, p. 446.

    Google Scholar 

  25. Burckardt P.M., Ducommun J., Hessler C. Treatment of Paget’s disease with human calcitonin. Hans Huber, Bern, 1977, p. 155.

    Google Scholar 

  26. Greenberg P.B., Doyle F.H., Fisher M.T., Hillyard C.J., Joplin G.F., Pennock J., MacIntyre I. Treatment of Paget’s disease of bone with synthetic human calcitonin. Am. J. Med. 56: 867, 1974.

    Article  PubMed  CAS  Google Scholar 

  27. Commandre F., Michelangeli J., Lartigues G., Viani J.L., Georges D. Ostéoporose et thyrocalcitonine. Etude sur 61 observations. Vie Médicale 34: 4215, 1974.

    Google Scholar 

  28. Pecile A., Feni S., Braga G.P., Olgiati V.R. Effect of intracerebroventricular calcitonin in the consciuos rabbit. Experientia 31: 332, 1975.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Istituto di Semeiotica Medica and Clinica Medica, Università di Verona, Policlinico Borgo Roma, 37134, Verona, Italy

    V. Lo Cascio & S. Adami

  2. Ciba-Geigy S.p.A., Ricerche Cliniche, Padova, Italy

    G. Galvanini, R. Lazzaretto, M. Ferrari, D. Tartarotti & L. A. Scuro

Authors
  1. V. Lo Cascio
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  2. S. Adami
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  3. G. Galvanini
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  4. R. Lazzaretto
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  5. M. Ferrari
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  6. D. Tartarotti
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  7. L. A. Scuro
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Lo Cascio, V., Adami, S., Galvanini, G. et al. Response of Paget’s disease to human calcitonin in patients resistant to porcine calcitonin. J Endocrinol Invest 7, 85–88 (1984). https://doi.org/10.1007/BF03348394

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  • DOI: https://doi.org/10.1007/BF03348394

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