Abstract
To study the effect of caffein on growth hormone secretion a culture system of dispersed rat anterior pituitary cells was employed. The cells were incubated overnight in medium 199 containing 10−5 to 10−1 M caffein. The medium was then collected and assayed for rat growth hormone content. A dose dependent stimulatory effect of caffein on growth hormone secretion into the culture medium was observed. It is concluded that caffein, like other xantines phosphor-diesterase inhibitors stimulates growth hormone secretion by a direct effect on pituitary cells.
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Supported by a grant from Nordisk Insulinlaboratorium, Denmark.
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Hochberg, Z., Hertz, P. & Benderly, A. Caffein stimulates growth hormone secretion by cultured rat pituitary cells. J Endocrinol Invest 7, 59–60 (1984). https://doi.org/10.1007/BF03348378
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DOI: https://doi.org/10.1007/BF03348378