Abstract
The volume of sella turcica (VST) was estimated from x-ray films in i) 883 control subjects (507 men and 376 women), ii) 135 adult patients with peripheral endocrine gland insufficiences (71 of the thyroid, 15 of the adrenals and 49 of the gonads) and iii) 41 adult patients with idiopathic gonadotropin deficiency. The mean VST value of men (1356 ± 22 mm3) was significantly lower (p< 0.05) than that of women (1428 ± 25 mm3). This difference resulted from a progressive increase of VST in women after the age of 45 (r = 0.254, p< 0.001); the mean VST value of women aged < 45 years (1301 ± 33 mm3) been similar to that of men (p> 0.05). VST was significantly (p< 0.001) increased in peripheral endocrine insufficiences, this increase varying approximately between + 30% and + 55% of the mean volume of normals according to the endocrinopathy. Definitely abnormal sella turcica (VST larger than + 2SD) were observed in a percentage smaller than 27% of the cases in all groups. Furthermore, the increase in VST was significantly related to the severity of the disease in primary hypothyroidism (p<0.001) and the duration of the abnormal condition in Addison’s disease and primary gonadal failure (p< 0.001). Finally, VST was found within normal limits in patients with idiopathic gonadotropin deficiency. It is concluded that natural (menopause) or pathological peripheral endocrine insufficiency leads to VST enlargement which exceeds the upper normal limits in less than 27% of the cases.
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Moore G.E., Brackney E.L., Bock F.G. Production of pituitary tumors in mice by chronic administration of a thiouracil derivative. Proc. Soc. Exp. Biol. Med. 82: 643, 1953.
Fürth J., Dent N.N., Burnett W.T., Gadsen E.L. The mechanism of induction and the characteristics of pituitary tumors induced by thyroidectomy. J. Clin. Endocrinol. Metab. 15: 81, 1955.
Caughey J.E. Hypogonadism and pituitary tumors. N. Z. Med. J. 60: 482, 1961.
Lawrence A.M., Wilber J.F., Hagen Th. C. The pituitary and primary hypothyroidism. Arch. Intern. Med. 132: 327, 1973.
Russfield A.B. Histology of the human hypophysis in thyroid disease: Hypothyroidism, hyperthyroidism, and cancer. J. Clin. Endocrinol. Metab. 15: 1393, 1955.
Vagenakis A.G., Dole K., Braverman L.E. Pituitary enlargement, pituitary failure and primary hypothyroidism. Ann. Intern. Med. 85: 195, 1976.
Gordon S.J., Moses A.M. Multiple endocrine organ refractoriness to trophic stimulation. A patient with an enlarged sella turcica and increased FSH secretion. Ann. Intern. Med. 63: 313, 1965.
Samaan N.G., Osborne B.M., Mackay B., Leavens M.E., Duello T.M., Halmi N.S. Endocrine and, morphologic studies of pituitary adenomas secondary to primary hypothyroidism. J. Clin. Endocrinol. Metab. 45: 903, 1977.
Leiba S., Landau B., Ber A. Target gland insufficiency and pituitary tumors. Acta Endocrinol. (Kbh.) 60: 112, 1969.
Patel Y.C., Kilpatric J.A. Pituitary enlargement with long-standing myxedema. N. Z. Med. J. 70: 21, 1969.
Jackson I.M.D., Hall R. Pituitary enlargement resulting from primary thyroid disease. Proc. R. Soc. Med. 63: 578, 1970.
Balsam A., Oppenheimer J.H. Pituitary tumor with primary hypothyroidism. N. Y. State J. Med. 75: 1737, 1975.
Kelly L.W. Ovarian dwarfism with pituitary tumor. J. Clin. Endocrinol. Metab. 23: 50, 1963.
Dluhy R.G., Moore T.J., Williams G.H. Sella turcica enlargement and primary adrenal insufficiency. Ann. Intern. Med. 89: 513, 1978.
Himsworth R.C., Levis J.G., Rees L.H. A possible ACTH secreting tumour of the pituitary developing in a conventionally treated case of Addison’s disease. Clin. Endocrinol. (Oxf.) 9: 131, 1978.
Jara-Albaran A., Bayort J., Caballero A., Portillo J., Laborela L., Sampedro M., Cure C., Palacios Mateos J.M. Probable pituitary adenoma with adrenocorticotropin hypersecretion (corticotropinoma) secondary to Addison’s disease. J. Clin. Endocrinol. Metab. 49: 236, 1979.
Aanderud S., Bassoe H.H. A pituitary tumor with possible ACTH and TSH hypersecretion in a patient with Addison’s disease and primary hypothyroidism. Acta Endocrinol. (Kbh.) 95: 181, 1980.
Yamada T.Y., Tsukui T., Ikejiri K., Yukimura Y., Kotani M. Volume of sella turcica in normal subjects and in patients with primary hypothyroidism and hyperthyroidism. J. Clin. Endocrinol. Metab. 42: 817, 1976.
Bigos S.T., Ridgway E.C., Kourides I.A., Maloof F. Spectrum of pituitary alterations with mild and severe thyroid impairment. J. Clin. Endocrinol. Metab. 46: 317, 1978.
Ntailianas A.C. Measurement of surface area and volume of the sella turcica. Thesis. Athens, 1976.
Fisher R.A. Statistical methods for research workers. Oliver and Boyd, Edinburgh, 1970.
Snedecor G.W., Cochran W.G. Statistical methods. The Iowa State University Press, Ames, 1971.
Di Chiro G., Nelson K. The volume of the sella turcica. Am. J. Roentgen. 87: 988, 1962.
Boukhris R., Sellami M., Guedri H., Ben Cheihk M., Ben Khalifa F., Ben Ayed H. Variations du volume de la selle turcique dans l’hypothyroidïe et l’hypopituitarisme. Nouv. Presse Med. 7: 210, 1978.
Hallberg M.C., Wieland R.G., Zorn E.M., Furst B.H., Wieland J.M. Impaired Leydig cell reserve and altered serum androgen binding in the aging male. Fertil. Steril. 27: 812, 1976.
Feek C.M., Ratcliffe J.G., Seth J., Gray C.E., Toft A.D., Irvine W.J. Patterns of plasma Cortisol and ACTH concentrations in patients with Addison’s disease tretated with conventional corticosteroid replacement. Clin. Endocrinol. (Oxf.) 14: 451, 1981.
Reitano J.F., Caminos-Torres L., Snyder P.J. Serum LH and FSH responses to repetitive administration of gonadotropin releasing hormone in patients with idiopathic hypogonadotropic hypogonadism. J. Clin. Endocrinol. Metab. 41: 1085, 1975.
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Preliminary results were presented at the 2nd Balkan Congress of Endocrinology, Belgrade, September 23–26, 1981.
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Singhellakis, P.N., Ntailianas, A.C., Alevizaki, C.C. et al. Volume of sella turcica in normals and patients with peripheral endocrinopathies or idiopathic gonadotropin deficiency. J Endocrinol Invest 6, 421–426 (1983). https://doi.org/10.1007/BF03348340
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DOI: https://doi.org/10.1007/BF03348340