Serum copper level and ceruloplasmin activity were measured in 104 middle class Iranian women from 17 to 49 years of age, using combined oral contraceptives from 3 to 108 months, and results were compared with those obtained from 24 normal individuals (21–45 years of age) from the same social class. Significant increases were observed in 100% of test subjects in serum copper level and ceruloplasmin activity (p < 0.005), which tend to decline following 48 months of intake, when liver probably adapts itself, and ceruloplasmin synthesis is not aggravated significantly any more. The variations observed in this study were higher than those obtained in Nigerian women and were comparable with those found in women from other countries.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Price includes VAT (USA)
Tax calculation will be finalised during checkout.
O’Leary J.A., Spellacy W.N. Serum copper alteration after ingestion of an oral contraceptive. Science 162: 682, 1968.
O’Leary J.A., Spellacy W.N. Zinc and copper levels in pregnant women and those taking oral contraceptives. Am. J. Obst. Gynecol. 103: 131, 1969.
Mendenhall H.W. Effect of oral contraceptives on serum protein concentrations. Am. J. Obst. Gynecol. 106: 718, 1970.
Horwitt M.K., Harvey C.O., Dohn C.H. Relationship between levels of blood lipids, vitamins C, A and E, serum copper compounds and urinary excretion of tryptophan metabolites in women taking oral contraceptive therapy. Am. J. Clin. Nutr. 28: 403, 1975.
Carruthers M.E., Hobbs C.B., Warren R.L. Raised serum copper and ceruloplasmin levels in subjects taking oral contraceptives. J.Clin. Pathol. 19: 498, 1966.
Halsted J.A., Mackley B.M., Smith Jr. J.C. Plasma zinc and copper in pregnancy and after oral contraceptives. Lancet 2: 278, 1968.
Derrick Tovey L.A., Lathe G.H. Ceruloplasmin and.green plasma in women taking oral contraceptives, in pregnant women, and in patients with rheumatoid arthritis. Lancet 2: 596, 1968.
Austin J., Staniford M. Oral contraceptives and copper metabolism. Nature 225: 81, 1969.
Daunter B., Elstein M. Serum levels of copper, ceruloplasmin and ceruloplasmin oxidase activity in women using copper containing intrauterine devices and in women taking combined oral contraceptives. J. Obst. Gynaecol. Br. Commonw. 80: 644, 1973.
Hefnawi F., Kandil O., Askalani H., Zaki K., Nasr F., Musa M. Copper levels in women using intrauterine devices or oral contraceptives. Fertil. Steril. 25: 556, 1974.
Olatunbosun D.A., Adeniyi F.A., Adadevoh B.K. The effect of oral contraceptives on serum copper levels in Nigerian women. J. Obst. Gynaecol. Br. Commonw. 80: 937, 1973.
Tietz W.B. Fundamentals of clinical chemistry. W.B. Saunders, Philadelphia, 1970, p. 663.
Schosinsky K.H., Lehmann H.P., Beeler M.F. Measurement of ceruloplasmin from its oxidase activity in serum by use of O-dianisidine dihydrochloride. Clin. Chem. 20: 1556, 1974.
Kamyab S., Baghdiantz A., Motamedi H. Variations in serum protein fractions following a continuous long term intake of Eugynon and Lyndiol in Iranian women. Steroid Biochemistry 9: 811, 1978.
About this article
Cite this article
Kamyab, S., Baghdiantz, A. & Jenati, S. Variations in serum copper and ceruloplasmin activity following a long term intake of combined oral contraceptives in Iranian women. J Endocrinol Invest 3, 173–175 (1980). https://doi.org/10.1007/BF03348246
- combined oral contraceptives