Skip to main content
Log in

Improved sperm counts in mink males (Mustela vison) treated with clomiphene citrate

  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

A group of 12 sterile, azoospermic mink males were treated with clomiphene citrate (10 mg/kg/day) for 10 days during the mating season; 50% of the males showed improved sperm counts already after 2 days of treatment and the maximum effect was seen 4–6 days after the start of the treatment. The other half of the group did not respond to the treatment and their sperm counts remained near zero during the whole experiment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Greenblatt R.B., Barfield W.E., Jungck E.C., Roy A.W. Induction of ovulation with MRL-41. JAMA 178: 101, 1961.

    Article  PubMed  CAS  Google Scholar 

  2. Hammond M.G. Monitoring techniques for improved pregnancy rates during clomiphene ovulation induction. Fertil. Steril. 42: 499, 1984.

    PubMed  CAS  Google Scholar 

  3. Thompson R.J., Mellinger R.C. The effect of clomiphene citrate in patients with pituitary-gonadal disorders. Am. J. Obstet. Gynecol. 92: 412, 1965.

    CAS  Google Scholar 

  4. Check J.H., Rakoff A.E. Improved fertility in oligospermic males treated with clomiphene citrate. Fertil. Steril. 28: 746, 1977.

    PubMed  CAS  Google Scholar 

  5. Check J.H. Improved semen quality in subfertile males with varicocele associated oligospermia following treatment with clomiphene citrate. Fertil. Steril. 33: 423, 1980.

    PubMed  CAS  Google Scholar 

  6. Tung K.S.K., Ellis L., Teuscher C., Meng A., Blaustein J.C., Kohno S., Howell R. The black mink (Mustela vison). A natural model of immunologie male infertility. J. Exp. Med. 154: 1061, 1981.

    Article  Google Scholar 

  7. Blasco L. Clinical tests of sperm fertilizing ability. Fertil. Steril. 41: 177, 1984.

    PubMed  CAS  Google Scholar 

  8. Ben-Baruch G., Schreiber G., Sokolovsky M. Cooperative pattern in the interaction of the antiestrogen drug clomiphene with the muscarinic receptors. Mol. Pharmacol. 21: 287, 1982.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lukola, A., Sundqvist, C. Improved sperm counts in mink males (Mustela vison) treated with clomiphene citrate. J Endocrinol Invest 9, 243–244 (1986). https://doi.org/10.1007/BF03348109

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03348109

Key-words

Navigation