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Histamine receptors and bioeffects on clonal parathyroid endothelial cells

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Abstract

Using a clonal line of bovine parathyroid endothelial cells (BPE-1) we defined the presence on these cells of a histamine H2 receptor and characterized its pharmacological properties. Interaction of histamine with its receptor induced an increase of cAMP accumulation in a dose- and time-dependent fashion. This effect appears unique for parathyroid endothelial cells, in fact, clonal parathyroid epithelial cells did not exhibit a similar response. No effect of histamine was observed on BPE-1 cell proliferation.

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Authors and Affiliations

  1. Unità di Endocrinologia, Dipartimento di Fisiopatologia, Università di Firenze, Viale Pieraccini 6, 50139, Firenze, Italy

    U. Frediani, S. Benvenuti, L. Masi &  M. L. Brandi

  2. Clinica Medica, University of Firenze, Firenze, Italy

    A. L. Tanini

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  1. U. Frediani
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  2. S. Benvenuti
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  3. L. Masi
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  4. A. L. Tanini
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  5. M. L. Brandi
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Frediani, U., Benvenuti, S., Masi, L. et al. Histamine receptors and bioeffects on clonal parathyroid endothelial cells. J Endocrinol Invest 19, 298–303 (1996). https://doi.org/10.1007/BF03347866

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