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Autoimmune thyroid disease and pregnancy

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References

  1. Volpé R. A perspective on human autoimmune thyroid disease: is there an abnormality of the target cell which predisposes to the disorder? Autoimmunity 13: 3, 1992.

    Article  PubMed  Google Scholar 

  2. Tomer Y., Davies T.F. Infections and autoimmune endocrine disease. Baillieres Clin. Endocrinol. Metab. 9: 47, 1995.

    Article  PubMed  CAS  Google Scholar 

  3. Anir S.M., Sullivan R.C., Ingbar S.H. In vitro responses to crude and purified hCG in human thyroid membranes.. J. Clin. Endocrinol. Metab. 51: 51, 1980.

    Article  Google Scholar 

  4. Davies T., Platzer M. hCG-induced TSH receptor activation and growth acceleration in FRTL-5 thyroid cells. Endocrinology 118: 2149, 1986.

    Article  PubMed  CAS  Google Scholar 

  5. Glinoer D., Nayer P., Bourdoux P., Lemone M., Robyn C., Steirteghem A., Kinthaert J., Lejeune B. Regulation of maternal thyroid during pregnancy. J. Clin. Endocrinol. Metab. 71: 276, 1990.

    Article  PubMed  CAS  Google Scholar 

  6. Amino N., Nishi K., Nakatani K., Mizuta H., Ichihara K., Tanizawa O., Miyai K. Effect of albumin concentration on the assay of serum free thyroxine by equilibrium radioimmunoassay with labeled thyroxine analog (Amerlex Free T4). Clin. Chem. 29: 321, 1983.

    PubMed  CAS  Google Scholar 

  7. Kimura M., Amino N., Tamaki H., Ito E., Mitsuda N., Miyai K., Tanizawa O. Gestational thyrotoxicosis and hyperemesis gravidarum: possible role of hCG with higher stimulating activity. Clin. Endocrinol. 38: 345, 1993.

    Article  CAS  Google Scholar 

  8. Tsuruta E., Tada H., Tamaki H., Kashiwai T., Asahi K., Takeoka K., Mitsuda N., Amino N. Pathogenic role of asialo-hCG in gestational thyrotoxicosis. J. Clin. Endocrinol. Metab. 80: 350, 1995.

    PubMed  CAS  Google Scholar 

  9. Hoermann R., Keutmann H., Amir S. Carbohydrate modifications transform human chorionic gonadotropin into a potent stimulator of adenosine 3′, 5′-monophosphate and growth responses in FRTL-5 thyroid cells. Endocrinology 128: 1129, 1991.

    Article  PubMed  CAS  Google Scholar 

  10. Parkey A., Jackson I., Goodwin T., Pang X., Hein M., Hershman J. Increased in vitro thyrotropic activity of partially sialated human chorionic gonadotropin extracted from hydatidiform moles of patients with hyperthyroidism. J Clin Endocrinol Metab. 76: 70, 1993.

    Google Scholar 

  11. Yoshimura M., Hershman J., Pang X., Berg L., Pekary A. Activation of the thyrotropin (TSH) receptor by human chorionic gonadotropin and lutenizing hormones in Chinese hamster ovary cells expressing functional human TSH receptors. J. Clin. Endocrinol. Metab. 77: 1009, 1993.

    PubMed  CAS  Google Scholar 

  12. Yoshimura M., Pekary A., Pang X., Berg L., Cole L., Kardana A., Hershman J. Effect of peptide nicking in the human chorionic gonadotropin ß-subunit on stimulation of recombinant human thyroid-stimulating hormone receptors. Eur. J. Endocrinol. 130: 92, 1994.

    Article  PubMed  CAS  Google Scholar 

  13. Momotani N., Ito K., Hamada N., Ban Y., Nishikawa Y., Mimura T. Maternal hyperthyroidism and congenital malformations in the offspring. Clin. Endocrinol. (Oxf.) 20: 695, 1984.

    Article  CAS  Google Scholar 

  14. Cooper D. Antithyroid drugs. N. Engl. J. Med. 311: 1353, 1984.

    Article  PubMed  CAS  Google Scholar 

  15. Momotani N., Noh J., Oyanaga H., Ishikawa N., Ito K. Antithyroid drug therapy for Graves’ disease during pregnancy. N. Engl. J. Med. 315: 24, 1986.

    Article  PubMed  CAS  Google Scholar 

  16. Amino N., Tanizawa O., Mori H., Iwatani Y., Tamada T., Kurachi K., Kumahara Y., Miyai K. Aggravation of thyrotoxicosis in early pregnancy and after delivery in Graves’ disease. J. Clin. Endocrinol. Metab. 55: 108, 1982.

    Article  PubMed  CAS  Google Scholar 

  17. Tamaki H., Itoh E., Kaneda T., Asahi K., Mitsuda N., Tanizawa O., Amino N. Crucial role of serum human chorionic gonadotropin for the aggravation of thyrotoxicosis in early pregnancy in Graves’ disease. Thyroid 3: 189, 1993.

    Article  PubMed  CAS  Google Scholar 

  18. Amino N., Iwatani Y., Tamaki H. Postpartum autoimmune thyroid syndromes. In: Walfish P.G., Wall J.R., Volpé R. (Ed.), Autoimmunity and the thyroid. Academic Press Inc., Orlando, 1985, p. 289.

    Chapter  Google Scholar 

  19. Bohnet H., Fieldlerk, Leidenberger F. Subclinical hypothyroidism and infertility. Lancet. 2: 1278, 1981.

    Article  PubMed  CAS  Google Scholar 

  20. Tamaki H., Amino N., Takeoka K., Mitsuda N., Miyai K., Tanizawa O. Thyroxine requirement during pregnancy for replacement therapy of hypothyroidism. Obstet. Gynecol. 76: 230, 1990.

    PubMed  CAS  Google Scholar 

  21. Amino N., Miyai K. Postpartum autoimmune endocrine syndromes. In: T. Davies (Ed.), Autoimmune endocrine disease. John Wiley & Sons, New York, 1983, p. 247.

    Google Scholar 

  22. Amino N., Mori H., Iwatani Y., Tanizawa O., Kawashima M., Tsuge I., Ibaragi K., Kumahara Y., Miyai K. High prevalence of transient postpartum thyrotoxicosis and hypothyroidism. N. Engl. J. Med. 306: 849, 1982.

    Article  PubMed  CAS  Google Scholar 

  23. Sawin C., Smallridge R. Postpartum thyroid disease. Endocrinologist 2: 358, 1992.

    Article  Google Scholar 

  24. Jansson R., Bernander S., Karlsson A., Zelvin K., Nilsson G. Autoimmune thyroid dysfunction in the postpartum period. J. Clin. Endocrinol. Metab. 58: 681, 1984.

    Article  PubMed  CAS  Google Scholar 

  25. Walfish P., Chan J. Postpartum hyperthyroidism. Clin. Endocrinol. Metab. 14: 417, 1985.

    Article  PubMed  CAS  Google Scholar 

  26. Walfish P., Meyerson J., Provias J., Vargas M., Papsis F. Prevalence and characteristics of post-partum thyroid dysfunction: Results of a survey from Toronto, Canada. J. Endocrinol. Invest. 15: 265, 1992.

    Article  PubMed  CAS  Google Scholar 

  27. Freeman R., Rosen H., Thysen B. Incidence of thyroid dysfunction in an unselected postpartum population. Arch. Intern. Med. 146: 1361, 1986.

    Article  PubMed  CAS  Google Scholar 

  28. Nikolai T.F., Turney S.L., Roberts R.C. Postpartum lymphocytic thyroiditis. Prevalence, clinical course, and long-term follow-up. Arch. Intern. Med. 147: 221, 1987.

    Article  PubMed  CAS  Google Scholar 

  29. Lervang H.H., Pryds O., Ostergaard K.H. Thyroid dysfunction after delivery: incidence and clinical course. Acta Med. Scand. 222: 369, 1987.

    Article  PubMed  CAS  Google Scholar 

  30. Lübig H., Bohn W., Mau J., Schats H. Prevalence of postpartum thyroiditis in two Iodine-deficient regions of Germany. In: W. Scherbaum, U. Bogner, B. Weinheimer, G. Bottazzo (Ed.), Autoimmune thyroiditis. Springer-Verlag, Berlin, 1991, p. 185.

    Chapter  Google Scholar 

  31. Fung H.Y., Kologlu M., Collison K., John R., Richards C.J., Hall R., McGregor A.M. Postpartum thyroid dysfunction in Mid Glamorgan. Br. Med. J. Clin. Res. Ed. 296: 241, 1988.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  32. Rasmussen N., Hornnes P., Hoiter-Madsen M., Feldt-Rasmussen U., Hegedus L. Thyroid size and function in healthy pregnant women with thyroid autoantibodies. Acta Endocrinol. (Copenh.) 123: 395, 1990.

    CAS  Google Scholar 

  33. Rajatanavin R., Chailurkit L.O., Tirarungsikul K., Chalayondeja W., Jittivanich U., Puapradit W. Postpartum thyroid dysfunction in Bangkok: a geographical variation in the prevalence. Acta Endocrinol. (Copenh.) 122: 283, 1990.

    CAS  Google Scholar 

  34. Roti E., Bianconi L., Gardini E., Minelli R., De F.M., Bacchi M.A., Bresciani D., Villa P., Neri T.M., Savi M. Postpartum thyroid dysfunction in an Italian population residing in an area of mild iodine deficiency. J. Endocrinol. Invest. 14: 669, 1991.

    Article  PubMed  CAS  Google Scholar 

  35. Stagnaro-Green A., Roman S., Cobin R., el-Harazy H., Wallenstein S., Davies T. A prospective study of lymphocyte-initiated immunosuppression in normal pregnancy: Evidence of a T-cell etiology for postpartum thyroid dysfunction. J. Clin. Endocrinol. Metab. 74: 645, 1992.

    PubMed  CAS  Google Scholar 

  36. Alvarez M.M., Roman S.H., Drexler A.J., Robertson C., Stagnaro G.A. Long-term prospective study of postpartum thyroid dysfunction in women with insulin dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 79: 10, 1994.

    Google Scholar 

  37. Bech K., Hoier M.M., Feldt R.U., Jensen B.M., Molsted P.L., Kuhl C. Thyroid function and autoimmune manifestations in insulin-dependent diabetes mellitus during and after pregnancy. Acta Endocrinol. (Copenh.) 124: 534, 1991.

    CAS  Google Scholar 

  38. Gerstein H.C. Incidence of postpartum thyroid dysfunction in patients with type I diabetes mellitus. Ann. Intern. Med. 118: 419, 1993.

    Article  PubMed  CAS  Google Scholar 

  39. Amino N., Tanizawa O., Miyai K., Tanaka F., Hayashi C., Kawashima M., Ichihara K. Changes of serum immunoglobulins IgG, IgA, IgM and IgE during pregnancy. Obstet. Gynecol. 52: 415, 1978.

    PubMed  CAS  Google Scholar 

  40. Hidaka Y., Amino N., Iwatani Y., Kaneda T., Nasu M., Mitsuda N., Tanizawa O., Miyai K. Increase in peripheral natural killer cell activity in patients with autoimmune thyroid disease. Autoimmunity 11: 239, 1992.

    Article  PubMed  CAS  Google Scholar 

  41. Amino N., Miyai K., Kuro R., Tanizawa O., Azukizawa M., Takai S., Tanaka F., Nlshi K., Kawashima M., Kumahara Y. Transient postpartum hypothyroidism: Fourteen cases with autoimmune thyroiditis. Ann. Intern. Med. 87: 155, 1977.

    Article  PubMed  CAS  Google Scholar 

  42. Stagnaro-Green A. Post-miscarriage thyroid dysfunction. Obstet. Gynecol. 80: 490, 1992.

    PubMed  CAS  Google Scholar 

  43. Hidaka Y., Tamaki H., Iwatani Y., Tada H., Mitsuda N., Amino N. Prediction of postpartum onset of Graves’ thyrotoxicosis by measurement of thyroid stimulating antibody in early pregnancy. Clin. Endocrinol. 41: 15, 1994.

    Article  CAS  Google Scholar 

  44. Amino N., Yabu Y., Miyai K., Fujie T., Azukizawa M., Onishi T., Kumahara Y. Differentiation of thyrotoxicosis induced by thyroid destruction from Graves’ disease. Lancet 2: 344, 1978.

    Article  PubMed  CAS  Google Scholar 

  45. Hidaka Y., Nishi I., Tamaki H., Takeoka K., Tada H., Mitsuda N., Amino N. Differentiation of the postpartum thyrotoxicosis by serum thyroglobulin; Usefulness of the new multi-site immunoradiometric assay. Thyroid. 4: 275, 1994.

    Article  PubMed  CAS  Google Scholar 

  46. Yoshida H., Amino N., Yagawa K., Uemura K., Satoh M., Miyai K., Kumahara Y. Association of serum antithyroid antibodies with lymphocytic infiltration of the thyroid gland: studies of seventy autopsied cases. J. Clin. Endocrinol. Metab. 46: 859, 1978.

    Article  PubMed  CAS  Google Scholar 

  47. Amino N., Hagan S., Yamada N., Refetoff S. Measurement of circulating thyroid microsomal antibodies by tanned red cell hemmagglutination technique: Its usefullness in the diagnosis of autoimmune thyroid diseases. Clin. Endocrinol. 5: 115, 1978.

    Article  Google Scholar 

  48. Tachi J., Amino N., Iwatani Y., Tamaki H., Mori M., Aozasa M., Tanizawa O., Miyai K. Increase in antideoxyribonucleic acid antibody titer in postpartum aggravation of autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 67: 1049, 1988.

    Article  PubMed  CAS  Google Scholar 

  49. Tada H., Hidaka Y., Itoh E., Kashiwai T., Tamaki H., Iwatani Y., Amino N. Prevalence of postpartum onset of disease within patients with Graves’ disease of child-bearing age. Endocr. J. 41: 325, 1994.

    Article  PubMed  CAS  Google Scholar 

  50. Kasagi K., Hatabu H., Tokuda Y., lida Y., Endo K., Konishi J. Studies on thyrotrophin receptor antibodies in patients with euthyroid Graves’ disease. Clin. Endocrinol. 29: 357, 1988.

    Article  CAS  Google Scholar 

  51. Tamaki H., Amino N., Aozasa M., Mori M., Tanazawa O., Miyai K. Serial changes in thyroid-stimulating antibody and thyrotropin binding inhibitor immunoglobulin at the time of postpartum occurrence of thyrotoxicosis in Graves’ disease. J. Clin. Endocrinol. Metab. 65: 324, 1987.

    Article  PubMed  CAS  Google Scholar 

  52. Tamaki H., Amino N., Aozasa M., Mori M., Iwatani Y., Tachi J., Nose O., Tanizawa O., Miyai K. Effective method for prediction of transient hypothyroidism in neonates born to mothers with chronic thyroiditis. Am. J. Perinatol. 6: 296, 1989.

    Article  PubMed  CAS  Google Scholar 

  53. Tamaki H., Amino N., Aozasa M., Mori M., Iwatani Y., Tachi J., Nose O., Tanizawa O., Miyai K. Universal predictive criteria for neonatal overt thyrotoxicosis requiring treatment. Am. J. Perinatol. 5: 152, 1988.

    Article  PubMed  CAS  Google Scholar 

  54. Tamaki H., Amino N., Watanabe Y., Aozasa M., Hayashi H., Tachi J., Miyai K. Radioreceptor assay of anti-TSH receptor antibody activity: Comparison of assays using unextracted serum and immunoglobulin fractions, and standardization of expression of activities. J. Clin. Lab. Immunol. 20: 1, 1986.

    PubMed  CAS  Google Scholar 

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Amino, N., Tada, H. & Hidaka, Y. Autoimmune thyroid disease and pregnancy. J Endocrinol Invest 19, 59–70 (1996). https://doi.org/10.1007/BF03347860

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