Skip to main content

Advertisement

SpringerLink
Log in

Langerhans cell histiocytosis, diabetes insipidus, hyperprolactinemia and empty sella: A four-fold association. Report of two cases

  • Case Report
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

Two cases of Langerhans cell histiocytosis (LCH) expressing as Hand-Schuller-Christian syndrome with diabetes insipidus, hyperprolactinemia and empty sella are here reported. Up-to-date this four-fold association is lacking in world literature and it is here discussed in the light if LCH is a cancer or the clinical expression of an immunologic disorder.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Lichtenstein L. Histiocytosis X: integration of eosinophilic granuloma of bone, “Letterer Siwe disease”, and “Schuller - Christian disease” as related manifestations of a single nosologic entity. Arch Pathol. 56: 84, 1953.

    CAS  Google Scholar 

  2. The Writing Group of the Histiocyte Society. Histiocytosis syndromes in children. Lancet 1: 208, 1987.

    Google Scholar 

  3. Braustein G.D., Kohler P.O. Endocrine manifestations of histiocytosis. Am. J. Pediatr. Hematol. Oncol. 3: 67, 1991.

    Google Scholar 

  4. Matisonn R., Pimstone B. Diabetes insipidus associated with an empty sella turcica. Postgrad. Med. J. 48: 274, 1973.

    Article  Google Scholar 

  5. Schaison G., Hetzger J. The primary empty sella: endocrine study of 12 cases. Acta Endocrinol. (Copenh.) 83: 483, 1976.

    CAS  Google Scholar 

  6. Manelfe C., Louvet J.P. Computed tomography in diabetes insipidus. J. Comput. Assist. Tomogr. 3: 306, 1979.

    Article  Google Scholar 

  7. Cupps T.R., Woolf P.O. Primary empty sella syndrome with panhypopituitarism, diabetes insipidus and visual field defects. Acta Endocrinol. (Copenh.) 89: 445, 1978.

    CAS  Google Scholar 

  8. Marano G.D., Horton J.A., Vazquez A.M. Computed tomography in diabetes insipidus: posterior empty sella. Br. J. Radiol. 54: 263, 1991.

    Article  Google Scholar 

  9. Greger U.G., Kirkland R.T., Kirkland J.L., Clayton G.W. Central diabetes insipidus: twenty years experience 1963–1983. Clin. Res. 31: 894A, 1983.

    Google Scholar 

  10. Vanini R., Lambiase R., Bianchi C., Di Natale B. Diabetes insipidus associated with empty sella turcica in a child. Min. Pediatr. 33: 541, 1981.

    CAS  Google Scholar 

  11. Pudakka K., Korhonen T., Lahtinen R. Diabetes insipidus in preleukemia phase of acute myeloid leukemia in 2 patients with empty sella turcica. Scand. J. Haematol. 32: 364, 1984.

    Google Scholar 

  12. Lambert M., Gaillard R.C., Vallotton M.B., Megret M., Delavelle S. Empty sella syndrome associated with diabetes insipidus: case report and review of the literature. J. Endocrinol. Invest. 12: 433, 1989.

    Article  PubMed  CAS  Google Scholar 

  13. Osella G., Terzolo M., Caraci P., Orlandi F., Angeli A. Diabetes insipidus associated with empty sella: report of two cases. J. Endocrinol. Invest. 13: 351, 1990.

    Article  PubMed  CAS  Google Scholar 

  14. Caron P., Bennet A., Manelfe C., Louvet J.P. Partial diabetes insipidus and empty sella in histiocytosis X. Rev. Med. Intern. 9: 181, 1988.

    Article  CAS  Google Scholar 

  15. De Bellis A., Bizzarro A., Amoresano Paglionico V., Di Martino S., Criscuolo T., Sinisi A.A., Lombardi G., Bellastella A. Detection of vasopressin cells antibodies in some patients with autoimmune endocrine disease without overt diabetes insipidus. Clin. Endocrinol. (Oxf.) 40: 173, 1994.

    Article  Google Scholar 

  16. Mauerhoff T., Mirakian R., Bottazzo G.F. Autoimmunity and the pituitary. Bailiere’s Clin. Immunol. All. 1: 217, 1987.

    Google Scholar 

  17. Naruse M., Demura E., Shizume K., Wakabayashi J., Naruse K., Tsunoda S., Demura K. A case of histiocytosis X associated with panhypopituitarism and hypergammaglobulinemia G and E. Endocrinol. Jpn. 26: 291, 1979.

    Article  PubMed  CAS  Google Scholar 

  18. Matsukura S., Imura K. Diabetes insipidus, galactorrhea caused by histiocytosis X. Endocrinol. Jpn. 22: 311, 1975.

    Article  PubMed  Google Scholar 

  19. Tabarin A., Corcuff J.B., Dautheribes M., Merlio J.P., Cochet C., Maire J.P., Larail C., Roger P. Histiocytosis X of the hypothalamus. J. Endocrinol. Invest. 14: 139, 1991.

    Article  PubMed  CAS  Google Scholar 

  20. Pizzo P.A., Popfack D.G., Horowitz M.E., Hays D.M., Kun L.E. The Histiocytosis in Cancer: Principles and Practice of Oncology, ed. 4. J.B. Lippincot-Co, Philadelphia 1993, p. 1786.

    Google Scholar 

  21. Perreault C., Pelletier M., Landry D., Gyger M. Study of Langerhans cells after allogeneic bone marrow transplantation. Blood 63: 807, 1984.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Settore di Immunologia ed Endocrinologia Oncologica, Divisione di Oncologia Medica, Ospedale A. Cardarelli, Italy

    G. Lodice

  2. Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Université “Federico II”, Italy

    B. Merola, A. Colao &  Gaetano Lombardi

  3. istituto di Endocrinologia, Cattedra di Fisiopatologia Clinica, II Università, Napoli, Italy

    N. Panza, A. de Bellis & A. Bellastella

Authors
  1. N. Panza
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Merola
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Colao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Lodice
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. de Bellis
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Bizzarro
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. Bellastella
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Gaetano Lombardi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Panza, N., Merola, B., Colao, A. et al. Langerhans cell histiocytosis, diabetes insipidus, hyperprolactinemia and empty sella: A four-fold association. Report of two cases. J Endocrinol Invest 19, 43–47 (1996). https://doi.org/10.1007/BF03347857

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03347857

Key-words

Search

Navigation