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Riedel’s thyroiditis associated with high titers of antimicrosomal and antithyroglobulin antibodies and hypothyroidism

Abstract

Riedel’s thyroiditis is a rare, chronic inflammatory disease of the thyroid gland. The aggressive fibrosis with extension beyond the thyroid into adjacent tissues contrasts with the diffuse, but intracapsular fibrosis of Hashimoto’s thyroiditis. Most current studies refute the possibility of progression from a highly fibrosing form of Hashimoto’s thyroiditis to a Riedel’s thyroiditis based on the distinct clinical and laboratory data, although an unknown immunological basis is suggested for both diseases. The authors describe a patient with Riedel’s thyroiditis, probably associated with Hashimoto’s thyroiditis, sent to surgery because her cytological examination suggested thyroid malignancy. This patient had clinical and laboratory features of hypothyroidism and very high titers of antimicrosomal and antithyroglobulin antibodies, which decreased after surgery. Pathology studies disclosed Riedel’s thyroiditis with intense lymphocytic infiltration suggestive of Hashimoto’s thyroiditis. Quantitative immunohistochemical studies were not able to distinguish between both diseases.

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References

  1. 1.

    Riedel B.M. Die chronische zur Bildung eisenharter Tumoren fuhrende Entzundung der Schilddruse. Vern. dt. Ges. Chir. 25: 101, 1896.

    Google Scholar 

  2. 2.

    Volpe R. Invasive Fibrous (Riedel’s) Thyroiditis In: Burrow G.N., Oppenheimer J.H., Volpe R. (Eds.), Thyroid function and disease. W.B. Saunders Company, Philadelphia, 1989, p. 208.

    Google Scholar 

  3. 3.

    Hay I.D. Thyroiditis: a clinical update. Mayo Clin. Proc. 60: 836, 1985.

    CAS  PubMed  Article  Google Scholar 

  4. 4.

    Li Volsi V.A. Fibrosis in the thyroid. In: Li Volsi V.A. (Ed.), Surgical Pathology of the Thyroid. W.B. Saunders Company, Philadelphia, 1990, p. 98.

    Google Scholar 

  5. 5.

    Hashimoto H. Zur Kenntnis der Lymphomatosen Veranderung der Schildruse (Struma Lymphomatosa). Arch. Klin. Chir. 97: 219, 1912.

    Google Scholar 

  6. 6.

    Woolner L.B., McConahey W.M., Beahrs O.H. Invasive fibrous thyroiditis (Riedel’s struma). J. Clin. Endocrinol. Metab. 17: 201, 1957.

    PubMed  Article  Google Scholar 

  7. 7.

    Katz S.M., Vickery A.L. The fibrous variant of Hashimoto’s thyroiditis. Hum. Pathol. 5: 161, 1974.

    CAS  PubMed  Article  Google Scholar 

  8. 8.

    Oertel J.E., Li Volsi V.A. Pathology of thyroid disease. In: Ingbar S.H., Bravermann L.E. (Eds.), Werner’s The thyroid. A fundamental and clinical text. J.B. Lippincott Company, Philadelphia, 1986, p. 658.

    Google Scholar 

  9. 9.

    McGregor A.M., Hall R. Thyroiditis. In: De Groot L.J. (Ed.), Endocrinology. W.B. Saunders Company, Philadelphia, 1989, p. 683.

    Google Scholar 

  10. 10.

    Merrington W.R. Chronic thyroiditis: a case showing features of both Riedel’s and Hashimoto’s thyroiditis. Br. J. Surg. 35: 423, 1948.

    CAS  PubMed  Article  Google Scholar 

  11. 11.

    Schwaegerle S.M., Bauer T.W., Esselstyn C.B. Riedel’s thyroiditis. Am. J. Clin. Pathol. 90: 715, 1988.

    CAS  PubMed  Google Scholar 

  12. 12.

    Hay I.D., McConahey W.M., Carney J.A., Woolner L.B. Invasive fibrous thyroiditis (Riedel’s struma) and associated extracervical fibrosclerosis: Bowlby’s disease revisited. Ann. Endocrinol. (Abstract) 43: 29A, 1982.

    Google Scholar 

  13. 13.

    Beierwaltes W. Thyroiditis. Ann. N.Y. Acad. Sci. 124: 586, 1965.

    CAS  PubMed  Article  Google Scholar 

  14. 14.

    Harach H.R., Williams E.D. Fibrous thyroiditis-an immunological study. Histopathology 7: 739, 1983.

    CAS  PubMed  Article  Google Scholar 

  15. 15.

    Munro J.M., Van Der Walt J.D., Cox E.L. A comparison of cytoplasmatic immunoglobulins in retroperitoneal fibrosis and abdominal aortic aneurysms. Histopathology 10: 1163, 1986.

    CAS  PubMed  Article  Google Scholar 

  16. 16.

    Marin F., Araújo R., Paramo C., Lucas T., Salto L. Riedel’s thyroiditis associated with hypothyroidism and hypoparathyroidism. Postgrad. Med. J. 65: 381, 1989.

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  17. 17.

    KiniS. R. Thyroiditis. In: Kini S.R. (Ed), Guides to clinical aspiration biopsy thyroid. Igaku-Shoin, New York, 1987, p. 235.

    Google Scholar 

  18. 18.

    Worstman J., Dietrich J., Apesus J., Folse R. Hashimoto’s thyroiditis simulating cancer of the thyroid. Arch. Surg. 116: 386, 1981.

    Article  Google Scholar 

  19. 19.

    Bowlby A.A. Diseases of the ductless glands. Infiltrating fibroma (?sarcoma) of the thyroid gland. Trans. Pathol. Soc. (London) 36: 420, 1885.

    Google Scholar 

  20. 20.

    Hadley J., Coady A.T., Milford C.A. Pseudotumor of the maxillary antrum. J. Laryngol. Otol. 104: 244, 1990.

    CAS  PubMed  Article  Google Scholar 

  21. 21.

    Sclare G., Luxton W. Fibrosis of the thyroid and lacrimal glands. Br. J.Ophtalm. 51: 173, 1967.

    CAS  Article  Google Scholar 

  22. 22.

    Miro I., Bakir R., Chanu B., Brocheriou C., Brenot F., Rouffy J. Thyroídite de Riedel et fibrose rétropéritonéale. Ann. Med. Interne 135: 212, 1984.

    CAS  Google Scholar 

  23. 23.

    Westhoff M. Riedel-Struma und fibrose Mediastinitis. Dtsch. Med. Wschr. 113: 337, 1988.

    CAS  PubMed  Article  Google Scholar 

  24. 24.

    Bartholomew L.G., Cain J.C., Woolner L.B., Utz D.C., Ferris D.O. Sclerosing cholangitis: its possible association with Riedel’s struma and fibrous retroperitonitis: report of two cases. N. Engl. J. Med. 269: 8, 1963.

    CAS  PubMed  Article  Google Scholar 

  25. 25.

    Hines R.C., Scheuermann H.A., Royster H.P., Rose E. Invasive fibrous (Riedel’s thyroiditis) with bilateral fibrous parotitis. JAMA 213: 869, 1970.

    CAS  PubMed  Article  Google Scholar 

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Correspondence to F. Zelmanovitz.

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Zelmanovitz, F., Zelmanovitz, T., Beck, M. et al. Riedel’s thyroiditis associated with high titers of antimicrosomal and antithyroglobulin antibodies and hypothyroidism. J Endocrinol Invest 17, 733–737 (1994). https://doi.org/10.1007/BF03347770

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Key-words

  • Riedel’s thyroiditis
  • antimicrosomal antibodies
  • antithyroglobulin antibodies
  • hypothyroidism