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Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin

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References

  1. Muir A., Luchetta R., Schatz D. Insulin-specific immunotheraphy ameliorates diabetes in non-obese diabetic (NOD) mice. Diabetes 41S 1: 39A, 1992.

    Google Scholar 

  2. Sayegh M.H., Khoury S.J., Hancock W.W., Weiner H.L., Carpenter C.B. Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat. Proc. Natl. Acad. Sci. USA 89: 7762, 1992.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Weiner H.L. Treatment of autoimmune diseases by oral tolerance to autoantigens. Autoimmunity 15S: 6, 1993.

    Article  Google Scholar 

  4. Miller A., Lider O., Roberts A.B., Sporn M., Weiner H.L Suppressor T cells generated by oral toleration to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor ß after antigen-specific triggering. Proc. Natl. Acad. Sci. USA 89: 421, 1992.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Atkinson M.A., Maclaren N.L., Luchetta R. Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes 39: 933, 1990.

    Article  CAS  PubMed  Google Scholar 

  6. Thivolet C.H., Goillot E., Durand A., Bonnard M., Orgiazzi J. Insulin prevents adoptive transfer of diabetes in the autoimmune non-obese diabetic mouse. Diabetologia 34: 314, 1991.

    Article  CAS  PubMed  Google Scholar 

  7. Muir A., Luchetta R., Song H.-Y., Peck A., Krisher J., Maclaren N.K. Insulin immunization prevents NOD mice from diabetes. Proceedings of the 12th Immunology and Diabetes Workshop 60, 1993.

  8. Ziegler A.G., Vardi P., Ricker A.T., Hattori M., Soeldner J.S., Eisenbarth G.S. Radioassay determination of insulin autoantibodies in NOD mice. Correlation with increased risk of progression to overt diabetes. Diabetes 38: 358, 1989.

    CAS  Google Scholar 

  9. Takeda J., Yano H., Eng S., Zeng Y., Bell G.I. A molecular inventory of human pancreatic islets: Sequence analysis of 1000 cDNA clones. Hum. Mol. Genet. 2: 1793, 1993.

    Article  CAS  PubMed  Google Scholar 

  10. Weiner H.L., Mackin G.A., Matsui M., Orav E.J., Khoury S.J., Dawson D.M., Hafler D.A. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science 259: 1321, 1993.

    Article  CAS  PubMed  Google Scholar 

  11. Trentham D.E., Dynesius-Trentham R.A., Orav E.J., Combitchi D., Lorenzo C., Sewell K.L., Hafler D.A., Weiner H.L. Effects of oral administration of type II collagen on rheumatoid arthritis. Science 261: 1727, 1993.

    Article  CAS  PubMed  Google Scholar 

  12. Autoimmune diseases: treating arthritis with tolerance. Science 261: 1669, 1993.

    Article  Google Scholar 

  13. Miller A., Al-Sabbagh A., Santos L.M.D., Das M.B., Weiner H.L. Epitopes of myelin basic protein that trigger TGF-ß release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression. J. Immunol. 151: 7307, 1993.

    CAS  PubMed  Google Scholar 

  14. Khoury S.J., Hancock W.W., Weiner H.L. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor ß, interleukin 4 and prostaglandin E expression in the brain. J. Exp. Med. 176: 1355, 1992.

    Article  CAS  PubMed  Google Scholar 

  15. Eisenbarth G.S., Verge C.F., Allen H., Rewers M.J. Perspective in diabetes: the design of trials for prevention of IDDM. Diabetes 42: 941, 1993.

    Article  CAS  PubMed  Google Scholar 

References

  1. Eisenbarth G.S. Type I Diabetes mellitus. A Chronic autoimmune disease. N. Engl. J. Med. 314, 1380, 1886.

    Google Scholar 

  2. Castano L., Eisenbarth G.S. Type I diabetes mellitus: a chronic autoimmune disease of human, mouse and ret. In: Annual Review of Immunology. Paul W.E., Eisenbarth G.S., and Metzger H. (Eds.). Annual Reviews Inc., Palo Alto, pp. 847–879, 1990.

    Google Scholar 

  3. Lampater E.F., Signore A., Gala E.A.M., Pozzilli P. Lassons from the NOD mouse for the pathoganesid and immunotherapy of human type I (insulin-dependent) diabetes mellitus. Diabetologia 32: 703, 1988.

    Article  Google Scholar 

  4. Andreani D., DiMario U., Pozzilli P. Prediction, prevention, and early intervention in insulin-dependent diabetes. Diabetes/Metabolism Reviews 7: 61, 1991.

    Article  CAS  PubMed  Google Scholar 

  5. Boitard C. The differentation of the immune system towards anti-islet autoimmunity. Clinical prospects, Diabetologia 38: 1101, 1992.

    Article  Google Scholar 

  6. Srikanta S., Ganda O., Gleason R.E., Jackson R.A., Soeldner J.S., Eisenbarth G.S. Pre-type I diabetes: linear of ß-cell response to intravenous glucosa. Diabetes, 33: 717, 1984.

    Article  CAS  PubMed  Google Scholar 

  7. Boitard C., Timait J., Sempe P., Bach J.-F. Experimental Immunoprevention of type I diabetes. Diabetes/Metabolism Reviews 7: 15, 1991.

    Article  CAS  PubMed  Google Scholar 

  8. Zhang S.J., Lae C.S.Y., Lider O., Weiner H.L. Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen. J. Immuinol. 145: 2489, 1990.

    CAS  Google Scholar 

  9. Nussenblatt R.B., Caspi R.R., Mahdi et al. Inhibition of S-antigen induced experimental autoimmune uveoratinitis by oral induction of tolerance with S-antigen. J. Immunol 144: 1688, 1990.

    Google Scholar 

  10. Lider O., Santos L.M.S., Lee C.S.Y., Higgins D.J., Wniner H.L. Suppression of experimental autoimmune encaphalomyelitis by oral administertion of myelin basic protein II. Suppression of disease and in vitro response is mediated by CD8+ T lymphocytes. J. Immunol. 142, 1989.

  11. Vardi P., Dib S.A., Tuttiaman M., Connelly J.F., Grinbergs M., Rabizadeh A., Riley W.J., Maclaren N.K., Eisenbarth G.S., Soaldner J.S. Competitive insulin autoantibody RIA: Prospective evaluation of subjects at high risk for development of type I diabetes mellitus. Diabetes 38: 1288, 1987.

    Google Scholar 

  12. Baekkookov S.H., Annstoot S., Christgan A., et al. Identification of the 64kd autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid deoarboxylase. Natura, (London) 347: 151, 1990.

    Article  Google Scholar 

  13. Pietropaolo M., Castano L., Babo S., Suelow R., Martin S., Martin A., Powaec A., Prochazka M., Naggert J., Leiter E.H., Eisenbarth G.S. Islet cell autoantigens 69 koa (ICA69): Molecular clonning and cheraotarization of a nova diabetes associated autoantigen. J. Clin. Incoot 92: 359, 1993.

    Article  CAS  Google Scholar 

  14. Castoro L., Russo E., Zhuu L., Lipes M.A., Eisenbarth G.S. Identification and clonning of a granule autoantigen (carboxypeptidase H) associated with type I diabetes J. Clin. Endoc. Metab. 73: 1197, 1991.

    Article  Google Scholar 

  15. Ihman L.R., MoAllister C.T., Chen L., Hughas S., Nawgard C.S., Kattman J.R., Unger R.H., Johnson J.H. Autoantibodies to the glut-2 gluppsa transporta of botA cells in insulin dependent diabetes mellitus of recent onset. Proc. Natl. Acad. Sci USA 90: 1281, 1993.

    Article  Google Scholar 

  16. Takei I., Kasatani T., Watanaba K., Kasuga A., Shimada A., Maruyams T., Garuta T., Nomagichi H. Detection of heat shock protein in patients with insulin dependent diabetes mellitus. Diabetes Ras. Clin. Pract. 21: 25, 1893.

    Article  Google Scholar 

  17. Miller A., Lider O., Weiner H.L. Antigen-driven bystander suppression following oral administration of antigens. J. Exp. Med. 174: 791, 1991.

    Article  CAS  PubMed  Google Scholar 

  18. Mowat A.M. The regulation of the immune responses to dietary protein antigens. Immunol. Today 8: 93, 1987.

    Article  CAS  Google Scholar 

  19. Saklayan M.S., Pesce A.J., Pollak V.E., Michael J.G. Kinetics of oral tolerance: study of variables affecting tolerance induced by oral administration of antigen. Int. Arch. Allergy Appl. Immunol. 73: 5, 1984.

    Article  Google Scholar 

  20. Miller A., Al-Sabbagh A., Santos L.M.B., Prabhu Das M., Wainer H.L. Epitopes of myelin basic protein that trigger TGF-ß release after oral tolerization are distinct from encephalitogenic apitopes and mediate epitope-driven bystander suppression. J. Immunol. 151: 7307, 1993.

    CAS  PubMed  Google Scholar 

  21. Mirouza J., Salam J.L., Pham T.C., Mendoza E., Orsetti A. Sustained insulin-induced remissions of juvenile diabetes by means of an external artificial pancreas. Diabetologia 14: 223, 1978.

    Article  Google Scholar 

  22. Granot M., Perlman R., Kanter Y., Abraham G., Barzilai D., Vardi P. The reaction to early glucose administration of young NOD mice, Diabetes (supp. 1) 41: 36A, 1992.

    Google Scholar 

  23. Renold A.E., Steinke J., Soeldner J.S., Antoniades H.N., Smith R.E. Immunological response to the prolanged administration of heterologous and homologous insulin in cattle. J. Clin. Invest. 45: 702, 1966.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Muir A., Luchetta R., Song H.-Y., Peck A., Krischer J., Maclaren N. Insulin immunization protects NOD mice from diabetes. 12th International Immunology of Diabetes Workshop, Orlando, 1993.

  25. Shah S.C., Malone J.I., Simpson N.E. A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus. N. Engl. J. Med. 320: 550, 1989.

    Article  CAS  PubMed  Google Scholar 

  26. Berthrand S., De Paepe M., Vigeant C., Yale J.F. Prevention of adoptive transfer in BB rats by prophylactic insulin treatment. Diabetes 41: 1273, 1992.

    Article  Google Scholar 

  27. Appel M.C., Dotta F., O’Neil J.J., Einsenbarth G.S. ß-cell activity regulates the expression of islet anti-genic determinants (abstract). Diabetologia 32: 461A, 1989.

    Google Scholar 

  28. Khoury S.J., Hancock W.W., Weiner H.L. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factors ß, interleukin 4, and prostaglandin E expression in the brain. J. Exp. Med. 176: 1355, 1992.

    Article  CAS  PubMed  Google Scholar 

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Zhang, J.Z., Davidson, L., Eisenbarth, G. et al. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. J Endocrinol Invest 17, 573–580 (1994). https://doi.org/10.1007/BF03347752

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