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Cytokines as mediators in the regulation of the hypothalamic-pituitary-adrenocortical function

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References

  1. Long W.M., Pons G.M., Sprung C.L. Metabolic and hormonal responses to injury and sepsis in the critically ill. In: Gleelhoed G.W., Chemow B. (eds) Endocrine aspects of acute illness. Churchill Livingstone, New York, 1, 1985.

    Google Scholar 

  2. Chrousos G.P., Gold P.W. The concepts of stress and stress system disorders. J. Am. Med. Assn. 267: 1244, 1992.

    CAS  Google Scholar 

  3. Munck A., Guyre P.M., Holbrook N.J. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr. Rev. 5: 25, 1984.

    PubMed  CAS  Google Scholar 

  4. Bateman A., Singh A., Kral T., Solomon S. The immune-hypothalamic-pituitary-adrenal axis. Endocr. Rev. 10: 92, 1987.

    Google Scholar 

  5. Imura H., Fukata J., Mori T. Cytokines and endocrine function: an interaction between the immune and neuroendocrine systems. Clin. Endocrinol. 35: 107, 1991.

    CAS  Google Scholar 

  6. Goldstein D., Gockerman J., Krishnan R., Ritchie J. Jr., Yso C.Y., Hood L.E., Ellinwood E., Laszlo J. Effects of gamma interferon on the endocrine system; results from a phase I study. Cancer Res 47: 6397, 1987.

    PubMed  CAS  Google Scholar 

  7. Muller H., Hammes E., Heimke C., Hess G. lnterferon-alfa-2-induced stimulation of ACTH and Cortisol secretion in man. Neuroendocrinology 54: 499, 1991.

    PubMed  CAS  Google Scholar 

  8. Lotze M.T., Matory Y.L., Ettinghausen S.E., Rayner A.A., Sharrow S.O., Seipp C.A., Custer M.C., Rosenberg S.A. In vivo administration of purified human interleukin-2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2. J. Immunol. 135: 2865, 1985.

    PubMed  CAS  Google Scholar 

  9. Michie H.R., Eberrlein T.J., Spriggs D.R., Manogue K.R., Cerami A., Wilmore D.W. Interleukin-2 initiates metabolic responses associated with critical illness in humans. Ann. Surg. 208: 493, 1988.

    PubMed Central  PubMed  CAS  Google Scholar 

  10. Denicoff K.D., Durkin T.M., Lotze M.T., Quinlan P.E., Davis C.L., Listwak S.J., Rosenberg S.A., Rubinow D.R. The neuroendocrine effects of interleukin-2 treatment. J. Clin. Endocrinol. Metab. 69: 402, 1989.

    PubMed  CAS  Google Scholar 

  11. Naito Y., Fukata J., Tominaga T., Masui Y., Hirai Y., Murakami N., Tamai S., Mori K., Imura H. Adrenocorticotropic hormone-releasing activities of interleukins in a homologous in vivo system. Biochem. Biophys. Res. Commun. 164: 1262, 1989.

    PubMed  CAS  Google Scholar 

  12. Sapolsky R., Rivier C., Yamamoto G., Plotsky P., Vale W. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238: 522, 1987.

    PubMed  CAS  Google Scholar 

  13. Naitoh Y., Fukata J., Tominaga T., Nakai Y., Tamai S., Mori K., Imura H. Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely moving rats. Biochem. Biophy. Res. Commun. 155: 1459, 1988.

    CAS  Google Scholar 

  14. Bernardini R., Kamilaris T.C., Calogero A.E., Johnson E.O., Gomez M.T., Gold P.W., Chrousos G.P. Interactions between tumor necrosis factor-α, hypothalamic corticotropin-releasing hormone, and adrenocorticotropin secretion in the rat. Endocrinology 126: 2876, 1990.

    PubMed  CAS  Google Scholar 

  15. Watanobe H., Takebe K. Intravenous administration of tumor necrosis factor-α stimulates corticotropin releasing hormone secretion in the push-pull cannulated median eminence of freely moving rats. Neuropeptide 22: 81, 1992.

    CAS  Google Scholar 

  16. Cambronero J.C., Rivas F.J., Borrell J., Guaza C. Interleukin-2 induces corticotropin-releasing hormone release from superfused rat hypothalami: Influence of glucocorticoids. Endocrinology 131: 677, 1992.

    PubMed  CAS  Google Scholar 

  17. Navarra P., Tsagarakis S., Faria M.S., Rees L.H., Bessor G.M., Grossman A.B. Interleukin-1 and -6 stimulates the release of corticitropin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway Endocrinology 128: 37, 1991.

    PubMed  CAS  Google Scholar 

  18. Farrar W.L. Endorphin modulation of lymphokine activity. Opioid peptides in the periphery. Fraioli F, Isidori A., Mazzetti M. eds. Elsevier Science Publishers B.V. 159, 1984.

  19. Brown S.L, Smith L.R., Blalock J.E. Interleukin 1 and interleukin 2 enhance proopiomelanocortin gene expression in pituitary cells. J. Immunol. 139: 3181, 1987.

    PubMed  CAS  Google Scholar 

  20. Fukata J., Usui T., Naitoh Y., Nakai Y., Imura H. Effects of recombinant human interleukin-α, -1ß, 2 and 6 on ACTH synthesis and release in the mouse pituitary tumour cell line AtT-20. J. Endocrinol. 122: 33, 1989.

    PubMed  CAS  Google Scholar 

  21. Kobayashi H., Fukata J., Tominaga T., Murakami N., Fukushima M., Ebisui O., Segawa H., Nakai Y., Imura H. Regulation of interleukin-1 receptors on AtT-20 mouse pituitary tumour cells. FEBS lett 298: 100, 1992.

    PubMed  CAS  Google Scholar 

  22. Blalock J.E., Harp C. Interferon and, adrenocorticotropic hormone induction of steroidogenesis, melanogenesis and antiviral activity. Arch. Virol. 67: 45, 1981.

    PubMed  CAS  Google Scholar 

  23. Tominaga T., Fukata J., Naito Y., Usui T., Murakami N., Fukushima M., Nakai Y., Hirai Y., Imura H. 1991 Prostaglandin-dependent in vitro stimulation of adrenocortical steroidogenesis by interleukins. Endocrinology 128: 526, 1991.

    PubMed  CAS  Google Scholar 

  24. Roh M.S., Drazenovih K.A., Barbose B.S., Dinarello C.A., Cobb C.F. Direct stimulation of adrenal cortex by interleukin-1 Surgery 102: 140, 1987.

    CAS  Google Scholar 

  25. Gwosdow A.R., O’Coonnell N.A., Speneer J.A., Kumar M.S.A., Agawal R.K., Bode H.H., Abou-Samra A.B. Interleukin-1-induced corticosterone release occurs by an adrenergic mechanism from rat adrenal gland. Am. J. Physiol. 263: E461, 1992.

    PubMed  CAS  Google Scholar 

  26. Artz E., Buric R., Stelzer G., Stalla J., Sauer J., Renner U., Stalla G.K. Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6. Endocrinology 132: 459, 1993.

    Google Scholar 

  27. Naito Y., Fukata J., Nakaishi S., Nakai Y., Hirai Y., Tamai S., Mori K., Imura H. Chronic effects of interleukin-1 on hypothalamus, pituitary and adrenal glands in rats. Neuroendocrinology 51: 637, 1990.

    PubMed  CAS  Google Scholar 

  28. Chambrier C., Mercatello A., Tognet E., Cottet-Emard J.M., Cohen R., Blay J.Y., Favrot M., Philip T., Beylot M. Hormonal and metabolic effects of chronic interleukin-2 infusion in cancer patients. J. Biol. Response Mod. 9: 251, 1990.

    PubMed  CAS  Google Scholar 

  29. Sweep C.G.J., van der Meer M.J.M., Hermus A.R.M.M., Smals A.G.H., van der Meer J.W.M., Pesman G.J., Willemsen S.J., Benraad T.J., Kloppenborg P.W.C. Chronic Stimulation of pituitary-adrenal axis in rats by interleukin ß infusion: in vivo and in vitro studies. Endocrinology 130: 1153, 1992.

    PubMed  CAS  Google Scholar 

  30. Derijk R., Berkenbosch F. Development and application of a radioimmunoassay to detect interleukin-1 in rat peripheral circulation. Am. J. Physiol. 263: E1092, 1992.

    PubMed  CAS  Google Scholar 

  31. Beutler B., Krochin N., Milsark I.W., Luedke C., Cerami A. Control of cachectin (tumor necrosis factor) synthesis: mechanism of endotoxin resistance. Science 232: 977, 1986.

    PubMed  CAS  Google Scholar 

  32. Arend W.P. Interleukin-1 receptor antagonist. A new member of the interleukin 1 family. J. Clin. Invest. 88: 1445, 1991.

    CAS  Google Scholar 

  33. Dinarello C.A., Wolff S.M. The role of interleukin-1 in disease. New Engl. J. Med. 328: 106, 1993.

    PubMed  CAS  Google Scholar 

  34. Svenson M., Poulsen L.K., Fomsgaard A., Bendtzen K. IgG autoantibodies against interleukin1 a in sera of normal individuals. Scand. J. Immunol. 29: 489, 1989.

    PubMed  CAS  Google Scholar 

  35. Fomsgaad A., Svenson M., Bendtzen K. Auto-antibodies to tumor necrosis factor α in healthy humans and patients with inflammatory diseases and Gram negative bacterial infection. Scand. J. Immunol. 30: 219, 1989.

    Google Scholar 

  36. Rubin L.A., Jay G., Nelson D.L. The released interleukin-2 receptor binds interleukin-2 efficiently. J. Immunol. 137: 3841, 1986.

    PubMed  CAS  Google Scholar 

  37. Loetscher H., Steinmetz M., Lesslauer W. Tumor necrosis factor: receptors and inhibitors. Cancer Cells 3: 221, 1991.

    PubMed  CAS  Google Scholar 

  38. Thorpe R., Wadhwa M., Bird C.R., Mire-Sluis A.R. Detection and measurement of cytokines. Blood Rev. 6: 133, 1992.

    PubMed  CAS  Google Scholar 

  39. Spinas G.A., Keller U., Brockhaus M. Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia. J. Clin. Invest. 92: 533, 1992.

    Google Scholar 

  40. Martich G.D., Danner R.L., Ceska M., Suffredini A.F. Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents. J. Exp. Med. 173: 1021, 1991.

    PubMed  CAS  Google Scholar 

  41. Spinas G.A., Bloesch D., Keller U., Zimmerli W., Cammisuli S. Pretreatment with ibuprofen augments circulating tumor necrosis factor-α, interleukin-6, and elastase during acute endotoxinemia. J. Infect. Dis. 163: 89, 1991

    PubMed  CAS  Google Scholar 

  42. Michie H.R., Spiggs D.R., Manogue K.A., Sherman M.L., Revhaug A., O’Dwyer ST., Arther K., Dinarello C.A., Cerami A., Wolff S.M., Kufe D.W., Wilmore D.W Tumor necrosis factor and endotoxin induce similar metabolic responses in human being. Surgery 104: 280, 1988.

    PubMed  CAS  Google Scholar 

  43. Bristow A.F., Mosley K., Poole S. Interleukin-1ß production in vivo and in vitro in rats and mice measured using specific immunoradiometric assays. J. Mol. Endocrinol. 7: 1, 1991.

    PubMed  CAS  Google Scholar 

  44. Lissoni P., Tancini G., Rovelli F., Cattaneo G., Arehili C., Barni S. Serum interleukin-2 levels in relation to the neuroendocrine status in cancer patients. Br. J. Cancer 62: 838, 1990.

    PubMed Central  PubMed  CAS  Google Scholar 

  45. Smith J.A., Telford R.D., Baker M.S., Hapel A.J., Weidemann M.J. Cytokine immunoreactivity in plasma does not change after moderate endurance exercise. J. Appl. Physiol. 73: 1396, 1992.

    PubMed  CAS  Google Scholar 

  46. Gudewill S., Pollmacher T., Vedder H., Schreiber W., Fassbender K., Holsboer F. Nocturnal plasma levels of cytokines in healthy men. Eur. Arch. Psychiatry Clin. Neurosci. 242: 53, 1992.

    PubMed  CAS  Google Scholar 

  47. Covelli V., Massari F., Fallacara C., Munno I., Jirillo E., Savastano S., Tommaselli A.P., Lombardi G. Interleukin-1 beta and beta-endorphin circadian rhythms are inversely related in normal and stress-altered sleep. Intern. J. Neurosci. 63: 299, 1992.

    CAS  Google Scholar 

  48. Cannon J.G., Dinarello C.A. Increased plasma interleukin-1 activity in women after ovulation. Science 227: 1247, 1985.

    PubMed  CAS  Google Scholar 

  49. Herbelin A., Nguyen A.T., Zingraff J., Urena P., Descamps-Latscha B. Influence of uremie and hemodialysis on circulating interleukin-1 and tumor necrosis factor α. Kidney Int. 37: 116, 1990.

    PubMed  CAS  Google Scholar 

  50. Cavaillon J.M., Poignet J.L., Fitting C., Delons S. Serum interleukin-6 in long term hemodialyzed patients. Nephron. 60: 307, 1992.

    PubMed  CAS  Google Scholar 

  51. Poole S., Bristow A.F., Selkirk S., Rafferty B. Development and application of radioimmunoassays for interleukin-1 α and interleukin -1 ß. J. Immunol. Method 116: 259, 1989.

    CAS  Google Scholar 

  52. Jyonouchi H., Voss R.M., Good R.A. IL-1-like activities present in murine amniotic fluid. A significantly larger amount of IL-1ß like activity is present in the amniotic fluid of autoimmune NZB mice. J. Immunol. 138: 3300, 1987.

    CAS  Google Scholar 

  53. Yasuda N., Greer A.N. Evidence that the hypothalamus mediates endotoxin stimulation of adrenocorticotropic hormone secretion. Endocrinology 102: 947, 1978.

    PubMed  CAS  Google Scholar 

  54. Rietschel E.T., Brade H. Bacterial endotoxins. Sci. Amer. 267: 26, 1992.

    Google Scholar 

  55. Michie H.R., Manogue K.R., Spriggs D.R., Revhaug A., O’Dwyer S., Dinarello C.A., Cerami A., Wolff S.M., Wilmore D.W. Detection of circulating tumor necrosis factor after endotoxin administration. N. Engl. J. Med. 373: 1481, 1988.

    Google Scholar 

  56. Santos A.A., Scheltinga M.A., Lynch E., Brown E.F., Lawton P., Chambers E., Browning J., Dinarello C.A., Wolff S.M., Wilmore D.W. Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia. Arch. Surg. 128: 138, 1993.

    PubMed  CAS  Google Scholar 

  57. Girardin E., Grau G.E., Dayer J.M., Roux-Lombard P., J5 Study Group, Lambert P.H. Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N. Engl. J. Med. 319: 397, 1988.

    PubMed  CAS  Google Scholar 

  58. Cannon J.G., Tompkins R.G., Gelfand J.A., Michie H.R., Stanford G.G., van der Meer J.W.M., Endres S., Lonnemann G., Corsetti J., Chernow B., Wilmore D.W., Wolff S.M., Burke J.F., Dinarello C.A. Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J. Infect. Dis. 161: 79, 1990.

    PubMed  CAS  Google Scholar 

  59. Leroux-Roels G., Offner F. Tumor necrosis factor in sepsis. JAMA 263: 1494, 1990.

    PubMed  CAS  Google Scholar 

  60. Calandra T., Baumgarthner J.D., Grau G.E. Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-α, and interferon γ in the serum of patients with septic shock. J. Infect. Dis. 161: 982, 1990.

    PubMed  CAS  Google Scholar 

  61. Zanetti G., Heumann D., Gerain J., Kohler J., Abbet P., Barras C., Lucas R., Glauser M.P., Baumgartner J.D. Cytokine production after intravenous or peritoneal gram negative bacterial challenge in mice. Comparative protective efficacy of antibodies to tumor necrosis factor-α and to lipopolysaccharide. J. Immunol. 140: 1890, 1992.

    Google Scholar 

  62. Waage A. Production and clearance of tumor necrosis factor in rats exposed to endotoxin and dexamethasone. Clin. Immunol. Immunopathol. 45: 348, 1987.

    PubMed  CAS  Google Scholar 

  63. Flohe S., Heinrich P.C., Schneider J., Wendel A., Flohe L. Time course of IL-6 and TNFα release during endotoxin-induced endotoxin tolerance in rats. Biochem. Pharmacol. 41: 1607, 1991.

    PubMed  CAS  Google Scholar 

  64. Ulich T.R., Guo K., Remick D., Del Castillo J., Yin S. Endotoxin-induced cytokine gene expression in vivo III. IL-6 mRNA and serum protein expression and the in vivo hematologic effects of IL-6. J. Immunol. 146: 2316, 1991.

    CAS  Google Scholar 

  65. Ertel W., Morrison M.H., Wang P., Ba Z.F., Ayala A.A., Chaudry I.H. The complex pattern of cytokines in sepsis. Association between prostaglandins, cachectin, and interleukins. Ann. Surg. 214: 141, 1991.

    CAS  Google Scholar 

  66. Mathison J.C., Wolfson E., Ulevitsh R.J. Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits. J. Clin. Invest. 88: 1925, 1988.

    Google Scholar 

  67. Roth J., Conn C., Kluger M.J., Zeisberger E. Release of interleukin-6 and tumor necrosis factor during lipopolysaccharide induced fever in guinea pigs. Lomax and Schonbaum eds. Thermoregulation: The pathophysiological basis of clinical disorders. S. Karger, Basel, 28, 1992.

    Google Scholar 

  68. Van Zee K.J., Kohno T., Fischer E., Rock C.S., Moldawer L.L., Lowry S.F. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor α in vitro and in vivo. Proc. Natl. Acad. Sci. USA 89: 4845, 1992.

    PubMed Central  PubMed  Google Scholar 

  69. Fukata J. Cytokines and the hypothalamic-pituitary-adrenal axis. In, Proceedings of the Ninth International Congress of Endocrinology, Parthenon Publishing, London, in press, 1993.

  70. Derijk R., Rooijen V.N., Tilders H.J.F., Besedovsky O.H., Rey D.A., Berkenbosch F. Selective depletion of macrophages prevents pituitary-adrenal activation in response to subpyrogenic, but not to pyrogenic, dose of bacterial endotoxin in rats. Endocrinology 129: 330, 1991.

    PubMed  CAS  Google Scholar 

  71. Evans G.F., Snyder E.Y., Butler L.D., Zuckerman S.H. Differential expression of interleukin-1 and tumor necrosis factor in murine septic shock models. Circ. Shock 29: 279, 1989.

    PubMed  CAS  Google Scholar 

  72. Engelberts I., von Asmuth E.J.U., van der Innden C.J., Buurman W.A. The interrelation between TNF, IL-6, and PAF secretion induced by LPS in an in vivo and in vitro murine model. Lymphokine Cytokine Res. 10: 127, 1991.

    PubMed  CAS  Google Scholar 

  73. Zukerman S.H., Shellhaas J., Butler L.D. Differential regulation of lipopolysaccharide-induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary-adrenal axis. Eur. J. Immunol. 19: 301, 1989.

    Google Scholar 

  74. Moldawer L.L., Gelin J., Schersten T., Lundholm K.G. Circulating interleukin-1 and tumor necrosis factor during inflammation. Am. J. Physiol. 253: R922, 1987.

    PubMed  CAS  Google Scholar 

  75. Ikejima T., Okusawa S., Van der Meer J.W.M., Dinarello C.A. Toxic shock syndrome is mediated by interleukin-1 and tumor necrosis factor. Rev. Infect. Dis. 11[Suppl 1]: S316, 1989.

    Google Scholar 

  76. Saukkonen K., Sande S., Cioffe S., Wolpe S., Sherry B., Cerami A., Tuomanen E. The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis. J. Exp. Med. 171: 439, 1990.

    PubMed  CAS  Google Scholar 

  77. Wakabayashi G., Gelfand J.A., Jung W.K., Connolly R.J., Burke J.F., Dinarello C.A. Staphlococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbit without endotoxemia. Comparison to Escherichia coli. J. Clin. Invest. 87: 1925, 1991.

    PubMed Central  PubMed  CAS  Google Scholar 

  78. Miethke T., Wahl C., Heeg K., Echtenacher B., Krammer P.H., Wagner H. T-cell mediated shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor. J. Exp. Med. 175: 91, 1992.

    PubMed  CAS  Google Scholar 

  79. Colletti L.M., Remick D.G., Burtch G.D., Kunkel S.I., Strieter R.M., Campbell D.A. Jr. Role of tumor necrosis factor a in the pathophysiologic alternations after hepatic ischemia/reperfusion injury in the rat. J. Clin. Invest. 85: 1936, 1990.

    PubMed Central  PubMed  CAS  Google Scholar 

  80. Levine B., Kahlman J., Mayer L., Fillit H.M., Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N. Engl. J. Med. 323: 236, 1990.

    PubMed  CAS  Google Scholar 

  81. Ertel W., Meldrum D.R., Morison M.H., Ayala A., Chaudry I.H. Immunoprotective effect of a calcium channel blocker on macrophage antigen presentation function, major histocompatibility class II antigen expression and interleukin-1 synthesis after hemorrhage. Surgery 108: 154, 1990.

    PubMed  CAS  Google Scholar 

  82. Maury C.P.J., Salo E., Pelkonen P. Circulating interleukin-1 in patients with Kawasaki disease. N. Engl. J. Med. 319: 1670, 1988.

    PubMed  CAS  Google Scholar 

  83. Furukawa S., Matsubara T., Jujoh K., Yone K., Sugawara T., Sasai K., Kato H., Yabuta K. Peripheral blood monocyte/macrophage and serum tumor necrosis factor in Kawasaki disease. Clin. Immunol. Immunopathol. 48: 247, 1988.

    PubMed  CAS  Google Scholar 

  84. Rowley A.H., Shulman S.T., Preble O.T., Poiesz B.J., Ehrlich G.D., Sullivan J.R. Serum interferon concentrations and retroviral serology in Kawasaki syndrome. Pediatr. Infects. Dis. 7: 663, 1988.

    CAS  Google Scholar 

  85. Ho D., Pomerantz R., Kaplan J. Pathogenesis of infection with human immunodeficiency virus. N. Engl. J. Med. 317: 278, 1987.

    PubMed  CAS  Google Scholar 

  86. Dinarello C.A. Interleukin-1 and the pathogenesis of acute phase response. N. Engl. J. Med. 311: 1413, 1984.

    PubMed  CAS  Google Scholar 

  87. Lahdevista J., Maury C.P.J., Teppo A., Repo H. Elevated levels of circulating cachectin tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am. J. Med. 85: 289, 1988.

    Google Scholar 

  88. Ho-Yen D.O., Carrington D., Armstrong A.A. Myalgic encephalomyelitis and alpha-interferon. Lancet I: 125, 1988.

    Google Scholar 

  89. Demitrack M., Dale J.K., Straus S.E., Laue L., Listwak. S.J., Kruesi M.L.P., Chrousos G.P., Gold P.W. Evidence for the impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome. J. Clin. Endocrinol. Metab. 73: 1224, 1991.

    PubMed  CAS  Google Scholar 

  90. Verges B., Chavanet P., Desgres J., Vaillant G., Waldner A., Brun J.M., Putelat R. Adrenal function in HIV infected patients. Acta Endocrinol. 121: 633, 1989.

    PubMed  CAS  Google Scholar 

  91. Dolecek R. Endocrine changes after burn trauma. A review. Keio J. Med. 38: 262, 1989.

    CAS  Google Scholar 

  92. Naito Y., Fukata J., Tamai S., Seo N., Nakai Y., Mori K., Imura H. Biphasic changes in hypothalamo-pituitary-adrenal function during the early recovery period after major abdominal surgery. J. Clin. Endocrinol. Metab. 73: 111, 1991.

    PubMed  CAS  Google Scholar 

  93. Ayala A., Wang P., Ba Z.F., Perrin M.M., Ertel W., Chaudry I.H. Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage. Am. J. Physiol. 260: R167, 1991.

    PubMed  CAS  Google Scholar 

  94. Hall G.M., Desborough J.P. Interleukin-6 and the metabolic response to surgery Br. J. Anaesth. 69: 337, 1992.

    CAS  Google Scholar 

  95. Cruickshank A.M., Fraser W.D., Burns H.J.G., Van Damme J., Shenkin A. Response of serum interleukin-6 in patients undergoing elective surgery of varying severity. Clin. Sci 79: 161, 1990.

    PubMed  CAS  Google Scholar 

  96. Shenkin A., Fraser W.D., Series J., Winstanley E.P., McCartney A.C., Burns H.J.G., Van Damme J. The serum interleukin 6 response to elective surgery. Lymphokine Res. 8: 123, 1989.

    PubMed  CAS  Google Scholar 

  97. Pullicino E.A., Carli F., Poole S., Rafferty B., Malik S.TA. EIia M. The relationship between the circulating concentration of interleukin 6 (IL-6), tumor necrosis factor (TNF) and the acute phase response to elective surgery and accidental injury. Lymphokine Res. 9: 231, 1990.

    CAS  Google Scholar 

  98. Baigrie R.J., Lamont P.M., Kwiatkowski D., Dallman M.J., Morris P.J. Systemic cytokine response after major surgery. Brit. J. Surg. 79: 757, 1992.

    PubMed  CAS  Google Scholar 

  99. Joris J., Cigarini I., Legrand M., Jacquet N., De Groote D., Franchimont P., Lamy M. Metabolic and respiratory changes after cholecystectomy performed via laparotomy or laparoscopy. Brit. J. Anaesth. 69: 341, 1992.

    PubMed  CAS  Google Scholar 

  100. Moore C.M., Desborough J.P., Burrin J.M., Hall G.M. IL-6 and the pituitary hormone response to surgery J. Endocrinol. 132 (suppl): 207, 1992.

    Google Scholar 

  101. Guo Y., Dickerson C., Chrest F.J., Adler W.H., Munster A.M., Winchurch R.A. Increased levels of circulating interleukin 6 in burn patients. Clin. Immunol. Immunopathol. 54: 361, 1990.

    PubMed  CAS  Google Scholar 

  102. Nijstem M.W., Hack C.E., Helle M., ten Duis H.J., Klasen H.J., Aarden L.A. Interleukin-6 and its relation to the hormonal response and clinical parameters in burn patients. Surgery 109: 761, 1991.

    Google Scholar 

  103. Cannon J.G., Friedberg J.S., Gelfand J.A., Tompkins R.G., Burke J.F., Dinarello C.A. Circulating interleukin-1ß and tumor necrosis factorα concentrations after burn injury in humans. Crit. Care Med. 20: 1414, 1992.

    PubMed  CAS  Google Scholar 

  104. Wood J.J., Rodrick M.L., Omahony J.B., Palder S.B., Saporoschetz I., D’eon P., Mannick J.A. Inadequate interleukin 2 production. A fundamental immunological deficiency in patients with major burns. Ann. Surg. 200: 311, 1984.

    CAS  Google Scholar 

  105. Abraham E., Regan R.F. The effects of hemorrhage and trauma on interleukin 2 production. Arch. Surg. 120: 1341, 1985.

    PubMed  CAS  Google Scholar 

  106. Norman S., Besedovsky H., Schardt M., del Rey A. Hormonal changes following tumor transplantation: factors increasing corticosterone and the relationship of cortieosterone to tumor induced anti-inflammation. Int. J. Cancer 42: 850, 1988.

    Google Scholar 

  107. Khairallah M., Spach C., Maitre F., Motta R. Endocrine involvement in minor (non-H-2) graft versus host reaction in mice: dissociated effect on corticosterone and aldosterone plasma levels. Endocrinology 123: 1949, 1988.

    PubMed  CAS  Google Scholar 

  108. Neeck G., Federlin K., Graef V., Rusch D., Schmidt K.L. Adrenal secretion of Cortisol in patients with rheumatoid arthritis. J. Rheumatol. 17: 24, 1990.

    PubMed  CAS  Google Scholar 

  109. Sunder-Plassmann G., Stockenhuber F., Ballke P. Serum interleukin-2 activity in renal graft recipients. Transplant. Proc. 20: 387, 1988.

    PubMed  CAS  Google Scholar 

  110. Dittmer R., Harfmann P., Tenochert W., Arndt R., Busch B. Monitoring of renal transplant patient with interleukin-2 and interleukin-2 receptor enzyme immunoassay and interleukin-2 receptor immunocytology. Transplant. Proc. 22: 2284, 1990.

    PubMed  CAS  Google Scholar 

  111. Hamilton G., Prettenhofer M. Zommer A., Hofbauer H., Gotzinger P., Grant F.X., Fugger R. Intraoperative course and prognostic significance of endotoxin, tumor necrosis factor-alpha and interleukin-6 in liver transplantation recipients. Immunobiol. 182: 425, 1991.

    CAS  Google Scholar 

  112. Balkwill F., Burke F., Talbot D. Evidence for tumour necrosis factor/cachectin production in cancer. Lancet ii: 1229, 1987.

    Google Scholar 

  113. Tabibzadeh S.S., Poubouridis D., May L.T., Sehgal P.B. Interleukin-6 immunoreactivity in human tumors. Am. J. Pathol. 135: 427, 1989.

    PubMed Central  PubMed  CAS  Google Scholar 

  114. Socher S.H., Martinez D., Craig J.B., Kuhn J.G., Oliff A. Tumor necrosis factor not detectable in patients with clinical cancer cachexia. J. Natl. Cancer Inst. 80: 595, 1988

    PubMed  CAS  Google Scholar 

  115. Kanayama Y., Kim T., Inariba H., Negoro N., Okamura M., Takeda T., Inoue T. Possible involvement of interferon alfa in the pathogenesis of fever in systemic lupus erythematosus. Ann. Rheum. Dis. 48: 861, 1989.

    PubMed Central  PubMed  CAS  Google Scholar 

  116. Janadi M., Bella S., Dalaan A., Raziussin S. Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases. J. Clin. Immunol. 13: 58, 1993.

    Google Scholar 

  117. Grau G.E., Roux-Lombard P., Gysier C., Lambert C., Lambert P.H., Dayer J.M. Serum cytokine changes in systemic vasculitis. Immunology 68: 196, 1989.

    PubMed Central  PubMed  CAS  Google Scholar 

  118. Eastagate J.A., Symons J.A., Wood N.C., Grinlinton F.M., di Giovine F.S., Duff G.W. Correlation of plasma IL-1 levels with disease activity in rheumatoid arthritis. Lancet ii: 706, 1988.

    Google Scholar 

  119. Davis V.A., Frauci G.M., Rathjen D.A., Laurent R.M., Brooks P.M. Circulatory cytokine levels in patients with rheumotoid arthritis: results of a double blind trial with sulphasalazine. Ann. Rheum. Dis. 51: 946, 1992.

    Google Scholar 

  120. Brandenberger G., Follenius M. Influence of timing and intensity of muscular exercise on temporal pattern of plasma Cortisol levels. J. Clin. Endocrinol. Metab. 40: 845, 1975.

    PubMed  CAS  Google Scholar 

  121. Lugar A., Deuster P.A., Kyle S.B., Gallucci W.T., Montgomery L.C., Gold P.W., Loriaux D.L., Chrousos G.P. Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptation to physical training. N.Engl. J. Med. 316: 1309, 1987.

    Google Scholar 

  122. Cannon J.G., Kluger M.J. Endogenous pyrogen activity in human plasma after exercise. Science 220: 617, 1983.

    PubMed  CAS  Google Scholar 

  123. Cannon J.G., Meydani S.N., Fielding R.A., Fiatarone M.A., Meydani M., Farhangmehr M., Orencole S.F., Blumberg J.B., Evans W.J. Acute phase response in exercise. II Associations between vitamin E, cytokines and muscle proteolysis. Am. J. Physiol. 269: R1235, 1990.

    Google Scholar 

  124. Espersen G.T., Elbaek A., Ernst E., Toft E., Kaalung S., Jersild C., Grunnet N. Effect of physical exercise on cytokines and lymphocyte subpopulations in human peripheral bloods. Acta Pathol. Microbial. Immunol. Scand. 98: 395, 1990.

    CAS  Google Scholar 

  125. LeMay L.G., Vander A.J., Kluger M.J. The effects of psychological stress on plasma interleukin-6 activity in rats. Physiol. Behav. 47: 957, 1990

    PubMed  CAS  Google Scholar 

  126. May J.T., Viguet H., Kenney J.S., Ida N., Allison A.C., Sehgal P.B. High levels of “complexed” interleukin-6 in human blood. J. Biol. Chem. 267: 19698, 1992.

    PubMed  CAS  Google Scholar 

  127. Hishinuma I., Nagakawa J., Hirota K., Miyamoto K., Tsukidate K., Yamanaka T., LeMay L.G., Vander A.J., Kluger M.J. The effects of psychological stress on plasma interleukin-6 activity in rats. Physiol. Behav. 47: 957, 1990

    Google Scholar 

  128. Perlstein R.S., Mougey E.H., Jackson W.E., Neta R. Interleukin 1 and interleukin 6 act synergistically to stimulate the release of adrenocorticotropic hormone in vivo. Lymphokine Cytokine Res. 10: 141, 1991

    PubMed  CAS  Google Scholar 

  129. Dinarello C.A., Cannon J.G., Wolff S.M., Bernheim H.A., Beutler B., Cerami A., Figari I.S., Palladino M.A., O’Connor J.V. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J. Exp. Med. 163: 1433, 1986.

    PubMed  CAS  Google Scholar 

  130. Fong Y., Tracey K.J., Moldawer L.L., Hesse D.G., Manogue K.B., Kenney J.S., Lee AT., Kuo G.C., Allison A.C., Lowry S.F., Cerami A. Antibodies to cachectin/tumor necrosis factor reduce interleukin 6 appearance during lethal bacteremia. J. Exp. Med. 170: 1627, 1989.

    PubMed  CAS  Google Scholar 

  131. Schindler R., Mancilla J., Endres S., Ghorbani R., Clark S.C., Dinarello C.A. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 75: 40, 1990.

    PubMed  CAS  Google Scholar 

  132. Rivier C., Chizzonite R., Vale W. In the mouse, the activation of the hypothalamic-pituitary-adrenal axis by a lipopolysaccharide (endotoxin) is mediated through interleukin-1. Endocrinology 125: 2800, 1989.

    PubMed  CAS  Google Scholar 

  133. Mugridge K.G., Perretti M., Ghiara P., Parente L. α-melanocyte-stimulating hormone reduces interleukin-1ß effects on rat stomach preparations possibly through interference with a type I receptor. Eur. J. Pharmacol. 197: 151, 1991.

    PubMed  CAS  Google Scholar 

  134. Robertson B., Dostal K., Daynes R.A. Neuropeptide regulation of inflammatory and immunologic response. The capacity of α-melanocyte-stimulating hormone to inhibit tumor necrosis factor and IL-1-inducible biologic responses. J. Immunol. 140: 4300, 1988.

    CAS  Google Scholar 

  135. Martin L.W., Catania A., Hiltz M.E., Lipton J.M. Neuropeptide α-MSH antagonizes IL-6 and TNF-in-duced fever. Peptides 12: 297, 1991.

    PubMed  CAS  Google Scholar 

  136. Hiltz M.E., Catania A., Lipton J.M. α-MSH peptides inhibit acute inflammation induced in mice by rlL-1ß, rlL-6, rTNF-α and endogenous pyrogen but that caused by LTB4, PAF and rlL-8. Cytokine 4: 320, 1992.

    PubMed  CAS  Google Scholar 

  137. Schalts E., Feng Y.J., Ferin M., Wardlaw S.L α-melanocyte-stimulating hormone antagonizes the neuroendocrine effects of corticotropin-releasing factor and interleukin-1 α in the primate. Endocrinology 131: 132, 1992.

    Google Scholar 

  138. Perlstein R.S., Whitnall M.H., Abrams F.S., Mougey E.H., Neta R. Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo. Endocrinology 132: 946, 1993.

    PubMed  CAS  Google Scholar 

  139. Beutler B., Milsark I.W., Cerami A. Passive immunization against cachectin/tumor necrosis factor protects mice from the lethal effects of endotoxin. Science 229: 869, 1985.

    PubMed  CAS  Google Scholar 

  140. Tracy K.J., Fong Y., Hesse D.G., Manogue K.R., Lee A.T., Kuo G.C., Lowry S.F., Cerami A. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteremia. Nature 330: 662, 1987.

    Google Scholar 

  141. Dunn A.J. The role of interleukin-1 and tumor necrosis factor α in the neurochemical and neuroendocrine responses to endotoxin. Brain. Res. Bull. 29: 807, 1992.

    PubMed  CAS  Google Scholar 

  142. Le Contel C., Parant F., Parant M. Indirect and selective down-regulation of serum tumor necrosis factor-α release by interleukin-1, ß. Immunobiol. 186: 199, 1992.

    Google Scholar 

  143. Neta R., Perlstein R., Vogel S.N., Ledney G.D., Abrams J. Role of interleukin 6 (IL-6) in protection from lethal irradiation and in endocrine responses to IL-1 and tumor necrosis factor. J. Exp. Med. 175: 689, 1992

    PubMed  CAS  Google Scholar 

  144. Gosselin J., Flamand L., D’Addario M., Hiscott J., Menezes J. Infection of peripheral blood mononuclear cells by herpes simplex and Epstein-Barr viruses. Differential induction of interleukin-6 and tumor necrosis factor-α. J. Clin. Invest. 89: 1849, 1992.

    CAS  Google Scholar 

  145. Leopardi R., Vainonpaa R., Hurme M., Siljander P., Salmi A.A. Measles virus infection enhances IL-1ß but reduces tumor necrosis factor-α expression in human monocytes. J. Immunol. 149: 2397, 1992.

    PubMed  CAS  Google Scholar 

  146. Numerof R.P., Aronson F.R., Mier J.W. IL-2 stimulates the production of IL-1 alfa and IL-1 beta by human peripheral blood mononuclear cells. J. Immunol. 141: 4250, 1988

    PubMed  CAS  Google Scholar 

  147. Handa K., Suzuki R., Matsui H., Shimizu Y., Kumagai K. Natural killer (NK) cells as a responder to interleukin-2(IL 2): IL-2 induced interferon gamma production. J. Immunol. 130: 988, 1983.

    PubMed  CAS  Google Scholar 

  148. Nedwin G.E., Sveersky L.P., Bringman T.S., Palladino M.A., Gueddel D.V. Effects of interleukin-2, interferon gamma and mitogens on the production of tumor necrosis factor alpha and beta. J. Immunol. 135: 2492, 1985.

    PubMed  CAS  Google Scholar 

  149. Saez J.M., Dazord A., Gallet D. ACTH and prostaglandin receptors in human adrenocortical tumors. J. Clin. Invest. 56: 536, 1975.

    PubMed Central  PubMed  CAS  Google Scholar 

  150. Aikawa T., Hirose T., Matsumoto I., Morikawa T., Shimada T., Mine Y., Tsujimoto Y., Tsuji Y. Effect of platelet-activating factor on Cortisol and corticosterone secretion by perfused dog adrenal. Lipids 26: 1108, 1991.

    PubMed  CAS  Google Scholar 

  151. Breslow M.J., Tobin J.R., Bredt D.S., Ferris C.D., Snyder S.H., Traystman R.J. Nitric oxide as a regulator of adrenal blood flow. Am. J. Physiol. 264: H464, 1993.

    PubMed  CAS  Google Scholar 

  152. Hinson J.P., Vinson G.P., Whitehouse B.J. The relationship between perfusion medium flow rate and steroid secretion in isolated perfused rat adrenal gland in situ. J. Endocrinol. 111: 391, 1986.

    PubMed  CAS  Google Scholar 

  153. Suzuki S., Oh C., Nakano K. Pituitary-dependent and -independent secretion of CS caused by bacterial endotoxin in rats. Am. J. Physiol. 250: E470, 1986.

    PubMed  CAS  Google Scholar 

  154. Smith E.M., Meyer W.J., Blalock J.E. Virus-induced corticosterone in hypophysectomized mice: a possible lymphoid-adrenal axis. Science 218: 1311, 1982.

    PubMed  CAS  Google Scholar 

  155. Smith E.M., Galin S., LeBoeuf R.D., Coppenhaver D.H., Harbour D.V., Blalock J.E. Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide. Proc. Natl. Acad. Sci. USA 87: 1057, 1990.

    PubMed Central  PubMed  CAS  Google Scholar 

  156. Clarke B.L., Gebhardt B.M., Blalock J.E. Mitogen-stimulated lymphocytes release biologically active corticotropin. Endocrinology 132: 983, 1993.

    PubMed  CAS  Google Scholar 

  157. Dunn A.J., Powell M.L., Gaskin J.M. Virus-induced increase in plasma corticosterone: a technical comments on Smith, Meyer, and Blalock. Science 238: 1423, 1987.

    PubMed  CAS  Google Scholar 

  158. Olsen N.J., Nicholson W.E., DeBold C.R., Orth D.N. Lymphocyte-derived adrenocorticotropin is insufficient to stimulate adrenal steroidogenesis in hypophysectomized rats. Endocrinology 130: 2113, 1992.

    PubMed  CAS  Google Scholar 

  159. Fontana A., Weber E., Dayer J.M. Synthesis of interleukin-1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction? J. Immunol. 133: 1696, 1984.

    CAS  Google Scholar 

  160. Yamamori T., Sarai A. Coevolutuion of cytokine receptor families in the immune and nervous system. Neurosci. Res. 15: 151, 1992.

    PubMed  CAS  Google Scholar 

  161. Benveniste E.N. Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action. Am. J. Physiol. 263: C1, 1992.

    PubMed  CAS  Google Scholar 

  162. Nistico G., De Sarro G. Is interleukin 2 a neuromodulator in the brain? Trend Neurosci. 14: 146, 1991.

    PubMed  CAS  Google Scholar 

  163. Ebisui O., Fukata J., Tominaga T., Murakami N., Kobayashi H., Segawa H., Muro S., Naito Y., Nakai Y., Masui Y., Nishida T., Imura H. Roles of interleukin-1α and -1ß in endotoxin-induced suppression of plasma gonadotropin levels in rats. Endocrinology 130: 3307, 1992.

    PubMed  CAS  Google Scholar 

  164. Katsuura G., Gottschall P.E., Dahl R.R., Arimura A. Adrenocorticotropin release induced by intracerebroventricular injection of recombinant interleukin-1 in rats: possible involvement of prostaglandin. Endocrinology 122: 1773, 1988.

    PubMed  CAS  Google Scholar 

  165. Kakucska I., Qi Y., Clark B.D., Lechan R.M. Endotoxin-induced corticotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1. Endocrinology 133: 815, 1993.

    PubMed  CAS  Google Scholar 

  166. Arzt E., Stelzer G., Renner U., Lange M., Muller O.A., Stalla G.K. Interleukin-2 and interleukin-2 receptor expression in human corticotropic adenoma and murine pituitary cell cultures. J. Clin. Invest. 90: 1944, 1992.

    PubMed Central  PubMed  CAS  Google Scholar 

  167. Bristulf J., Simoncsits A., Bartfai T. Characterization of a neural interleukin-1 receptor and the corresponding mRNA in the mouse anterior pituitary cell line AtT-20. Neurosci. Lett. 128: 173, 1991.

    PubMed  CAS  Google Scholar 

  168. Ohmichi M., Hirota K., Koike K., Kurachi H., Ohtsuka S., Matsuzaki N., Yamaguchi M., Miyake A., Tanizawa O. Binding sites for interleukin-6 in the anterior pituitary gland. Neuroendocrinology 55: 199, 1992.

    PubMed  CAS  Google Scholar 

  169. Valkeniers B., D’Haens G., Smets G., Vergani P., Vanhaelst L., Hooghe-Peters E.L. Expression of IL-6 mRNA in corticotroph cell adenomas. J. Endocrinol. Invest. (Suppl. 1) 14: 31, 1991 (Abstr.).

    Google Scholar 

  170. Vankelecom H., Carmeliet P., Van Damme J., Billiau A., Denef C. Production of interleukin-6 by folliculo-stellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system. Neuroendocrinology 49: 102, 1989.

    PubMed  CAS  Google Scholar 

  171. Fukata J., Naitoh Y., Usui T., Tominaga T., Murakami N., Nakai Y., Imura H. Effects of interleukins on hypothalamo-pituitaryadrenal axis. In: Hatase O., Wang J.H. eds., Bioinformaties. Elsevier Science Publishers BV, 425, 1989.

  172. Smith L.R., Brown S.L., Blalock J.E. Interleukin-2 induction of ACTH secretion: presence of an interleukin-2 receptor α-chain-like molecule on pituitary cells. J. Neuroimmunol. 21: 249, 1989.

    PubMed  CAS  Google Scholar 

  173. Karanth S., McCann S.M. Anterior pituitary hormone control by interleukin 2. Proc. Natl. Acad. Sci USA 99: 2961, 1991.

    Google Scholar 

  174. Koenig J.I., Snow K., Clark B.D., Toni R., Cannon J.G., Shaw A.R., Dinarello C.A., Reichlin S., Lee S.L., Lechan R.M. Intrinsic pituitary interleukin-1 is induced by baeterial lipopolysaccharide. Endocrinology 126: 3053, 1990.

    PubMed  CAS  Google Scholar 

  175. Spangelo B.L., Judd A.M., MacLeod R.M., Goodman D.W., Isackson P.C. Endotoxin-induced release of interleukin-6 from rat medial basal hypothalami. Endocrinology 127: 1779, 1990.

    PubMed  CAS  Google Scholar 

  176. Murakami N., Fukata J., Tsukada T., Nakai Y., Imura H. Endotoxin-induced changes in hormone and interleukin synthesis in the hypothalamie-pituitary-adrenal axis. Abstr. of 9th Intern. Congr. of Endocrinol. P-01, 31, 045, 1992 (Abst).

  177. Hanley N., Williams B.C., Nieol M., Bird I.M., Walker S.W. Interleukin-1ß stimulates growth of adrenocortical cells in primary culture. J. Mol. Endocrinol. 8: 131, 1992.

    PubMed  CAS  Google Scholar 

  178. Achultberg M., Anderson C., Unden A., Troye-Blowberg M., Svenson S.B., Bartfai T. Interleukin-1 in adrenal chromaffin cells. Neuroscience 30: 805, 1989.

    Google Scholar 

  179. Judd A.M., Spangelo B.L., MacLeod R.M. Rat adrenal zona glomerulosa cells produce interleukin-6. Prog. NeuroEndocrin. Immunol. 3: 282, 1990.

    Google Scholar 

  180. Schobitz B., van den Dobbelsteen M., Holsboer F., Sutanto W., de Kloet E.R. Regulation of interleukin-6 gene expression in the rat. Endocrinology 132: 1569, 1993.

    PubMed  CAS  Google Scholar 

  181. Cavaillon J.M., Munoz C., Fitting C., Misset B., Carlet J. Circulating cytokines: The tip of the iceberg? Circ. Shock 38: 145, 1992.

    PubMed  CAS  Google Scholar 

  182. Tracy K.J., Morgello S., Koplin B., Fahey T.J. III, Fox J., Aledo A., Manogue K.R., Cerami A. Metabolic effects of cachectin/tumor necrosis factor are modified by site of production: Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominately acute anorexia. J. Clin. Invest. 86: 2014, 1990.

    Google Scholar 

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  1. Endocrinology Service, Shizuoka City Hospital, Ohtemachi 10-93, Shizuoka, 420, Japan

    Junichi Fukata M.D. & H. Imura

  2. Department of Medicine, Kyoto University, Kyoto, Japan

    K. Nakao

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Fukata, J., Imura, H. & Nakao, K. Cytokines as mediators in the regulation of the hypothalamic-pituitary-adrenocortical function. J Endocrinol Invest 17, 141–155 (1994). https://doi.org/10.1007/BF03347705

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