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The effect of dexamethasone on gastric mucosal changes following sialoadenectomy in rat

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Abstract

In this study, dexamethasone-induced gastric lesions were studied in rats that had undergone sialoadenectomy. The ultrastructural changes developed during the study were detected by electron microscopically, while blood serum and stomach epidermal growth factor (EGF) concentrations were measured by RIA. The result of the study showed that gastric lesions were correlated with gastric mucus secretion and both serum and mucosa EGF levels. After the administration of dexamethasone, it was found that sialoadenectomy significantly (p<0.01) raised the incidence of stomach lesions (p<0.01), and a significant increase in mucus secretion was also found. Additionally, the serum and gastric mucosal EGF levels fell after sialoadenectomy when compared to normal rats. The most important gastric mucosal changes were observed in rats treated with dexamethasone and those both sialoadenectomised and treated with dexamethasone.

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Authors and Affiliations

  1. Department of Internal Medicine, Afyon Kocatepe University Faculty of Veterinary Medicine, Ahmet Necdet Sezer kampusü, TR-03200, Afyon, Turkey

    B. Elitok

  2. Agriculture Researching Instutute, Animal Health Division, Afyon

    Ö. M. Elitok

  3. Department of Histology, University of Dicle, Diyarbakir, Turkey

    M. A. Ketani

  4. Department of Physiology, Faculty of Veterinary Medicine, University of Dicle, Diyarbakir, Turkey

    D. Kurt & Z. Kanay

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  1. B. Elitok
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  2. Ö. M. Elitok
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  4. D. Kurt
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  5. Z. Kanay
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Correspondence to B. Elitok.

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Elitok, B., Elitok, Ö.M., Ketani, M.A. et al. The effect of dexamethasone on gastric mucosal changes following sialoadenectomy in rat. J Endocrinol Invest 28, 700–703 (2005). https://doi.org/10.1007/BF03347552

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  • DOI: https://doi.org/10.1007/BF03347552

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