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Oncocytic mania: A review of oncocytic lesions throughout the body

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Abstract

Oncocytic lesions are characterized pathologically by an abundance of oncocytes, that is by enlarged, eosinophilic, and finely granular cells enriched in mitochondria. They can arise in numerous organs and tissues, often in endocrine glands, and have been associated with hyperplasia, autoimmunity, and neoplasia. The causes and mechanisms that transform a normal cell into an oncocyte remain to be elucidated. Aim of this article is to review the most common oncocytic lesions, highlighting their key pathological features and clinical significance.

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References

  1. Schaffer TJ: Beitrage zur Histologie Menischlicher Organe. IV. Zunge. V. Mundhohle-Schlundkopf. VI. Oesophagus. VII. Cardia. Sitzungsber. d. Kais. Akad. d. Wissensch., Math. naturwiss. Classe, Abth. 111.Wien. 106: 353–7, 1897.

    Google Scholar 

  2. Askanazy M. Pathologisch-anatomische Beiträge zur Kenntniss des Morbus Basedowii, insbesondere über die dabei auftretende Muskelerkrankung. Dtsch Arch Klin Med 1898, 61: 118–86.

    Google Scholar 

  3. Welsh DA. Concerning the parathyroid gland: A critical anatomical and experimental study. J Anat Physiol 1898, 32: 292–307 and 380–401.

    PubMed  CAS  PubMed Central  Google Scholar 

  4. Hamperl H. Beiträge zur normalen und pathologischen Histologie menschlicher Speicheldrüsen. Z Mikrosk Anat Forsch 1931, 27: 1–55.

    Google Scholar 

  5. Jaffe R. Adenolymphoma (oncocytoma) of the parotid gland. Am J Cancer 1932, 16: 1415–23.

    Google Scholar 

  6. Chang A, Harawi SJ. Oncocytes, oncocytosis, and oncocytic tumors. Pathol Annu 1992, 27: 263–304.

    PubMed  Google Scholar 

  7. Biggs SL, Font RL. Oncocytic lesions of the caruncle and other ocular adnexa. Arch Ophthalmol 1977, 95: 474–8.

    PubMed  CAS  Google Scholar 

  8. Hartwick RW, Batsakis JG. Non-Warthin’s tumor oncocytic lesions. Ann Otol Rhinol Laryngol 1990, 99: 674–7.

    PubMed  CAS  Google Scholar 

  9. Park DH, Park YK, Oh JI, et al. Oncocytic paraganglioma of the cauda equina in a child. Case report and review of the literature. Pediatr Neurosurg 2002, 36: 260–5.

    Google Scholar 

  10. Sav A, Scheithauer BW, Mazzola CA, Ketterling SR, Thompson SJ, Reilly MH. Oncocytic choroid plexus carcinoma: case report. Clin Neuropathol 2010, 29: 14–20.

    PubMed  CAS  Google Scholar 

  11. Liszka L, Pajak J, Zielinska-Pajak E, et al. Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature. J Hepatobiliary Pancreat Sci 2010, 17: 246–61.

    PubMed  Google Scholar 

  12. Romis L, Cindolo L, Patard JJ, et al. Frequency, clinical presentation and evolution of renal oncocytomas: multicentric experience from a European database. Eur Urol 2004, 45: 53–7.

    PubMed  Google Scholar 

  13. Tanaka M, Fukushima N, Noda N, Shibahara J, Kokudo N, Fukayama M. Intraductal oncocytic papillary neoplasm of the bile duct: clinicopathologic and immunohistochemical characteristics of 6 cases. Hum Pathol 2009, 40: 1543–52.

    PubMed  CAS  Google Scholar 

  14. Crotty TB, Farrow GM, Lieber MM. Chromophobe cell renal carcinoma: clinicopathological features of 50 cases. J Urol 1995, 154: 964–7.

    PubMed  CAS  Google Scholar 

  15. Fukushima T, Nagashima Y, Nakatani Y, et al. Chromophobe renal cell carcinoma: a report of two cases. Pathol Int 1994, 44: 401–6.

    PubMed  CAS  Google Scholar 

  16. Griffiths AP, Dekker P. Oncocytic metaplasia of the nasopharynx or extra-parotid Warthin’s tumour? J Clin Pathol 1991,44: 1030–2.

    PubMed  CAS  PubMed Central  Google Scholar 

  17. Sakaki M, Shek TW, Hirokawa M, et al. Melanotic oncocytic metaplasia of the nasopharynx: a report of seven cases and review of the literature. Virchows Arch 2004, 444: 345–9.

    PubMed  Google Scholar 

  18. Eisen D. Riedel’s struma. Am J Med Sci 1936, 192: 673–88.

    Google Scholar 

  19. Demasi AP, Furuse C, Altemani A, Junqueira JL, Oliveira PR, Araujo VC. Peroxiredoxin I is overexpressed in oncocytic lesions of salivary glands. J Oral Pathol Med 2009, 38: 514–7.

    PubMed  CAS  Google Scholar 

  20. Kuwahara H, Shimazaki M, Kadoya Y, et al. Immunohistochemical localization of two types of carbonic anhydrase isozymes in oncocytoma and oncocytic epithelial cells. Osaka City Med J 1989, 35: 121–36.

    PubMed  CAS  Google Scholar 

  21. Udaka T, Shiomori T, Nagatani G, et al. Oncocytic schneiderian papilloma confined to the sphenoid sinus detected by FDG-PET. Rhinology 2007, 45: 89–92.

    PubMed  Google Scholar 

  22. Varma VA, Cerjan CM, Abbott KL, Hunter SB. Non-isotopic in situ hybridization method for mitochondria in oncocytes. J Histochem Cytochem 1994, 42: 273–6.

    PubMed  CAS  Google Scholar 

  23. Roncaroli F, Scheithauer BW. Papillary tumor of the pineal region and spindle cell oncocytoma of the pituitary: new tumor entities in the 2007 WHO Classification. Brain Pathol 2007, 17: 314–8.

    PubMed  Google Scholar 

  24. Kurek R, Von Knobloch R, Feek U, Heidenreich A, Hofmann R. Local recurrence of an oncocytic adrenocortical carcinoma with ovary metastasis. J Urol 2001, 166: 985.

    PubMed  CAS  Google Scholar 

  25. Mahmoud NA. Malignant oncocytoma of the nasal cavity. J Laryngol Otol 1979, 93: 729–34.

    PubMed  CAS  Google Scholar 

  26. Gallina P, Buccoliero AM, Mariotti F, Mennonna P, Di Lorenzo N. Oncocytic meningiomas: Cases with benign histopathological features and a favorable clinical course. J Neurosurg 2006, 105: 736–8.

    PubMed  Google Scholar 

  27. Roncaroli F, Riccioni L, Cerati M, et al. Oncocytic meningioma. Am J Surg Pathol 1997, 21: 375–82.

    PubMed  CAS  Google Scholar 

  28. Tsunoda S, Sakaki T, Kubota T, et al. Anaplastic astrocytoma of an oncocytic type occurring in the cerebellar vermis in Pierre Robin syndrome — case report. Neurol Med Chir (Tokyo) 1992, 32: 911–4.

    CAS  Google Scholar 

  29. Perry A, Louis DN, Scheithauer BW, Budka H, von Deimling A. Meningioma. In: Louis DN, Ohgaki H, Wiestler OD, Cavanee WK eds. WHO classification of tumours of the central nervous system. Lyon: International Agency for Research on Cancer. 2007, 164–72.

    Google Scholar 

  30. Giangaspero F, Cenacchi G. Oncocytic and granular cell neoplasms of the central nervous system and pituitary gland. Semin Diagn Pathol 1999, 16: 91–7.

    PubMed  CAS  Google Scholar 

  31. Stefanko SZ, Vuzevski VD. Oncocytic variant of choroid plexus papilloma. Acta Neuropathol 1985, 66: 160–2.

    PubMed  CAS  Google Scholar 

  32. Tanji K, Schon EA, DiMauro S, Bonilla E. Kearns-sayre syndrome: oncocytic transformation of choroid plexus epithelium. J Neurol Sci 2000, 178: 29–36.

    PubMed  CAS  Google Scholar 

  33. Hayostek CJ, Shaw EG, Scheithauer B, et al. Astrocytomas of the cerebellum. A comparative clinicopathologic study of pilocytic and diffuse astrocytomas. Cancer 1993, 72: 856–69.

    CAS  Google Scholar 

  34. Domanski H, Ljungberg O, Andersson LO, Schele B. Oxyphil cell adenoma (oncocytoma) of the lacrimal sac. Review of the literature. Acta Ophthalmol (Copenh) 1994, 72: 393–6.

    CAS  Google Scholar 

  35. Fayet B, Bernard JA, Zachar D, et al. [Malignant nasal oncocytoma disclosed by mucocele of the lacrimal sac with hemolacrimia]. J Fr Ophtalmol 1990, 13: 153–8.

    PubMed  CAS  Google Scholar 

  36. Levin LA, Popham J, To K, Hein A, Shore J, Jakobiec FA. Mucoepidermoid carcinoma of the lacrimal gland. Report of a case with oncocytic features arising in a patient with chronic dacryops. Ophthalmology 1991, 98: 1551–5.

    CAS  Google Scholar 

  37. Rodgers IR, Jakobiec FA, Krebs W, Hornblass A, Gingold MP. Papillary oncocytoma of the eyelid. A previously undescribed tumor of apocrine gland origin. Ophthalmology 1988, 95: 1071–6.

    CAS  Google Scholar 

  38. Thaller VT, Collin JR, McCartney AC. Oncocytoma of the eyelid: a case report. Br J Ophthalmol 1987, 71: 753–6.

    PubMed  CAS  PubMed Central  Google Scholar 

  39. Gonnering RS, Sonneland PR. Oncocytic carcinoma of the plica semilunaris with orbital extension. Ophthalmic Surg 1987, 18: 604–7.

    PubMed  CAS  Google Scholar 

  40. Lamping KA, Albert DM, Ni C, Fournier G. Oxyphil cell adenomas. Three case reports. Arch Ophthalmol 1984, 102: 263–5.

    CAS  Google Scholar 

  41. Perlman JI, Specht CS, McLean IW, Wolfe SA. Oncocytic adenocarcinoma of the lacrimal sac: report of a case with paranasal sinus and orbital extension. Ophthalmic Surg 1995, 26: 377–9.

    PubMed  CAS  Google Scholar 

  42. Barnes L, Bedetti C. Oncocytic Schneiderian papilloma: a reappraisal of cylindrical cell papilloma of the sinonasal tract. Hum Pathol 1984, 15: 344–51.

    PubMed  CAS  Google Scholar 

  43. Lombardi D, Piccioni M, Farina D, Morassi ML, Nicolai P. Oncocytic carcinoma of the maxillary sinus: a rare neoplasm. Eur Arch Otorhinolaryngol 2006, 263: 528–31.

    PubMed  Google Scholar 

  44. Kovacs K, Horvath E, Ryan N, Ezrin C. Null cell adenoma of the human pituitary. Virchows Arch A Pathol Anat Histol 1980,387: 165–74.

    PubMed  CAS  Google Scholar 

  45. Weber T, Saeger W, Ludecke DK. Light microscopical morphometry, immunocytochemistry, and clinical correlations of pituitary adenomas at various stages of oncocytic transformation. Acta Endocrinol (Copenh) 1987, 116: 489–96.

    CAS  Google Scholar 

  46. Landolt AM, Oswald UW. Histology and ultrastructure of an oncocytic adenoma of the human pituitary. Cancer 1973, 31: 1099–105.

    PubMed  CAS  Google Scholar 

  47. Silbergeld DL, Mayberg MR, Berger MS, Ali-Osman F, Kelly WA, Shaw CM. Pituitary oncocytomas: clinical features, characteristics in cell culture, and treatment recommendations. J Neurooncol 1993, 16: 39–46.

    PubMed  CAS  Google Scholar 

  48. Roncaroli F, Scheithauer BW, Cenacchi G, et al. ‘Spindle cell oncocytoma’ of the adenohypophysis: a tumor of folliculostellate cells? Am J Surg Pathol 2002, 26: 1048–55.

    PubMed  Google Scholar 

  49. Kloub O, Perry A, Tu PH, Lipper M, Lopes MB. Spindle cell oncocytoma of the adenohypophysis: report of two recurrent cases. Am J Surg Pathol 2005, 29: 247–53.

    PubMed  Google Scholar 

  50. Borota OC, Scheithauer BW, Fougner SL, Hald JK, Ramm-Pettersen J, Bollerslev J. Spindle cell oncocytoma of the adenohypophysis: report of a case with marked cellular atypia and recurrence despite adjuvant treatment. Clin Neuropathol 2009, 28: 91–5.

    PubMed  Google Scholar 

  51. Eversole LR, Sabes WR. Minor salivary gland duct changes due to obstruction. Arch Otolaryngol 1971, 94: 19–24.

    PubMed  CAS  Google Scholar 

  52. Liao CT, Kuo TT. Images in pathology. Melanotic oncocytic metaplasia of the nasopharynx. Int J Surg Pathol 2005, 13: 279.

    Google Scholar 

  53. Gallo O, Bocciolini C. Warthin’s tumour associated with autoimmune diseases and tobacco use. Acta Otolaryngol 1997, 117: 623–7.

    PubMed  CAS  Google Scholar 

  54. Wakely PE, Jr. Oncocytic and oncocyte-like lesions of the head and neck. Ann Diagn Pathol 2008, 12: 222–30.

    PubMed  Google Scholar 

  55. Kotwall CA. Smoking as an etiologic factor in the development of Warthin’s tumor of the parotid gland. Am J Surg 1992, 164: 646–7.

    PubMed  CAS  Google Scholar 

  56. Eveson JW, Cawson RA. Infarcted (‘infected’) adenolymphomas. A clinicopathological study of 20 cases. Clin Otolaryngol Allied Sci 1989, 14: 205–10.

    CAS  Google Scholar 

  57. Seifert G, Bull HG, Donath K. Histologic subclassification of the cystadenolymphoma of the parotid gland. Analysis of 275 cases. Virchows Arch A Pathol Anat Histol 1980, 388: 13–38.

    CAS  Google Scholar 

  58. Bengoechea O, Sánchez F, Larrínaga B, Martínez-Peñuela JM. Oncocytic adenocarcinoma arising in Warthin’s tumor. Pathol Res Pract 1989, 185: 907–11.

    PubMed  CAS  Google Scholar 

  59. Brandwein MS, Huvos AG. Oncocytic tumors of major salivary glands. A study of 68 cases with follow-up of 44 patients. Am J Surg Pathol 1991, 15: 514–28.

    CAS  Google Scholar 

  60. Ellis GL. “Clear cell” oncocytoma of salivary gland. Hum Pathol 1988, 19: 862–7.

    PubMed  CAS  Google Scholar 

  61. Gallagher JC, Puzon BQ. Oncocytic lesions of the larynx. Ann Otol Rhinol Laryngol 1969, 78: 307–18.

    PubMed  CAS  Google Scholar 

  62. Foulsham CK 2nd, Snyder GG 3rd, Carpenter RJ 3rd. Papillary cystadenoma lymphomatosum of the larynx. Otolaryngol Head Neck Surg 1981, 89: 960–4.

    PubMed  Google Scholar 

  63. Goode RK, Corio RL. Oncocytic adenocarcinoma of salivary glands. Oral Surg Oral Med Oral Pathol 1988, 65: 61–6.

    PubMed  CAS  Google Scholar 

  64. Nakada M, Nishizaki K, Akagi H, Masuda Y, Yoshino T. Oncocytic carcinoma of the submandibular gland: a case report and literature review. J Oral Pathol Med 1998, 27: 225–8.

    PubMed  CAS  Google Scholar 

  65. Caturegli P, Ruggere C. Karl Hürthle! Now, who was he? Thyroid 2005, 15: 121–3.

    PubMed  Google Scholar 

  66. Hashimoto H. Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa). Arch Klin Chir 1912, 18: 243.

    Google Scholar 

  67. Tallini G, Carcangiu ML, Rosai J. Oncocytic neoplasms of the thyroid gland. Acta Pathol Jpn 1992, 42: 305–5.

    PubMed  CAS  Google Scholar 

  68. Thompson NW, Dunn EL, Batsakis JG, Nishiyama RH. Hürthle cell lesions of the thyroid gland. Surg Gynecol Obstet 1974, 139: 555–60.

    PubMed  CAS  Google Scholar 

  69. Thomas GA, Williams D, Williams ED. The clonal origin of thyroid nodules and adenomas. Am J Pathol 1989, 134: 141–7.

    PubMed  CAS  PubMed Central  Google Scholar 

  70. Hundahl SA, Fleming ID, Fremgen AM, Menck HR. A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995 [see comments]. Cancer 1998, 83: 2638–48.

    PubMed  CAS  Google Scholar 

  71. Troncone G, Iaccarino A, Russo M, et al. Accumulation of p27(kip1) is associated with cyclin D3 overexpression in the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma. J Clin Pathol 2007, 60: 377–81.

    PubMed  CAS  PubMed Central  Google Scholar 

  72. Segev DL, Saji M, Phillips GS, et al. Polymerase chain reaction-based microsatellite polymorphism analysis of follicular and Hurthle cell neoplasms of the thyroid. J Clin Endocrinol Metab 1998, 83: 2036–42.

    PubMed  CAS  Google Scholar 

  73. French CA, Alexander EK, Cibas ES, et al. Genetic and biological subgroups of low-stage follicular thyroid cancer. Am J Pathol 2003, 162: 1053–60.

    PubMed  CAS  PubMed Central  Google Scholar 

  74. Nikiforova MN, Lynch RA, Biddinger PW, et al. RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma. J Clin Endocrinol Metab 2003, 88: 2318–26.

    PubMed  CAS  Google Scholar 

  75. Cerutti JM, Oler G, Delcelo R, et al. PVALB, a new Hürthle adenoma diagnostic marker identified through gene expression. J Clin Endocrinol Metab 2011, 96: E151–60.

    PubMed  CAS  PubMed Central  Google Scholar 

  76. Bleier BS, LiVolsi VA, Chalian AA, Gimotty PA, Botbyl JD, Weber RS. Technetium Tc 99m sestamibi sensitivity in oxyphil cell-dominant parathyroid adenomas. Arch Otolaryngol Head Neck Surg 2006, 132: 779–82.

    PubMed  Google Scholar 

  77. Wolpert HR, Vickery AL Jr, Wang CA. Functioning oxyphil cell adenomas of the parathyroid gland. A study of 15 cases. Am J Surg Pathol 1989, 13: 500–4.

    PubMed  CAS  Google Scholar 

  78. Muller-Hocker J, Schafer S, Copeland WC, Wiesner R, Seibel P. Immunohistochemical detection of human mtDNA polymerase gamma and of human mitochondrial transcription factor A in cytochrome-c-oxidase-deficient oxyphil cells of hyperfunctional parathyroids. Virchows Arch 1998, 433: 529–36.

    PubMed  CAS  Google Scholar 

  79. Bondeson L, Sandelin K, Grimelius L. Histopathological variables and DNA cytometry in parathyroid carcinoma. Am J Surg Pathol 1993, 17: 820–9.

    PubMed  CAS  Google Scholar 

  80. Erickson LA, Jin L, Papotti M, Lloyd RV. Oxyphil parathyroid carcinomas: a clinicopathologic and immunohistochemical study of 10 cases. Am J Surg Pathol 2002, 26: 344–9.

    PubMed  Google Scholar 

  81. Papadimitriou A, Neustein HB, Dimauro S, Stanton R, Bresolin N. Histiocytoid cardiomyopathy of infancy: deficiency of reducible cytochrome b in heart mitochondria. Pediatr Res 1984, 18: 1023–8.

    PubMed  CAS  Google Scholar 

  82. Malhotra V, Ferrans VJ, Virmani R. Infantile histiocytoid cardiomyopathy: three cases and literature review. Am Heart J 1994, 128: 1009–21.

    PubMed  CAS  Google Scholar 

  83. Hotarkova S, Hermanova M, Povysilova V, et al. Demonstration of MyoD1 expression in oncocytic cardiomyopathy: report of two cases and review of the literature. Pathol Res Pract 2004, 200: 59–65.

    PubMed  CAS  Google Scholar 

  84. McGregor CG, Gibson A, Caves P. Infantile cardiomyopathy with histiocytoid change in cardiac muscle cells: successful surgical intervention and prolonged survival. Am J Cardiol 1984, 53: 982–3.

    PubMed  CAS  Google Scholar 

  85. Fechner RE, Bentinck BR. Ultrastructure of bronchial oncocytoma. Cancer 1973, 31: 1451–7.

    PubMed  CAS  Google Scholar 

  86. Ritter JH, Nappi O. Oxyphilic proliferations of the respiratory tract and paranasal sinuses. Semin Diagn Pathol 1999, 16: 105–16.

    PubMed  CAS  Google Scholar 

  87. de Aquino RT, Magliari ME, Saad R Jr, et al. Bronchial oncocytoma. Sao Paulo Med J 2000, 118: 195–7.

    PubMed  Google Scholar 

  88. Cwierzyk TA, Glasberg SS, Virshup MA, Cranmer JC. Pulmonary oncocytoma. Report of a case with cytologic, histologic and electron microscopic study. Acta Cytol 1985, 29: 620–3.

    CAS  Google Scholar 

  89. Tashiro Y, Iwata Y, Nabae T, Manabe H. Pulmonary oncocytoma: report of a case in conjunction with an immunohistochemical and ultrastructural study. Pathol Int 1995, 45: 448–51.

    PubMed  CAS  Google Scholar 

  90. Damiani S, Eusebi V, Losi L, D’Adda T, Rosai J. Oncocytic carcinoma (malignant oncocytoma) of the breast. Am J Surg Pathol 1998, 22: 221–30.

    PubMed  CAS  Google Scholar 

  91. Costa MJ, Silverberg SG. Oncocytic carcinoma of the male breast. Arch Pathol Lab Med 1989, 113: 1396–9.

    PubMed  CAS  Google Scholar 

  92. Motta MP, Athanazio DA, Motta A, Studart E, Athanazio PR. Parietal cell (oncocytic) adenocarcinoma of the stomach in a female patient: superficial spreading and extensive nodal involvement. Int J Surg Pathol 2008, 16: 447–9.

    PubMed  Google Scholar 

  93. Takubo K, Honma N, Sawabe M, et al. Oncocytic adenocarcinoma of the stomach: parietal cell carcinoma. Am J Surg Pathol 2002, 26: 458–65.

    PubMed  Google Scholar 

  94. Gaffney EF. Favourable prognosis in gastric carcinoma with parietal cell differentiation. Histopathology 1987, 11: 217–8.

    PubMed  CAS  Google Scholar 

  95. Batistatou A, Doukas M, Baltogiannis G, et al. Early gastric carcinoma with oncocytic features and extensive metastases. Pathol Res Pract 2007, 203: 539–41.

    PubMed  Google Scholar 

  96. Lee RG. Villous regeneration in ulcerative colitis. Arch Pathol Lab Med 1987, 111: 276–8.

    PubMed  CAS  Google Scholar 

  97. Ambrosini-Spaltro A, Salvi F, Betts CM, et al. Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy. Virchows Arch 2006, 448: 442–8.

    PubMed  CAS  Google Scholar 

  98. Chetty R, Serra S, Kennedy E, Govender D. Oncocytic rectal adenocarcinomas. Hum Pathol 2009, 40: 478–83.

    PubMed  Google Scholar 

  99. Fukuda D, Ikematsu H, Kojima M, et al. Early oncocytic adenocarcinoma of the transverse colon. Endoscopy 2010, 42(Suppl 2): E261–2.

    PubMed  Google Scholar 

  100. Piana S, Asioli S, Foroni M. Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features. Virchows Arch 2006, 448: 228–31.

    PubMed  Google Scholar 

  101. Piscitelli D, Ingravallo G, Resta L, Fiore MG, Maiorano E. Oncocytic adenocarcinoma of the rectum with diffuse intra-luminal microcalcifications: the first reported case. Virchows Arch 2003, 443: 579–82.

    PubMed  Google Scholar 

  102. Torbenson M. Review of the clinicopathologic features of fibrolamellar carcinoma. Adv Anat Pathol 2007, 14: 217–23.

    PubMed  Google Scholar 

  103. Ross HM, Daniel HD, Vivekanandan P, et al. Fibrolamellar carcinomas are positive for CD68. Mod Pathol 2011, 24: 390–5.

    PubMed  CAS  PubMed Central  Google Scholar 

  104. Shibahara H, Tamada S, Goto M, et al. Pathologic features of mucin-producing bile duct tumors: two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neo-plasms. Am J Surg Pathol 2004, 28: 327–38.

    PubMed  Google Scholar 

  105. Nakanishi Y, Zen Y, Kondo S, Itoh T, Itatsu K, Nakanuma Y. Expression of cell cycle-related molecules in biliary premalignant lesions: biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm. Hum Pathol 2008, 39: 1153–61.

    PubMed  CAS  Google Scholar 

  106. Martin RC, Klimstra DS, Schwartz L, Yilmaz A, Blumgart LH, Jarnagin W. Hepatic intraductal oncocytic papillary carcinoma. Cancer 2002, 95: 2180–7.

    PubMed  Google Scholar 

  107. Terada T, Taniguchi M. Intraductal oncocytic papillary neoplasm of the liver. Pathol Int 2004, 54: 116–23.

    PubMed  Google Scholar 

  108. Frexinos J, Ribet A. Oncocytes in human chronic pancreatitis. Digestion 1972, 7: 294–301.

    PubMed  CAS  Google Scholar 

  109. Tasso F, Sarles H. Canalicular cells and oncocytes in the human pancreas. Comparative study on the normal condition and in chronic pancreatitis. Ann Anat Pathol (Paris) 1973, 18: 277–300.

    CAS  Google Scholar 

  110. Adsay NV, Adair CF, Heffess CS, Klimstra DS. Intraductal oncocytic papillary neoplasms of the pancreas. Am J Surg Pathol 1996, 20: 980–94.

    PubMed  CAS  Google Scholar 

  111. Adsay NV, Conlon KC, Zee SY, Brennan MF, Klimstra DS. Intraductal papillary-mucinous neoplasms of the pancreas: an analysis of in situ and invasive carcinomas in 28 patients. Cancer 2002, 94: 62–77.

    PubMed  Google Scholar 

  112. Albores-Saavedra J, Wu J, Crook T, Amirkhan RH, Jones L, Hruban RH. Intestinal and oncocytic variants of pancreatic intraepithelial neoplasia. A morphological and immunohistochemical study. Ann Diagn Pathol 2005, 9: 69–76.

    Google Scholar 

  113. Sugihara A, Nakasho K, Ikuta S, et al. Oncocytic non-functioning endocrine tumor of the pancreas. Pathol Int 2006, 56: 755–9.

    PubMed  Google Scholar 

  114. Lloyd RV, Mervak T, Schmidt K, Warner TF, Wilson BS. Immunohistochemical detection of chromogranin and neuron-specific enolase in pancreatic endocrine neoplasms. Am J Surg Pathol 1984, 8: 607–14.

    PubMed  CAS  Google Scholar 

  115. Dial PF, Braasch JW, Rossi RL, Lee AK, Jin GL. Management of nonfunctioning islet cell tumors of the pancreas. Surg Clin North Am 1985, 65: 291–9.

    PubMed  CAS  Google Scholar 

  116. Storkel S, Steart PV, Drenckhahn D, Thoenes W. The human chromophobe cell renal carcinoma: its probable relation to intercalated cells of the collecting duct. Virchows Arch B Cell Pathol Incl Mol Pathol 1989, 56: 237–45.

    PubMed  CAS  Google Scholar 

  117. Amin MB, Paner GP, Alvarado-Cabrero I, et al. Chromophobe renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 145 cases. Am J Surg Pathol 2008, 32: 1822–34.

    PubMed  Google Scholar 

  118. Dechet CB, Bostwick DG, Blute ML, Bryant SC, Zincke H. Renal oncocytoma: multifocality, bilateralism, metachronous tumor development and coexistent renal cell carcinoma. J Urol 1999, 162: 40–2.

    PubMed  CAS  Google Scholar 

  119. Perez-Ordonez B, Hamed G, Campbell S, et al. Renal oncocytoma: a clinicopathologic study of 70 cases. Am J Surg Pathol 1997, 21: 871–83.

    PubMed  CAS  Google Scholar 

  120. Cochand-Priollet B, Molinie V, Bougaran J, et al. Renal chromophobe cell carcinoma and oncocytoma. A comparative morphologic, histochemical, and immunohistochemical study of 124 cases. Arch Pathol Lab Med 1997, 121: 1081–6.

    CAS  Google Scholar 

  121. Kovacs G, Akhtar M, Beckwith BJ, et al. The Heidelberg classification of renal cell tumours. J Pathol 1997, 183: 131–3.

    PubMed  CAS  Google Scholar 

  122. Thoenes W, Storkel S, Rumpelt HJ. Human chromophobe cell renal carcinoma. Virchows Arch B Cell Pathol Incl Mol Pathol 1985, 48: 207–17.

    PubMed  CAS  Google Scholar 

  123. Taki A, Nakatani Y, Misugi K, Yao M, Nagashima Y. Chromophobe renal cell carcinoma: an immunohistochemical study of 21 Japanese cases. Mod Pathol 1999, 12: 310–7.

    PubMed  CAS  Google Scholar 

  124. Nagashima Y. Chromophobe renal cell carcinoma: clinical, pathological and molecular biological aspects. Pathol Int 2000, 50: 872–8.

    PubMed  CAS  Google Scholar 

  125. Thoenes W, Störkel S, Rumpelt HJ, Moll R, Baum HP, Werner S. Chromophobe cell renal carcinoma and its variants—a report on 32 cases. J Pathol 1988, 155: 277–87.

    PubMed  CAS  Google Scholar 

  126. Tickoo SK, Amin MB. Discriminant nuclear features of renal oncocytoma and chromophobe renal cell carcinoma. Analysis of their potential utility in the differential diagnosis. Am J Clin Pathol 1998, 110: 782–7.

    CAS  Google Scholar 

  127. Brown JA, Takahashi S, Alcaraz A, et al. Fluorescence in situ hybridization analysis of renal oncocytoma reveals frequent loss of chromosomes Y and 1. J Urol 1996, 156: 31–5.

    PubMed  CAS  Google Scholar 

  128. Brunelli M, Eble JN, Zhang S, Martignoni G, Delahunt B, Cheng L. Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma. Mod Pathol 2005, 18: 161–9.

    PubMed  CAS  Google Scholar 

  129. Paner GP, Lindgren V, Jacobson K, et al. High incidence of chromosome 1 abnormalities in a series of 27 renal oncocytomas: cytogenetic and fluorescence in situ hybridization studies. Arch Pathol Lab Med 2007, 131: 81–5.

    PubMed  Google Scholar 

  130. Bugert P, Gaul C, Weber K, et al. Specific genetic changes of diagnostic importance in chromophobe renal cell carcinomas. Lab Invest 1997, 76: 203–8.

    PubMed  CAS  Google Scholar 

  131. Kovacs A, Kovacs G. Low chromosome number in chromophobe renal cell carcinomas. Genes Chromosomes Cancer 1992, 4: 267–8. 17xc

    PubMed  CAS  Google Scholar 

  132. Brunelli M, Delahunt B, Ficarra V, et al. Utility of tissue microarrays for assessment of chromosomal abnormalities in chromophobe renal cell carcinoma. Anal Quant Cytol Histol 2009, 31: 401–9.

    PubMed  Google Scholar 

  133. Suvarna SK, Stephenson TJ. Oxyphil metaplasia of adrenal cortex secondary to metyrapone therapy. Histopathology 2001, 39: 546–7.

    PubMed  CAS  Google Scholar 

  134. Kloos RT, Gross MD, Francis IR, Korobkin M, Shapiro B. Incidentally discovered adrenal masses. Endocr Rev 1995, 16: 460–84.

    PubMed  CAS  Google Scholar 

  135. Erlandson RA, Reuter VE. Oncocytic adrenal cortical adenoma. Ultrastruct Pathol 1991, 15: 539–47.

    PubMed  CAS  Google Scholar 

  136. Sasano H, Suzuki T, Sano T, Kameya T, Sasano N, Nagura H. Adrenocortical oncocytoma. A true nonfunctioning adrenocortical tumor. Am J Surg Pathol 1991, 15: 949–56.

    CAS  Google Scholar 

  137. Bisceglia M, Ludovico O, Di Mattia A, et al. Adrenocortical oncocytic tumors: report of 10 cases and review of the literature. Int J Surg Pathol 2004, 12: 231–43.

    PubMed  Google Scholar 

  138. Akatsu T, Kameyama K, Araki K, Ashizawa T, Wakabayashi G, Kitajima M. Functioning adrenocortical oncocytoma: the first documented case producing interleukin-6 and review of the literature. J Endocrinol Invest 2008, 31: 68–73.

    PubMed  CAS  Google Scholar 

  139. Sasano H, Sato F, Shizawa S, Nagura H, Coughtrie MW. Immunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. Mod Pathol 1995, 8: 891–6.

    PubMed  CAS  Google Scholar 

  140. Wajchenberg BL, Albergaria Pereira MA, Medonca BB, et al. Adrenocortical carcinoma: clinical and laboratory observations. Cancer 2000, 88: 711–36.

    PubMed  CAS  Google Scholar 

  141. Ohtake H, Kawamura H, Matsuzaki M, et al. Oncocytic adrenocortical carcinoma. Ann Diagn Pathol 2010, 14: 204–8.

    PubMed  Google Scholar 

  142. Pitman MB, Young RH, Clement PB, Dickersin GR, Scully RE. Endometrioid carcinoma of the ovary and endometrium, oxyphilic cell type: a report of nine cases. Int J Gynecol Pathol 1994, 13: 290–301.

    PubMed  CAS  Google Scholar 

  143. Young RH, Scully RE. Oxyphilic tumors of the female and male genital tracts. Semin Diagn Pathol 1999, 16: 146–61.

    PubMed  CAS  Google Scholar 

  144. Parkin DM, Bray F, FerlayJ, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005, 55: 74–108.

    PubMed  Google Scholar 

  145. Pinto JA, Gonzalez JE, Granadillo MA. Primary carcinoma of the prostate with diffuse oncocytic changes. Histopathology 1994, 25: 286–8.

    PubMed  CAS  Google Scholar 

  146. Ordonez NG, Ro JY, Ayala AG. Lesions described as nodular mesothelial hyperplasia are primarily composed of histiocytes. Am J Surg Pathol 1998, 22: 285–92.

    PubMed  CAS  Google Scholar 

  147. Emerson RE, Ulbright TM. Morphological approach to tumours of the testis and paratestis. J Clin Pathol 2007, 60: 866–80.

    PubMed  PubMed Central  Google Scholar 

  148. Al-Agha OM, Axiotis CA. An in-depth look at Leydig cell tumor of the testis. Arch Pathol Lab Med 2007, 131: 311–7.

    PubMed  Google Scholar 

  149. Stanley RJ, DeSanto LW, Weiland LH. Oncocytic and oncocytoid carcinoid tumors (well-differentiated neuroendocrine carcinomas) of the larynx. Arch Otolaryngol Head Neck Surg 1986, 112: 529–35.

    PubMed  CAS  Google Scholar 

  150. Sajjad SM, Mackay B, Lukeman JM. Oncocytic carcinoid tumor of the lung. Ultrastruct Pathol 1980, 1: 171–6.

    PubMed  CAS  Google Scholar 

  151. Gotchall J, Traweek ST, Stenzel P. Benign oncocytic endocrine tumor of the pancreas in a patient with polyarteritis nodosa. Hum Pathol 1987, 18: 967–9.

    PubMed  CAS  Google Scholar 

  152. Dominguez-Malagon H, Delgado-Chavez R, Torres-Najera M, Gould E, Albores-Saavedra J. Oxyphil and squamous variants of medullary thyroid carcinoma. Cancer 1989, 63: 1183–8.

    PubMed  CAS  Google Scholar 

  153. Moran CA, Suster S. Primary neuroendocrine carcinoma (thymic carcinoid) of the thymus with prominent oncocytic features: a clinicopathologic study of 22 cases. Mod Pathol 2000, 13: 489–94.

    PubMed  CAS  Google Scholar 

  154. Yamaji I, Iimura O, MitoT, Yoshida S, Shimamoto K, Minase T. An ectopic, ACTH producing, oncocytic carcinoid tumor of the thymus: report of a case. Jpn J Med 1984, 23: 62–6.

    PubMed  CAS  Google Scholar 

  155. Hannah J, Lippe B, Lai-Goldman M, Bhuta S. Oncocytic carcinoid of the kidney associated with periodic Cushing’s syndrome. Cancer 1988, 61: 2136–40.

    PubMed  CAS  Google Scholar 

  156. Gaffney EF, Doorly T, Dinn JJ. Aggressive oncocytic neuroendocrine tumour (‘oncocytic paraganglioma’) of the cauda equina. Histopathology 1986, 10: 311–9.

    PubMed  CAS  Google Scholar 

  157. Radi MJ, Fenoglio-Preiser CM, Chiffelle T. Functioning oncocytic islet-cell carcinoma. Report of a case with electron-microscopic and immunohistochemical confirmation. Am J Surg Pathol 1985, 9: 517–24.

    CAS  Google Scholar 

  158. Cassarino DS, Santi M, Arruda A, et al. Spinal adrenal cortical adenoma with oncocytic features: report of the first intramedullary case and review of the literature. Int J Surg Pathol 2004, 12: 259–64.

    PubMed  Google Scholar 

  159. Schittenhelm J, Ebner FH, Harter P, Bornemann A. Symptomatic intraspinal oncocytic adrenocortical adenoma. Endocr Pathol 2009, 20: 73–7.

    PubMed  Google Scholar 

  160. Jih DM, Morgan MB, Bass J, Tuthill R, Somach S. Oncocytic metaplasia occurring in a spectrum of melanocytic nevi. Am J Dermatopathol 2002, 24: 468–72.

    PubMed  Google Scholar 

  161. Jih DM, Morgan MB, Bass J, Tuthill R, Somach SC. Oncocytic metaplasia occurring in melanoma. Semin Cutan Med Surg 2004, 23: 73–79.

    PubMed  Google Scholar 

  162. Coburn V, Radfar A, Snook D, Mahalingam M. Cutaneous oncocytoma — a report of three cases and review of the literature. J Cutan Pathol 2007, 34: 355–9.

    PubMed  Google Scholar 

  163. Hamperl H. Benign and malignant oncocytoma. Cancer 1962, 15: 1019–27.

    PubMed  CAS  Google Scholar 

  164. Tallini G. Oncocytic tumours. Virchows Arch 1998, 433: 5–12.

    PubMed  CAS  Google Scholar 

  165. Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989, 1: 642–5.

    PubMed  CAS  Google Scholar 

  166. Máximo V, Lima J, Soares P, Sobrinho-Simões M. Mitochondria and cancer. Virchows Arch 2009, 454: 481–95.

    PubMed  Google Scholar 

  167. Kimura HJ, Chen CY, Tzou SC, et al. Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice. PLoS One 2009, 4: e7857.

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA

    F. Guaraldi, G. Zang & P. Caturegli MD, MPH

  2. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, USA

    A. P. Dackiw

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  1. F. Guaraldi
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  2. G. Zang
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  3. A. P. Dackiw
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  4. P. Caturegli MD, MPH
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Correspondence to P. Caturegli MD, MPH.

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Guaraldi, F., Zang, G., Dackiw, A.P. et al. Oncocytic mania: A review of oncocytic lesions throughout the body. J Endocrinol Invest 34, 383–394 (2011). https://doi.org/10.1007/BF03347464

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