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Efficacy of long-term growth hormone therapy in short children with reduced growth hormone biological activity

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Abstract

Aim: The optimal GH regimen, in terms of cost-effectiveness, in children with normal GH immunoreactivity but reduced bioactivity is still debated. Methods: In 12 GH-deficient (GHD) and 12 bioinactive GH children undergoing GH treatment we evaluated the increase in growth velocity, the difference between target height and final stature and the incremental cost-effectiveness ratio. Results: We found a significant (p<0.05) increase in growth velocity in both groups during the first year of GH treatment (non-GHD: from −1.7 to 5.4 SDS; GHD: from −1.46 to 4.74 SDS). There was no statistically significant variation between the two groups in the difference between final height and target height. We did not find any significant difference in cost/height gain between GHD (1925.28±653.15 euro) and bioinactive GH children (1639.55±631.44 euro). There were also no significant differences in cost/year of therapy between GHD (12347.68±2018.1 euro) and bioinactive GH children (11355.08±1747.61 euro). Conclusion: In children with reduced GH biological activity, confirmed by the increase of serum IGF-I levels during generation test, the cost of GH treatment is justified by the positive results obtained in growth and adult height as in classical GHD patients.

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Authors and Affiliations

  1. Dipartimento di Scienze Pediatriche, Università degli Studi di Pavia, Piazzale C. Golgi 19, 27100, Pavia, Italy

    S. Pagani, C. Meazza, K. Laarej, F. Cantoni & Mauro Bozzola

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  1. S. Pagani
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  2. C. Meazza
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  3. K. Laarej
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  4. F. Cantoni
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  5. Mauro Bozzola
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Correspondence to Mauro Bozzola.

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Pagani, S., Meazza, C., Laarej, K. et al. Efficacy of long-term growth hormone therapy in short children with reduced growth hormone biological activity. J Endocrinol Invest 34, 366–369 (2011). https://doi.org/10.1007/BF03347461

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