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Calcium supply, bone mineral density and genetically defined lactose maldigestion in a cohort of elderly men

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Abstract

Objective: To examine a relationship of molecularly defined lactose malabsorption (LM; by LCT-polymorphism) to calcium supply, bone mineral density (BMD) and parameters of bone metabolism in an elderly male cohort. Furthermore, to reveal gender differences in BMD, calcium consumption rates and parameters of bone metabolism according to LCT polymorphism in an existing female cohort. Setting and subjects: A total of 239 men, aged 61 ±9 yr, were available from a former population based study cohort. All men were of Caucasian origin and came from the same region. Blood was sampled for genotyping of the LCT polymorphism and determination of markers of bone metabolism. All participants underwent physical examination, measurement of bone density and completed a standardized calcium questionnaire. Identical procedures had been carried out in a female cohort before (no. 350). Results: Distribution of the LCT genotype in the study cohort was 27% CC (associated with LM; adulttype hypolactasia), 55% TC and 18% TT (lactase persistence). Amounts of total ingested calcium were similar among the three genotype groups. Amounts of consumed milk were generally low in men, LCT polymorphism did not influence rates of milk consumption for men preferred other sources of calcium. BMD, markers of bone metabolism and fracture rates did not differ. General anthropometric characteristics did not differ between the LCT groups either. Conclusions: Under conditions of low milk intake LCT polymorphism does not alter bone density, markers of bone metabolism and fractures in this cohort of elderly Caucasian men.

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References

  1. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvela I. Identification of a variant associated with adult type hypolactasia. Nat Genet 2002, 30: 233–7.

    Article  CAS  PubMed  Google Scholar 

  2. Sahi T, Isokoksi M, Jussila J. Recessive inheritance of adulttype lactose malabsorption. Lancet 1973, 2: 823–6.

    Article  CAS  PubMed  Google Scholar 

  3. Swallow DM. Genetics of lactase persistence and lactose intolerance. Annu Rev Genet 2003, 37: 197–219.

    Article  CAS  PubMed  Google Scholar 

  4. Hoegenauer C, Hammer HF, Mellitzer K, Renner W, Krejs GJ, Toplak H. Evaluation of a new DNA test compared with the lactose hydrogen breath testforthe diagnosis of lactase non-persistence. Eur J Gastroenterol Hepatol 2005, 17: 371–6.

    Article  CAS  Google Scholar 

  5. Birge SJ, Keutmann HT, Cuatrecasas P. Osteoporosis, intestinal lactase deficiency and low dietary calcium intake. N Engl J Med 1967, 276: 445–8.

    Article  CAS  PubMed  Google Scholar 

  6. Newcomer AD, Hodgson SF, McGill DB, Thomas PJ. Lactase deficiency: Prevalence in osteoporosis. Ann Intern Med 1978, 89: 218–20.

    Article  CAS  PubMed  Google Scholar 

  7. Callegari C, Lami F, Levantesi F, et al. Post-menopausal bone density, lactase deficiency and milk consumption. J Hum Nutr 1990 3: 159–64.

    Article  Google Scholar 

  8. Di Stefano M, Veneto G, Malservisi S, Cechetti L, Strocchi A, Corazza GR. Lactose malabsorption and intolerance and peak bone mass. Gastroenterology 2002, 122: 1793–9.

    Article  PubMed  Google Scholar 

  9. Harma M, Alhava E. Is lactose malabsorption a risk factor in fractures of the elderly? Ann Chir Gynaecol 1988, 77: 180–3.

    CAS  PubMed  Google Scholar 

  10. Slemenda CW, Christian JC, Hui S, Fitzgerald J, Johnston CC Jr. No evidence for an effect of lactase deficiency on bone mass in pre-, or postmenopausal women. J Bone Miner Res 1991, 6: 1367–71.

    Article  CAS  PubMed  Google Scholar 

  11. Hammer HF, Petritsch W, Pristautz H, Krejs GJ. Assessment of the influence of hydrogen nonexrition on the usefulness of the hydrogen breath test and lactose tolerance test. Wien Klin Wochenschr 1996, 108: 137–41.

    CAS  PubMed  Google Scholar 

  12. Cochet B, Jung A, Griessen M. Effects of lactose on intestinal calcium absorption in normal and lactase-deficient subjects. Gastroenterology 1986, 84: 935–40.

    Google Scholar 

  13. Tremaine WJ, Newcomer AD, Riggs BL, McGill DB. Calcium absorption from milk in lactase deficient and lactase-sufficient adults. Dig Dis Sci 1986, 31: 376–8.

    Article  CAS  PubMed  Google Scholar 

  14. Obermayer-Pietsch BM, Bonelli CM, Walter DE, et al. Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J Bone Miner Res 2004, 19: 42–7.

    Article  PubMed  Google Scholar 

  15. Enattah NS, Ville-Valteri V, Välimäki MJ, Löyttyniemi E, Sahi T, Järvelä I. Molecularly defined lactose malabsorption, peak bone mass and bone turnover rate in young Finnish men. Calcif Tissue Int 2004, 75: 488–93.

    Article  CAS  PubMed  Google Scholar 

  16. Kudlacek S, Schneider B, Peterlik M, Leb G, Klaushofer K. Normative data of bone mineral density in an unselected adult Austrian population. Eur J Clin Invest 2003, 3: 332–9.

    Article  Google Scholar 

  17. WHO. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of WHO study group. WHO technical report series 843, Geneva. 1994.

  18. Zittermann A, Bock P, Drummer C, Scheld K, Heer M, Stehle P. Lactose does not enhance calcium bioavailability in lactose-tolerant, healthy adults. Am J Clin Nutr 2000, 71: 931–6.

    CAS  PubMed  Google Scholar 

  19. Reid IR, Pybus J, Lim MT, Hannon S, Ibbertson HK. The assessment of intestinal calcium absorption using stable strontium. Calcif Tissue Int 1986, 38: 303–5.

    Article  CAS  PubMed  Google Scholar 

  20. Blumsohn A, Morris B, Eastell R. Stable strontium absorption as a measure of intestinal calcium absorption: comparison with the double-radiotracer calcium absorption test. Clin Sci (Lond) 1994, 87: 363–8.

    CAS  Google Scholar 

  21. Sips AJ, Netelenbos JC, Barto R, Lips P, van der Vijgh WJ. One hour test for estimating intestinal absorption of calcium by using stable strontium as a marker. Clin Chem 1994, 40: 257–9.

    CAS  PubMed  Google Scholar 

  22. Kudlacek S, Schneider B, Peterlik M, Leb G, Klaushofer K. Assessment of vitamin D and calcium status in healthy adult Austrians. Eur J Clin Invest 2003, 33: 323–31.

    Article  CAS  PubMed  Google Scholar 

  23. Kumpalainen J, Tahvonen R. Report on the activities of the subnetwork on trace element status in food. In: Report on the consultation of the FAO European Cooperative Research Network on the Trace Elements. 1989 Lausanne, Switzerland. 5–8 Septmeber 1989, Rome: FAO. 1989: 37.

    Google Scholar 

  24. Honkanen R, Pulkkinen P, Jarvinen R, et al. Does lactose intolerance predispose to low bone density? A population based study of perimenopausal Finnish women. Bone 1996, 19: 23–8.

    Article  CAS  PubMed  Google Scholar 

  25. Gugatschka M, Dobnig H, Fahrleitner-Pammer A, et al. Clinical relevance of molecularly defined lactose malabsorption and relation of milk consumption to anthropometric differences in men. QJM 2005, 98: 857–63.

    Article  CAS  PubMed  Google Scholar 

  26. Carroccio A, Montalbo G, Cavera G, Notarbartolo A. Lactose intolerance and self reported milk-intolerance: relationship with lactose maldigestion and nutrient intake. J Am Coll Nutr 1998, 17: 631–6.

    Article  CAS  PubMed  Google Scholar 

  27. Corrazza GR, Benati G, di Sario G, et al. Lactose intolerance and bone mass in postmenopausal Italian women. Brit J Nutr 1995, 73: 479–87.

    Article  Google Scholar 

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Authors and Affiliations

  1. Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University, Graz, Austria

    M. Gugatschka MD (Doctor of Medical Sciences), A. Hoeller, A. Fahrleitner-Pammer, H. Dobnig & B. Obermayer-Pietsch

  2. Division of Pathophysiology, Medical University, Austria

    P. Pietschmann

  3. Department of Internal Medicine, Hospital of the Brothers of Charity, Vienna, Austria

    S. Kudlacek

Authors
  1. M. Gugatschka MD
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  2. A. Hoeller
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  3. A. Fahrleitner-Pammer
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  4. H. Dobnig
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  5. P. Pietschmann
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  6. S. Kudlacek
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  7. B. Obermayer-Pietsch
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Correspondence to M. Gugatschka MD.

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Gugatschka, M., Hoeller, A., Fahrleitner-Pammer, A. et al. Calcium supply, bone mineral density and genetically defined lactose maldigestion in a cohort of elderly men. J Endocrinol Invest 30, 46–51 (2007). https://doi.org/10.1007/BF03347395

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  • DOI: https://doi.org/10.1007/BF03347395

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