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Occurrence of lymphocyte proliferative response to thyroglobulin and antithyroglobulin antibodies in normal individuals: lack of correlation with HLA

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Abstract

Peripheral mononuclear cells (MNC) of patients with autoimmune thyroid disease have been shown to proliferate when cultured with human thyroglobulin (hTg). In addition, such a phenomenon is apparent in a certain number of healthy individuals. In this study we have attempted to correlate hTg-induced MNC proliferation, occurrence of anti-hTg autoantibodies and HLA phenotype (including Class II DR and DQ loci) in a population of HLA-typed normal blood donors. Fourteen out of 56 subjects showed a significant MNC proliferation to hTg. Three of them had anti-hTg autoantibodies in the serum, while none of the hTg-unresponsive subjects showed such antibodies. No correlation with HLA phenotype (including Class II DR5 specificity, referred as associated with Hashimoto’s thyroiditis, and DQ alleles) was observed.

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Authors and Affiliations

  1. Istituto Scientifico di Medicina Interna, Cattedra di Semeiotica Medica III, University of Genova, V.le Benedetto XV 6, 16132, Genova, Italy

    M. Bagnasco M.D. & D. Venuti

  2. Istituto Nazionale per la Ricerca sul Cancro, 16100, Genova, Italy

    A. Orlandini & G. B. Ferrara

  3. Cattedra di Endocrinologia, University of Genova, Genova, Italy

    G. Melioli

  4. Istituto di Microbiologia, University of Genova, Genova, Italy

    G. W. Canonica

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  1. M. Bagnasco M.D.
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  2. A. Orlandini
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  3. G. Melioli
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  4. D. Venuti
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  5. G. W. Canonica
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  6. G. B. Ferrara
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Bagnasco, M., Orlandini, A., Melioli, G. et al. Occurrence of lymphocyte proliferative response to thyroglobulin and antithyroglobulin antibodies in normal individuals: lack of correlation with HLA. J Endocrinol Invest 10, 203–206 (1987). https://doi.org/10.1007/BF03347192

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  • DOI: https://doi.org/10.1007/BF03347192

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