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Occurrence of lymphocyte proliferative response to thyroglobulin and antithyroglobulin antibodies in normal individuals: lack of correlation with HLA

Journal of Endocrinological Investigation volume 10, pages 203–206 (1987)Cite this article

Abstract

Peripheral mononuclear cells (MNC) of patients with autoimmune thyroid disease have been shown to proliferate when cultured with human thyroglobulin (hTg). In addition, such a phenomenon is apparent in a certain number of healthy individuals. In this study we have attempted to correlate hTg-induced MNC proliferation, occurrence of anti-hTg autoantibodies and HLA phenotype (including Class II DR and DQ loci) in a population of HLA-typed normal blood donors. Fourteen out of 56 subjects showed a significant MNC proliferation to hTg. Three of them had anti-hTg autoantibodies in the serum, while none of the hTg-unresponsive subjects showed such antibodies. No correlation with HLA phenotype (including Class II DR5 specificity, referred as associated with Hashimoto’s thyroiditis, and DQ alleles) was observed.

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Affiliations

  1. Istituto Scientifico di Medicina Interna, Cattedra di Semeiotica Medica III, University of Genova, V.le Benedetto XV 6, 16132, Genova, Italy

    M. Bagnasco M.D. & D. Venuti

  2. Istituto Nazionale per la Ricerca sul Cancro, 16100, Genova, Italy

    A. Orlandini & G. B. Ferrara

  3. Cattedra di Endocrinologia, University of Genova, Genova, Italy

    G. Melioli

  4. Istituto di Microbiologia, University of Genova, Genova, Italy

    G. W. Canonica

Authors
  1. M. Bagnasco M.D.
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  2. A. Orlandini
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  3. G. Melioli
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  4. D. Venuti
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  5. G. W. Canonica
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  6. G. B. Ferrara
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Bagnasco, M., Orlandini, A., Melioli, G. et al. Occurrence of lymphocyte proliferative response to thyroglobulin and antithyroglobulin antibodies in normal individuals: lack of correlation with HLA. J Endocrinol Invest 10, 203–206 (1987). https://doi.org/10.1007/BF03347192

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  • DOI: https://doi.org/10.1007/BF03347192

Key-words

  • Thyroglobulin
  • antithyroglobulin antibodies
  • HLA
  • lymphocytes