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Luteinizing hormone pulsatile secretion and pituitary response to gonadotropin releasing hormone and to thyrotropin releasing hormone in male epileptic subjects on chronic phenobarbital treatment

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Abstract

Endocrine changes have been reported in treated epileptic subjects, who often exhibit sexual dysfunctions, but the endocrine effects of single antiepileptic drugs have not been completely elucidated. In this study we have investigated the influence of phenobarbital (PB) on adenopituitary function and on peripheral sexual steroid pattern in 8 epileptic males. Chronic PB treatment does not modify luteinizing hormone (LH) pulsatile secretion. In the same subjects, LH and follicle stimulating hormone (FSH) response to Gonadotropin Releasing Hormone was blunted with respect to healthy controls both in terms of absolute values and of secretion areas. No difference was; found in prolactin (PRL) response to Thyrotropin Releasing Hormone. In the epileptic group a significant increase in the levels of sex hormone binding globulin and a consequent decrease of the percent free testosterone have been observed. PB treatment also significantly lowers 17-β-estradiol mean levels. These data suggest that PB independently affects both gonadotropin secretion and peripheral steroid pattern.

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References

  1. Toone B.K., Edeh J., Fenwick P., Grant R., Nanjee N., Purches A.C., Wheeler M. Hormonal and behavioural changes in male epileptics. In: Roger J., Porter R.J., Mattson R.H., Ward Jr A.A., Dam M. (Eds.), Advances in Epileptology: XVth Epilepsy International Symposium. Raven Press, New York, 1984, p. 283.

    Google Scholar 

  2. London D.R. Hormonal effects of anticonvulsant drugs. In: Canger R., Angeleri F., Penry Jr J.K. (Eds.), Advances in Epileptology. Xlth Epilepsy International Symposium. Raven Press, New York, 1980, p. 399.

    Google Scholar 

  3. Richens A. Enzyme induction and sex hormones. In: Roger J., Porter R.J., Mattson R.H., Ward Jr A.A., Dam M. (Eds.), Advances in Epileptology: XVth Epilepsy International Symposium. Raven Press, New York, 1984, p. 215.

    Google Scholar 

  4. Trimble M.R., Dana-Haeri J., Oxley J., Baylis P.H. Some neuroendocrine consequences of seizures. In: Roger J., Porter R.J., Mattson R.H., Ward Jr A.A., Dam M. (Eds.), Advances in Epileptology: XVth Epilepsy International Symposium. Raven Press, New York, 1984, p. 201.

    Google Scholar 

  5. Kupferberg H.J. Quantitative estimation of diphenylhydantoin, primidone and phenobarbital in plasma by gasliquid chromatography. Clin. Chim. Acta 29: 283, 1970.

    Article  CAS  Google Scholar 

  6. Anderson D.C., Peppiatt R., Schuster L., Fisher R. A new method for measurement of sex hormone-binding globulin in plasma and its clinical application. J. Endocrinol. 55: XI, 1972.

    PubMed  CAS  Google Scholar 

  7. Santen R.J., Bardin C.W. Episodic luteinizing hormone secretion in man. J. Clin. Invest. 52: 2617, 1973.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  8. Anderson D.C., Thorner M.O., Fisher R.A., Woodham J.P., Goble H.L., Besser G.M. Effects of hormonal treatment on plasma unbound androgen levels in hirsute women. Acta Endocrinol. (Kbh.) 80(Suppl. 199): 224, 1975.

    Google Scholar 

  9. Toone B.K., Wheeler M., Fenwick P.B.C. Sex hormone changes in male epileptics. Clin. Endocrinol. (Oxf.) 12: 391, 1980.

    Article  CAS  Google Scholar 

  10. Rodin E., Subramanian M.G., Gilroy J. Investigation of sex hormones in males epileptic patients. Epilepsia 25: 690, 1984.

    Article  PubMed  CAS  Google Scholar 

  11. Dunn J.F., Nisula B.C., Rodbard D. Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J. Clin. Endocrinol. Metab. 53: 58, 1981.

    Article  PubMed  CAS  Google Scholar 

  12. Masala A., Meloni T., Alagna S., Rovasio P.P., Mele G., Franca V. Pituitary responsiveness to gonadotrophin- releasing and thyrotropin- releasing hormones in children receiving phenobarbitone. Br. Med. J. 281: 1175, 1980.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  13. Dana-Haeri J., Oxley J., Richens A. Pituitary responsiveness to gonadotropin- releasing and thyrotrophin- releasing hormones in epileptic patients receiving carbamazepine or Phenytoin. Clin. Endocrinol. (Oxf.) 20: 163, 1984.

    Article  CAS  Google Scholar 

  14. Tartara A., Manni R., Delodovici M.L., Bonura M.L., Murialdo G. Pituitary function, testosterone and SHBG levels in treated epileptic male subjects. In: Roger J., Porter R.J., Mattson R.H., Ward Jr A.A., Dam M. (Eds.), Advances in Epileptology: XVth Epilepsy International Symposium. Raven Press, New York, 1984, p. 209.

    Google Scholar 

  15. Vanhaelst L.; Goldstein J., L’Hermite M., Robyn C., Leclercq R., Bruno O.D., Copinschi G. Effects of dexamethasone and secobarbital on the pituitary response to thyrotropin releasing hormone (TRH) in man: synergistic inhibition of thyrotropin (TSH) release. Neuroendocrinology 16: 282, 1974.

    Article  PubMed  CAS  Google Scholar 

  16. Ticku M.K., Burch T.P., Thyagarajan R., Ramanjaneyulu R. Barbiturate interactions with benzodiazepine- GABA receptor- ionophore complex. In: Mandel P., DeFeudis F.V. (Eds.), CNS Receptors — From Molecular Pharmacology to Behavior. Advances in Biochemical Psychopharmacology, vol. 37. Raven Press, New York, 1983, p. 81.

    Google Scholar 

  17. Delitala G. Neurotransmitter control of anterior pituitary hormone secretion and its clinical implications in man. In: Besser G.M., Martini L. (Eds.), Clinical Neuroendocrinology, vol. 2. Academic Press, New York, 1982, p. 67.

    Chapter  Google Scholar 

  18. Cavagnini F., Schechter P.J., Invitti C., Dubini A., Fossati R., Müller E.E. Effect of gamma vinyl GABA, a GABA-mimetic compound, on hypothalamic pituitary function in man. In: Endröczi E., Angelucci L., de Wied D., Scapagnini U. (Eds.), Integrative Neurohumoral Mechanisms. Akadèmiai Kiadó, Budapest, 1983, p. 529.

    Google Scholar 

  19. Sharman D.S., Holzer P., Holtzbauer M. In vitro release of endogenous catecholamines from the neural and intermediate lobe of the hypophysis. Neuroendocrinology 34: 175, 1982.

    Article  PubMed  CAS  Google Scholar 

  20. Franceschi M., Perego L., Cavagnini F., Cattaneo A.G., Invitti C., Caviezel F., Ferini Strambi L., Smirne S. Effects of long-term antiepileptic therapy on the hypothalamic-pituitary axis in man. Epilepsia 25: 46, 1984.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Istituto Scientifico di Medicina Interna, University of Genova, Viale Benedetto XV 6, 16132, Genova, Italy

    Giovanni Murialdo, A. De Maria, M. L. Bonura & A. Polleri

  2. Clinica Neurologica, University of Pavia, 27100, Pavia, Italy

    R. Manni & A. Tartara

Authors
  1. Giovanni Murialdo
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  2. R. Manni
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  3. A. De Maria
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  4. M. L. Bonura
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  5. A. Polleri
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  6. A. Tartara
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Murialdo, G., Manni, R., De Maria, A. et al. Luteinizing hormone pulsatile secretion and pituitary response to gonadotropin releasing hormone and to thyrotropin releasing hormone in male epileptic subjects on chronic phenobarbital treatment. J Endocrinol Invest 10, 27–31 (1987). https://doi.org/10.1007/BF03347145

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  • DOI: https://doi.org/10.1007/BF03347145

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