Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease

Abstract

Basal T4, T3, TSH, prolactin and growth hormone levels were determined in several groups: patients with postnecrotic cirrhosis with hepatocellular carcinoma (n = 14); patients with postnecrotic cirrhosis but without hepatocellular carcinoma (n = 26); cholangiolar carcinoma (n = 9); and normal controls age-matched to within 5 yr of the liver disease subjects studied. In addition, TRH stimulation (400 μg TRH) was performed; TSH, prolactin and growth hormone responses over a 180-min time interval were evaluated for each subject. The responses observed varied between liver disease groups. The presence or absence of hepatocellular carcinoma was found to determine, at least in part, the type of response observed. Similarly, the presence or absence of hepatic encephalopathy determined, and/or reflected, at least in part, the type of response observed. Finally, for purposes of continuity, basal and TRH-stimulated levels of TSH, prolactin, growth hormone, T4 and T3 are compared in 3 settings of cirrhosis: alcoholic, nonalcoholic postnecrotic cirrhosis, and postnecrotic cirrhosis with hepatocellular carcinoma.

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Correspondence to David H. Van Thiel M.D..

Additional information

This work was supported in part by grants from the NIAAA, ≠ 5 RO1 AA04425, NIADDK, ≠ RO1 AM32556, and the Gastroenterology Medical Research Foundation of Southwestern Pennsylvania.

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Van Thiel, D.H., Tarter, R., Gavaler, J.S. et al. Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease. J Endocrinol Invest 9, 479–486 (1986). https://doi.org/10.1007/BF03346970

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Key-words

  • Cholangiolar carcinoma
  • hepatocellular carcinoma
  • postnecrotic cirrhosis
  • thyroid hormone
  • pituitary hormones
  • TRH responses