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Effects of ovary suppression by a long-acting GnRH-agonist on circulating GH, insulin-like growth factor I and insulin levels in women with polycystic ovary syndrome

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Abstract

Our aim was to investigate the effect of GnRH-agonist (GnRH-a) induced suppression of plasma sex steroids on serum GH, insulin like growth factor-l (IGF-I) and insulin levels after an oral glucose load (OGTT) in women with polycystic ovary syndrome (PCOS). Serum insulin, GH and IGF-I levels during a 75-g 4-h OGTT were measured in 3 nonobese and 7 obese hyperandrogenic women with PCOS and normal glucose tolerance before and after 10 weeks of treatment with the GnRH-a triptorelin (3, 75 mg im every 28 days). Basal estrogen and androgen levels were also measured at time 0 of the first and the second OGTT. After the therapy serum estrogens and androgens were significantly suppressed. Body weight remained unchanged. Basal GH significantly increased after the treatment while fasting IGF-I and insulin levels decreased from (mean±SE) 349.3±31.8 to 278.7±33.2 ng/mL and from 22.4±4.1 to 18.8±4.4 µU/mL, respectively. The insulin response to OGTT (area under curve) was also reduced (from 16017±2598 to 11736±2317 µU/mL/240 min). Our results suggest that the GnRH-a induced suppression of ovary secretion may modify the serum GH and IGF-I levels and the insulin response to an OGTT in women with PCOS.

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Authors and Affiliations

  1. Clinica Ostetrica e Ginecologica, Università Cattolica del S. Cuore, Roma, Italy

    G. Tropeano M.D., I. P. Vuolo, G. Caroli & P. Carfagna

  2. Biochimica, Università Cattolica del S. Cuore, Roma, Italy

    I. Liberale, A. Barini & E. Menini

Authors
  1. G. Tropeano M.D.
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  2. I. Liberale
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  3. I. P. Vuolo
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  4. A. Barini
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  5. G. Caroli
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  6. P. Carfagna
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  7. E. Menini
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Tropeano, G., Liberale, I., Vuolo, I.P. et al. Effects of ovary suppression by a long-acting GnRH-agonist on circulating GH, insulin-like growth factor I and insulin levels in women with polycystic ovary syndrome. J Endocrinol Invest 20, 220–224 (1997). https://doi.org/10.1007/BF03346907

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  • DOI: https://doi.org/10.1007/BF03346907

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