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Oxytocin does not modify the prolactin response to metoclopramide in normal women

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Abstract

The present study was undertaken in order to establish whether oxytocin (OT) affects the dopaminergic control of PRL secretion in normal women during follicular, periovulatory and luteal phase of their menstrual cycle. For this purpose, 22 normal women were tested with a lower (1 mg) or higher (10 mg) dose of the dopaminergic antagonist metoclopramide (MCP) with or without the concurrent treatment with OT (2 IU injected plus 0.033 IU/min infused for 2 h). Since OT was found unable to modify the effect of either 1 or 10 mg MCP, in additional experiments the same doses of MCP and OT were administered after dopamine (0.04 µg/kg/min for 2 h) infusion. Also in these experimental conditions OT failed to modify the PRL response to MCP. These data argue against a role of OT in modulation of the dopaminergic control of PRL secretion in normal women.

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Authors and Affiliations

  1. Cattedra di Endocrinologia e Patologia Costituzionale, Università di Parma, Via Gramsci 14, 43100, Parma, Italy

    Paolo Chiodera, L. Bianconi & C. Papadia

  2. Cattedra di Clinica Medica Generale, Università di Parma, Parma, Italy

    R. Volpi, A. Corradi, U. Cavazzini & V. Coiro

  3. Istituto di Ostetricia e Ginecologia, Università di Parma, Parma, Italy

    D. Gramellini

  4. Divisione di Ostetricia e Ginecologia, Ospedale di Reggio Emilia, Reggio Emilia, Italy

    C. Cigarini

  5. Divisione di Medicina Generale, Ospedale di Fidenza, Fidenza, Italy

    A. Caiazza

  6. Divisione di Medicina Generale, Ospedale di Codogno, Codogno, Italy

    L. Capretti

  7. Laboratorio RIA, Ospedale di Guastalla, Guastalla, Italy

    G. Rossi

Authors
  1. Paolo Chiodera
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  2. R. Volpi
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  3. D. Gramellini
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  4. C. Cigarini
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  5. A. Corradi
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  6. U. Cavazzini
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  7. L. Bianconi
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  8. C. Papadia
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  9. A. Caiazza
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  10. L. Capretti
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  11. G. Rossi
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  12. V. Coiro
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Chiodera, P., Volpi, R., Gramellini, D. et al. Oxytocin does not modify the prolactin response to metoclopramide in normal women. J Endocrinol Invest 14, 463–468 (1991). https://doi.org/10.1007/BF03346844

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  • DOI: https://doi.org/10.1007/BF03346844

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