Conclusion
The models shown in Figure 3, illustrating proposed interactions between MBH dopaminergic and endorphinergic neuronal activity as well as gonadal steroids and PRL in the regulation of GnRH secretion, Figures. 4 and 5, illustrating that these putative mechanisms may be mediated by other neuronal activity, and Figure 6, illustrating a hypothetical mechanism by which some other neuromodulators could integrate with this regulation, do appear to offer credible, although admittedly simplistic, mechanisms for much of the fundamental neuroendocrine regulation of reproduction. There are obvious limitations to these models, including the facts that all of the MBH dopaminergic or endorphinergic neurons most certainly do not serve the same functions or respond uniformly, that many undoubtably critical parameters have essentially been ignored, that species and sex differences have occasionally not been considered, and that interactions outside of the MBH are also clearly important, especially in the rat. Furthermore, the line between hypothesis and speculation has clearly been crossed in some instances. Nonetheless, when the consistently likely roles of these basic interactions in the full panorama of experimental and physiological functions discussed here are considered together, it is indeed apparent that these interactions between mediobasohypothalamic dopaminergic and endorphinergic neuronal systems probably represent key regulatory mechanisms in reproduction. However, I acknowledge the counsel of pioneering neuroscientist Santiago Ramon y Cajal, who wrote “I wish to warn young men against the invincible attraction of theories which simplify and unify seductively” (324) and thus offer these models only as heuristic bases for probing the actual, and clearly far more complex, physiological mechanisms.
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Rasmussen, D.D. The interaction between mediobasohypothalamic dopaminergic and endorphinergic neuronal systems as a key regulator of reproduction: an hypothesis. J Endocrinol Invest 14, 323–352 (1991). https://doi.org/10.1007/BF03346826
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DOI: https://doi.org/10.1007/BF03346826