Abstract
Background: Studies on fertility in women with Turner syndrome have shown that spontaneous pregnancies occur in about 2–7% of patients. Fertility problems and obstetrical complications are frequently observed in untreated patients with celiac disease. We report the case of a patient, affected by Turner syndrome and celiac disease, in whom a spontaneous pregnancy occurred. Case: One patient affected by Turner syndrome at the age of 30 yr conceived spontaneously. Celiac disease was diagnosed during pregnancy. The pregnancy progressed uneventfully. After 39 weeks of gestation, she vaginally delivered a normal male infant. Conclusion: Our patient had a successful pregnancy, giving birth to a healthy child, although she presented two pathological conditions affecting fertility and pregnancy outcome: Turner syndrome and celiac disease.
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Pasquino AM, Passeri F, Pucarelli I, Segni M, Municchi G. Spontaneous pubertal development in Turner’s syndrome. Italian Study Group forTurner’s Syndrome. J Clin Endocrinol Metab 1997, 82: 1810–3.
Elsheikh M, Dunger DB, Conway GS, Wass JA. Turner’s syndrome in adulthood. Endocr Rev 2002, 23: 120–40.
Livadas S, Xekouki P, Kafiri G, Voutetakis A, Maniati-Christidi M, Dacou-Voutetakis C. Spontaneous pregnancy and birth of a normal female from a woman with Turner syndrome and elevated gonadotropins. Fertil Steril 2005, 83: 769–72.
Tarani L, Lampariello S, Raguso G, et al. Pregnancy in patients with Turner’s sindrome: six new cases and review of literature. Gynecol Endocrinol 1998, 12: 83–7.
Fasano A. Clinical presentation of celiac disease in the pediatric population. Gastroenterology 2005, 128 (Suppl 1): S68–73.
Rostami K, Steegers EA, Wong WY, Braat DD, Steegers-Theunissen RP. Coeliac disease and reproductive disorders: a neglected association. Eur J Obstet Gynecol Reprod Biol 2001, 96: 146–9.
Stazi AV, Mantovani A. A risk factor for female fertility and pregnancy: celiac disease. Gynecol Endocrinol 2000, 14: 454–63.
Eliakim R, Sherer DM. Celiac disease: fertility and pregnancy. Gynecol Obstet Invest 2001, 51: 3–7.
Foschi F, Diani F, Zardini E, Zanoni G, Caramaschi P. Celiac disease and spontaneous abortion. Minerva Ginecol 2002, 54: 151–9.
Bonamico M, Pasquino AM, Mariani P, et al. Italian Society Of Pediatric Gastroenterology Hepatology (SIGEP); Italian Study Group for Turner Syndrome (ISGTS). Prevalence and clinical picture of celiac disease in Turner syndrome. J Clin Endocrinol Metab 2002, 87: 5495–8.
Gillett PM, Gillett HR, Israel DM, et al. Increased prevalence of celiac disease in girls with Turner syndrome detected using antibodies to endomysium and tissue transglutaminase. Can J Gastroenterol 2000, 14: 915–8.
Ivarsson SA, Carlsson A, Bredberg A, et al. Prevalence of coeliac disease in Turner syndrome. Acta Paediatr 1999, 88: 933–6.
Tanner JM, Whitehouse RH, Takaishi M. Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965._II. Arch Dis Child 1966, 41: 613–35.
Birkebaek NH, Crüger D, Hansen J, Nielsen J, Bruun-Petersen G. Fertility and pregnancy outcome in Danish women with Turner syndrome. Clin Genet 2002, 61: 35–9.
Practice Committee, American Society for Reproductive Medicine. Increased maternal cardiovascular mortality associated with pregnancy in women with Turner syndrome. Fertil Steril 2005, 83: 1074–5.
Tata LJ, Card TR, Logan RF, Hubbard RB, Smith CJ, West J. Fertility and pregnancy-related events in women with celiac disease: a population-based cohort study. Gastroenterology 2005, 128: 849–55.
Sheiner E, Peleg R, Levy A. Pregnancy outcome of patients with known celiac disease. Eur J Obstet Gynecol Reprod Biol 2006, 129: 41–5.
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Calcaterra, V., Lanzarini, L., Guerci, B. et al. Pregnancy in a woman with Turner syndrome and celiac disease. J Endocrinol Invest 30, 598–600 (2007). https://doi.org/10.1007/BF03346354
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DOI: https://doi.org/10.1007/BF03346354