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Azioni biologiche e metaboliche di obestatin, un peptide della famiglia del gene ghrelin

Proposto da Domenico Salvatore

  • Published:
L’Endocrinologo Aims and scope

Riassunto

Le azioni biologiche di obestatin sono tuttora controverse, probabilmente a causa della mancata identificazione di uno specifico recettore. Pochi studi concordano, infatti, sul legame tra obestatin e il GPR39 e altri suggeriscono l’interazione con altri siti di legame, tra cui il recettore del glucagon-like peptide-1. Il ruolo di obestatin è noto soprattutto nella regolazione dell’appetito, della proliferazione e della funzionalità di numerosi modelli cellulari, mentre resta ancora da chiarire un suo ruolo nella regolazione della secrezione insulinica.

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Authors and Affiliations

  1. Laboratorio di Endocrinologia Molecolare e Cellulare, Divisione di Endocrinologia, Diabetologia e Metabolismo, Dipartimento di Scienze Mediche, Università degli Studi di Torino, Corso Dogliotti 14, 10126, Torino, Italia

    Letizia Trovato, Eleonora Gargantini &  Riccarda Granata

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  1. Letizia Trovato
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  2. Eleonora Gargantini
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  3. Riccarda Granata
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Correspondence to Riccarda Granata.

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Trovato, L., Gargantini, E. & Granata, R. Azioni biologiche e metaboliche di obestatin, un peptide della famiglia del gene ghrelin. L’Endocrinologo 14, 239–242 (2013). https://doi.org/10.1007/BF03346110

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  • DOI: https://doi.org/10.1007/BF03346110

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