Riassunto
La malattia di Cushing è una patologia per la quale, a differenza di altri tumori ipofisari, non esiste una terapia farmacologica universalmente accettata ed efficace. Il farmaco più utilizzato è il chetoconazolo, un inibitore della steroidogenesi, dato che i farmaci che agiscono direttamente sui corticotropi tumorali hanno ottenuto solo di recente dei risultati promettenti. La loro efficacia è peraltro variabile ed è spesso necessario fare diversi tentativi terapeutici con farmaci che agiscono a livello ipofisario o surrenalico, da soli o in associazione.
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De Martin, M., Giraldi, F.P. Novità nella terapia medica della malattia di Cushing. L’Endocrinologo 13, 254–258 (2012). https://doi.org/10.1007/BF03346013
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DOI: https://doi.org/10.1007/BF03346013