Skip to main content

Growth factors in the ovary

This is a preview of subscription content, access via your institution.

References

  1. Greep R.O. Physiology of the anterior hypophysis in relation to reproduction. In: Young W.W.C. (Ed.), Sex and internal secretion, ed. 3, vol. 1. Williams and Wilkins, Baltimore, 1961, p. 240.

    Google Scholar 

  2. Richards J.S. Maturation of ovarian follicles: actions and interactions of pituitary and ovarian hormones on follicular cell differentiation. Physiol. Rev. 60:51, 1980.

    PubMed  CAS  Google Scholar 

  3. Hsueh A.J.W., Adashi E.Y., Jones P.B.C., Welsh Jr. T.H. Hormonal regulation of the differentiation of cultured ovarian granulosa cells. Endoc. Rev. 5:76, 1984.

    CAS  Google Scholar 

  4. Barreca A., Minuto F. Somatomedins: chemical and functional characteristics of the different molecular forms. J. Endocrinol. Invest. 12: 279, 1989.

    PubMed  CAS  Google Scholar 

  5. Rinderknecht E., Humbel R.E. The amino acid sequence of insulin-like growth factor I and its structural homology with proinsulin. J. Biol. Chem. 253:2769, 1978.

    PubMed  CAS  Google Scholar 

  6. Rinderknecht E., Humbel R.E. Primary structure of human insulin-like growth factor-II. FEBS Lett. 89:283, 1978.

    PubMed  CAS  Google Scholar 

  7. Jansen M., van Schaik F.M.A, van Tol H., Van Den Brande J.L., Sussenbach J.S. Nucleotide sequence analysis of cDNAs encoding precursors of human insulin-like growth factors II (IGF-II) and an IGF II variant. FEBS Lett. 179: 243, 1985.

    PubMed  CAS  Google Scholar 

  8. Jansen M., Van Schaik F.M.A., Ricker AT., Bullock B., Woods D.E., Gabbay K.H., Nussbaum A.L., Sussenbach J.S., Van Den Brande J.L. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature 306: 609, 1983.

    PubMed  CAS  Google Scholar 

  9. Bell G.I., Merryweather J.P., Sanchez-Pescador R., Stempien M.M., Priestley L, Scott J., Rail L.B. Sequence of a cDNA clone encoding human preproinsulin-like growth factor II. Nature 310:775, 1984.

    PubMed  CAS  Google Scholar 

  10. Tricoli J.V., Rail LB., Scott J., Bell G.I., Shows T.B. Localization of insulin-like growth factor genes to human chromosomes 11 and 12. Nature 310:784, 1984.

    PubMed  CAS  Google Scholar 

  11. Minuto F., Barreca A., Adami G.F., Fortini P., Del Monte P., Cella F., Scopinaro N., Giordano G. Somatomedin-C/insulin-like growth factor-I in malnutrition: Relationship with some body composition and nutritional parameters. J. Parenter. Enteral Nutrition 13:392, 1989.

    CAS  Google Scholar 

  12. Bradshaw R.A., Niall H.D. Insulin-related growth factors. TIBS 3: 274, 1978.

    CAS  Google Scholar 

  13. Blundell T.L., Humbel R.E. Hormone families: pancreatic hormones and homologous growth factors. Nature 287: 781, 1980.

    PubMed  CAS  Google Scholar 

  14. Perdue J.F. Chemistry, structure and function of insulin-like growth factors and their receptors: a review. Can. J. Biochem. Cell. Biol. 62:1237, 1984.

    PubMed  CAS  Google Scholar 

  15. D’Ercole A.J., Stiles A.D., Underwood L.E. Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc. Natl. Acad. Sci. USA 81: 935, 1984.

    PubMed Central  PubMed  Google Scholar 

  16. Zapf J., Waldvogel M., Froesch E.R. Binding of non-suppressible insulin-like activity to human serum. Evidence for a carrier protein. Arch. Biochem. Biophys. 168:638, 1975.

    PubMed  CAS  Google Scholar 

  17. Hintz R.L., Liu F. Demonstration of specific plasma protein binding sites for somatomedin. J. Clin. Endocrinol. Metab. 45:988, 1977.

    PubMed  CAS  Google Scholar 

  18. Ballard J., Baxter R., Binoux M., Clemmons D., Drop S., Hall K., Hintz R., Rechler M., Rutanen E., Schwander J. On the nomenclature of the IGF-I binding proteins. Acta Endocrinol. 727:751, 1989.

    Google Scholar 

  19. Moses A.C., Nissley S.P., Cohen K.L., Rechler M.M. Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone. Nature 263:137, 1976.

    PubMed  CAS  Google Scholar 

  20. White R.M., Nissley S.P., Moses A.C., Rechler M.M., Johnsonbaugh R.E. The growth hormone dependence of a serum so-matomedin-binding protein in human serum. J. Clin. Endocrinol. Metab. 53:49, 1981.

    PubMed  CAS  Google Scholar 

  21. Furlanetto R.W. The somatomedin C binding protein: evidence for a heterologous subunit structure. J. Clin. Endocrinol. Metab. 57:12, 1980.

    Google Scholar 

  22. Barreca A., Del Monte P., Fortini P., Canola G., Cella F., Minuto F. Sm-C/IGF-I binding proteins: role of the acid labile component of the 150 K complex. J. Endocrinol. Invest. 70(suppl. 1): 53, 1987.

    Google Scholar 

  23. Martin L.J., Baxter R.C. Antibody against acid-stable insulin-like growth factor binding protein detects 150,000 mol wt growth hormone dependent complex in human plasma. J. Clin. Endocrinol. Metab. 67:799, 1985.

    Google Scholar 

  24. Baxter R.C. Characterization of the acid-labile subunit of the growth hormone dependent insulin-like growth factor binding protein complex. J. Clin. Endocrinol. Metab. 67:265, 1988.

    PubMed  CAS  Google Scholar 

  25. Wood W.I., Cachianes G., Henzel W.J., Winslow G.A., Spencer S.A., Hellmis R., Martin J.L, Baxter R.C. Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein. Mol. Endocrinol. 2:1176, 1988.

    PubMed  CAS  Google Scholar 

  26. Brinkman A., Groffen C, Kortleve D.J., van Kessel A.G., Drop S.L.S. Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1). EMBO J. 7:2417, 1988b.

    PubMed Central  PubMed  CAS  Google Scholar 

  27. Julkunen M., Koistinen R., Aalto-Setala K., Seppala M., Janne O.A., Kontula K. Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA. FEBS Lett. 236: 295, 1988.

    PubMed  CAS  Google Scholar 

  28. Hammond J.M., Lino J., Baranao S., Skaleris D., Knight A.B. Romanus J.A., Rechler N. Production of insulin-like growth factors by ovari an granulosa cells. Endocrinology 117:2553, 1985.

    PubMed  CAS  Google Scholar 

  29. Murphy L.J., Bell G.I., Friesen H.G. Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat. Endocrinology 120:1279, 1987.

    PubMed  CAS  Google Scholar 

  30. Hernandez E.R., Roberts C.T., LeRoith D., Adashi E.Y. Rat ovarian insulin-like growth factor I (IGF-I) gene expression is granulosa cell-selective: 5’-un-translated mRNA variant representation and hormonal regulation. Endocrinology 725:579, 1989.

    Google Scholar 

  31. Oliver J.E., Timothy A.J., Powell J.F., Wilson C.A., Clayton R.N. Insulin-like growth factor I gene expression in the rat ovary is confined to the granulosa cells of developing follicles. Endocrinology 724:2671, 1989.

    Google Scholar 

  32. Davoren J.B., Hsueh A.J.W. Growth hormone increases ovarian levels of im-munoreactive somatomedin-C/insulin-like growth factor I in vivo. Endocrinology 778:888, 1984.

    Google Scholar 

  33. Hsu C.J., Hammond J.M. Concomitant effects of growth hormone on secretion of insulin-like growth factor I and progesterone by cultured porcine granulosa cells. Endocrinology 727:1343, 1987.

    Google Scholar 

  34. Hsu C.J., Hammond J.M. Gonadotropins and estradiol stimulate im-munoreactive insulin-like growth factor I by porcine granulosa cells in vitro. Endocrinology 720:198, 1987.

    Google Scholar 

  35. Mondschein J.S., Hammond J.M. Growth factors regulate immunoreactive insulinlike growth factor-l production by cultured porcine granulosa cells. Endocrinology 723:463, 1988.

    Google Scholar 

  36. Jia X.C., Kalmijn J.K., Hsueh A.J. Growth hormone enhances follicle-stimulating hormone induced differentiation of cultured rat granulosa cells. Endocrinology 118:1401, 1986.

    PubMed  CAS  Google Scholar 

  37. Bartke A. Histology of the anterior hypophysis, thyroid and gonads of two types of dwarf mice. Anat. Rec. 749:225, 1964.

    Google Scholar 

  38. Shimasaki S., Koba A., Mercado M., Shimonaka M., Ling N. Complementary DNA structure of the high molecular weight rat insulin-like growth factor binding protein (IGFBP-3) and tissue distribution of its mRNA. Biochem. Biophys. Res. Commun. 165: 907, 1989.

    PubMed  CAS  Google Scholar 

  39. Ui M., Shimonaka M., Shimasaki S., Ling N. An insulin-like growth factor-binding protein in ovarian follicular fluid blocks follicle-stimulating hormone stimulated steroid production by ovarian granulosa cells. Endocrinology 725:912, 1989.

    Google Scholar 

  40. Bicsak T.A., Shimonaka M., Malkovski M., Ling N. Insulin-like growth factor-binding protein (IGF-BP) inhibition of granulosa cell function: effect on cyclic adenosine 3’, 5’-monophosphate, deoxyribonucleic acid synthesis, and comparison with the effect of an IGF-I antibody. Endocrinology 726:2184, 1990.

    Google Scholar 

  41. Adashi E.Y., Resnick C.E., Hernandez E.R., Hurwitz A., Rosenfeld R.G. Follicle-stimulating hormone inhibits the constitutive release of insulin-like growth factor binding proteins by cultured rat ovarian granulosa cells. Endocrinology 126:1305, 1990.

    PubMed  CAS  Google Scholar 

  42. Adashi E.Y., Resnick C.E., Hurwitz A., Ricciarelli E., Hernandez H.R., Rosenfeld R.G. Ovarian granulosa cell-derived insulin-like growth factor binding proteins: modulatory role of follicle-stimulating hormone. Endocrinology 728:754, 1991.

    Google Scholar 

  43. Nakatani A., Shimasaki S., Erikson G.F., Ling N. Tissue-specific expression of four insulin-like growth factor-binding proteins (1, 2, 3 and 4) in the rat ovary. Endocrinology 729:1521, 1991.

    Google Scholar 

  44. Baranao J.L.S., Hammond J.M. Comparative effects of insulin and insulin-like growth factors on DNA synthesis and differentia tion of porcine granulosa cell. Biochem. Biophys. Res. Commun. 724: 484, 1984.

    Google Scholar 

  45. Veldhuis J.D., Furlanetto R.W. Trophic actions of human somatomedin-C/insulin-like growth factor I on ovarian cells: in vitro studies with swine granulosa cells. Endocrinology 116:1235, 1985.

    PubMed  CAS  Google Scholar 

  46. Adashi E.Y., Resnick C.E., Svoboda M.E., Van Wyk J.J. Follicle stimulating hormone enhances so-matomedin-C binding to cultured rat granulosa cells. Evidence for cAMP dependence. J. Biol. Chem. 267:3923, 1986.

    Google Scholar 

  47. Adashi E.Y., Resnick C.E., Hernandez E.R., Svoboda M.E., Van Wyk J.J. In vivo regulation of granulosa cells somatomedin-C/insulin like growth factor I receptors. Endocrinology 722:1383, 1988.

    Google Scholar 

  48. Adashi E.Y., Resnick C.E., Hernandez E.R., Svoboda M.E., Van Wyk J.J. Characterization and regulation of a specific cell membrane receptor for somatomedin-C/insulin-like growth factor I in cultured rat granulosa cells. Endocrinology 722:194, 1988.

    Google Scholar 

  49. Talavera F., Menon K.J.M. Studies on rat luteal cell response to insulin-like growth factor I (IGF-I): identification of a specific cell membrane receptor for IGF-I in the luteinized rat ovary. Endocrinology 129:1340, 1991.

    PubMed  CAS  Google Scholar 

  50. Poretsky L, Bhargava G., Levitan E. Type I insulin-like growth factor receptors in human ovarian stroma. Horm. Res. 33:26, 1990.

    Google Scholar 

  51. Adashi E.Y., Resnick C.E., Svoboda M.E., Van Wyk J.J. Somatomedin-C as an amplifier of follicle-stimu- lating hormone action: enhanced accumulation of adenosine 3′ 5′ cyclic monophosphate. Endocrinology 118:149, 1986.

    PubMed  CAS  Google Scholar 

  52. Adashi E.Y., Resnick C.E., Hernandez E.R., May J.V., Knecht M., Svoboda M.E., Van Wyk J.J. Insulin-like growth factor-l as an amplifier of follicle stimulating hormone action: studies on mechanism(s) and site(s) of action in cultured rat granulosa cells. Endocrinology 122:1583, 1988.

    PubMed  CAS  Google Scholar 

  53. Schams D., Koll R., Li C.H. Insulin-like growth factor-l stimulates oxytocin and progesterone production by bovine granulosa cells in culture. J. Endocrinol. 116: 97, 1987.

    Google Scholar 

  54. McArdle CA, Holtorf A.P. Oxytocin and progesterone release from bovine corpus luteal cells in culture: effects of insulin-like growth factor I, insulin, and prostaglandins. Endocrinology 124: 1278, 1989.

    PubMed  CAS  Google Scholar 

  55. Adashi E.Y., Resnick C.E., Svoboda M.E., Van Wyk J.J., Hascall V.C., Yanagishita M. Independent and synergistic action of somatomedin-C in the stimulation of proteoglycan biosynthesis by cultured rat granulosa cells. Endocrinology 118:456, 1986.

    CAS  Google Scholar 

  56. Zhiwen Z., Carson R.S., Herington A.D., Lee V.W.K., Burger H.G. Follicle-stimulating hormone and somatomedin-C stimulate inhibin production by rat granulosa cells in vitro. Endocrinology 120:1633, 1987.

    CAS  Google Scholar 

  57. Adashi E.Y., Resnick C.E., Brodie A.M.H., Svoboda M.E., Van Wyk J.J. Somatomedin-C mediated potentiation of follicle stimulating hormone-induced aromatase activity of cultured rat granulosa cells. Endocrinology 117:2313, 1985.

    PubMed  CAS  Google Scholar 

  58. Adashi E.Y., Resnick C.E., Svoboda M.E., Van Wyk J.J. Somatomedin-C synergises with follicle stimulating hormone in the acquisition of progestin biosynthetic capacity by cultured rat granulosa cells. Endocrinology 116:2135, 1985.

    PubMed  CAS  Google Scholar 

  59. Adashi E.Y., Resnick C.E., Svoboda M.E., Van Wyk J.J. Somatomedin-C enhances induction of luteinizing hormone receptors by follicle stimulating hormone in cultured rat granulosa cells. Endocrinology 116:2369, 1985.

    PubMed  CAS  Google Scholar 

  60. Erikson G.F., Garzo V.G., Magoffin D.A. Insulin-like growth factor-l regulates aromatase activity in human granulosa and granulosa luteal cells. J. Clin. Endocrinol. Metab. 69:716, 1989.

    Google Scholar 

  61. Hernandez E.R., Resnick C.E., Svoboda M.E., Van Wyk J.J., Payne D.W., Adashi E.Y. Somatomedin-C insulin growth factor I as an enhancer of androgen biosynthesis by cultured rat ovarian cells. Endocrinology 122: 1603, 1988.

    PubMed  CAS  Google Scholar 

  62. Veldhuis J.D., Rogers R.J., Dee A., Simpson E.R. The insulin-like growth factor, somatomedin-C, induces the synthesis of cholesterol side-chains cleavage cytochrome P-450 and adrenodoxin in ovarian cells. J. Biol. Chem. 261:2499, 1986.

    PubMed  CAS  Google Scholar 

  63. Veldhuis J.D., Nestler J.E., Strauss III J.F., Azimi P., Garmey J., Juchter D. The insulin-like growth factor I, somatomedin-C, modulates low density lipoprotein metabolism by swine granulosa cells. Endocrinology 121:340, 1987.

    PubMed  CAS  Google Scholar 

  64. Magoffin D.A., Kurtz K.M., Erickson G.F. Insulin-like growth factor-l selectively stimulates cholesterol side-chain cleavage expression in ovarian theca interstitial cells. Mol. Endocrinol. 4:489,??

  65. Poretsky L., Smith D., Seibel M., Pazianos A., Moses A.C., Flier J.S. Specific insulin binding sites in human ovary. J. Clin. Endocrinol. Metab. 59:809, 1984.

    PubMed  CAS  Google Scholar 

  66. Poretsky L., Grigorescu F., Seibel M., Moses A.C., Flier J.S. Distribution and characterization of insulin and insulin-like growth factor I receptors in normal human ovary. J. Clin. Endocrinol. Metab. 61:728, 1985.

    PubMed  CAS  Google Scholar 

  67. Jarret J.C., Ballejo G., Tsibris J.CM., Spellacy W.N. Insulin-binding to human ovaries. J. Clin. Endocrinol. Metab. 69:460, 1985.

    Google Scholar 

  68. Gates G.S., Bayer S., Seibel M., Poretsky L, Flier J.S., Moses A.C. Characterization of insulin-like-growth factor binding to human granulosa cells obtained during in vitro fertilization. J. Recept. Res. 7:885, 1987.

    PubMed  CAS  Google Scholar 

  69. Davoren J.B., Kasson B.J., Li C.H., Hsueh A.J.W. Specific insulin-like growth factor (IGF) I- and II-binding sites on rat granulosa cells; relation to IGF action. Endocrinology 119:2155, 1986.

    PubMed  CAS  Google Scholar 

  70. Adashi E.Y., Resnick C.E., D’ercole A.J., Svoboda M.E., Van Wyk J.J. Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr. Rev. 6:400, 1985.

    PubMed  CAS  Google Scholar 

  71. Veldhuis J.D., Kolp L.A., Toaff M.E., Strauss II J.F., Demers L.M. Mechanisms subserving the trophic actions of insulin on ovarian cells: in vitro studies using swine granulosa cells. J.Clin. Invest. 72:1046, 1983.

    PubMed Central  PubMed  CAS  Google Scholar 

  72. Savion N., Lui G.N., Laherty R., Gospodarowicz D. Factors controlling proliferation and progesterone production by bovine granulosa cells in serum-free medium. Endocrinology 709:409, 1981.

    Google Scholar 

  73. May J.V., Schonberg D.W. Granulosa cell differentiation in vitro: effect of insulinon growth and functional integrity. Biol. Reprod. 25:421, 1981.

    PubMed  CAS  Google Scholar 

  74. Maruo T., Hayashi M., Matsuo H., Ueda Y., Morikawa H., Mochizuki M. Comparison of the facilitative roles of insulin and insulin-like growth factor I in the functional differentiation of granulosa cells: in vitro studies with the porcine model. Acta Endocrinol. (Copenh.) 117:230, 1988.

    CAS  Google Scholar 

  75. Adashi E.Y., Resnick C.E., Rosenfeld R.G. Insulin-like growth factor-l (IGF-I) and IGF-II hormonal action in cultured rat granulosa cells: mediation via type I but not type II IGF receptors. Endocrinology 726:216, 1990.

    Google Scholar 

  76. Smith P., Wynford-Thomas D., Stringer M.J., Williams E.D. Growth factor control of rat thyroid follicular cell proliferation. Endocrinology 119:1439, 1986.

    PubMed  CAS  Google Scholar 

  77. Tramontano D., Cushing G.W., Moses A.C., Ingbar S.H. Insulin-like growth factor-l stimulates the growth of rat thyroid cells in culture and synergizes the stimulation of DNA synthesis induced by TSH and Graves’-lgG. Endocrinology 119: 940, 1986.

    PubMed  CAS  Google Scholar 

  78. Minuto F., Barreca A., Del Monte P., Cariola G., Torre G.C., Giordano G. Immunoreactive insulin-like growth factor I (IGF-I) and IGF-I binding protein content in human thyroid tissue. J. Clin. Endocrinbl. Metab. 6:621, 1989.

    Google Scholar 

  79. Minuto F., Barreca A., Ferrini S., Mazzocchi G., Del Monte P., Giordano G. Growth hormone secretion in pubertal and adult subjects. Acta Endocrinol. (Copenh.) 91:161, 1982.

    Google Scholar 

  80. Sheikholislam B.M., Stempfel Jr R.S. Hereditary isolated somatotropin deficiency: effects of human growth hormone administration. Pediatrics 49: 362, 1972.

    PubMed  CAS  Google Scholar 

  81. Swerdloff R.S., Odell W.D. Modulating influences of FSH, GH and prolactin on LH-stimulated testosterone secretion. In: Troen P., Nankin H. R. (Eds.), The testis in normal and infertile men. Raven Press, New York, 1977, p. 395.

    Google Scholar 

  82. Zipf W.B., Payne A.H., Kelch R.P. Prolactin, growth hormone and luteinizing hormone in the maintenance of testicular luteinizing hormone receptors. Endocrinology 103:595, 1978.

    PubMed  CAS  Google Scholar 

  83. Homburg R., Eshel A., Abdalla H.I., Jacobs H.S. Growth hormone facilitates ovulation induction by gonadotrophins. Clin. Endocrinol. 29:113, 1988.

    CAS  Google Scholar 

  84. Volpe A., Coukos G., Barreca A., Artini P.G., Minuto F., Giordano G., Genazzani A.R. Ovarian response to combined growth hormone-gonadotropin treatment in patients resistant to induction of superovulation. Gynecol. Endocrinol. 3:125, 1989.

    CAS  Google Scholar 

  85. Barreca A., Minuto F., Volpe A., Cecchelli E., Cella F., Del Monte P., Artini P., Giordano G. Insulin-like growth factor-l (IGF-I) and IGF-I binding protein in the follicular fluids of growth hormone treated patients. Clin. Endocrinol. 32:497, 1990.

    CAS  Google Scholar 

  86. Drop S.L.S., Valiquette G., Guyda H.J., Corvol M.T., Posner B.I. Partial purification and characterization of a binding protein for ILAs in human amniotic fluid: a possible inhibitor of insulin-like activity. Acta Endocrinol. 90:505, 1979.

    PubMed  CAS  Google Scholar 

  87. Chochinov R.H., Mariz I.K., Haiek A.S., Daughday W. Characterization of a protein in mid-term human amniotic fluid which reacts in the somatomedin-C radioreceptor assay. J. Clin. Endocrinol. Metab. 44:902, 1977.

    PubMed  CAS  Google Scholar 

  88. Povoa G., Enberg G., Jornvall H., Hall K. Isolation and characterization of a somatomedin-binding protein from midterm human amniotic fluid. Eur. J. Biochem. 744:199, 1984a.

    Google Scholar 

  89. Drop S.L.S., Kortleve D.J., Guyda H.J., Posner B.J. Immunoassay of a somatomedin-binding protein from human amniotic fluid: levels in fetal, neonatal and adult sera. J. Clin. Endocrinol. Metab. 59:908, 1984.

    PubMed  CAS  Google Scholar 

  90. Povoa G., Roovette A., Hall K. Cross-reaction of serum somatomedin-binding protein in a radioimmunoassay developed for somatomedin-binding protein isolated from human amniotic fluid. Acta Endocrinol. 707:563, 1984b.

    Google Scholar 

  91. Koistinen R., Kalkkinen N., Huhtala M.L., Seppala M., Bohn H., Rutanen E.M. Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid. Endocrinology 118:1375, 1986.

    PubMed  CAS  Google Scholar 

  92. Ritvos O., Ranta T., Jalkanen J., Suikkari A.M., Voutilainen R., Bohn H., Rutanen E.M. Insulin-like growth factor (IGF) binding protein from human decidua inhibits the binding and biological action of IGF-I in cultured choriocarcinoma cells. J. Clin. Endocrinol. Metab. 122:2150, 1988.

    CAS  Google Scholar 

  93. Elgin R.G., Busby W.H., Clemmons D.R. An insulin-like growth factor (IGF) binding protein enhances the biological response to IGF-I. Proc. Natl. Acad. Sci. USA 84: 3254, 1987.

    PubMed Central  PubMed  CAS  Google Scholar 

  94. Barreca A., Cecchelli E., Cariola G., Ferraro P., Cella F., Minuto F. Growth hormone binding activity in human serum and in other body fluids. J. Endocrinol. Invest. 75(Suppl. 1): 138, 1990.

    Google Scholar 

  95. Leung D.W., Spencer S.A., Cachianes G., Hammonds R.G., Collins C., Henzel W.J., Barnard R., Waters M.J., Wood W.I. Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature 330: 537, 1987.

    PubMed  CAS  Google Scholar 

  96. Daughday W.H., Trivedi B. Absence of serum growth hormone binding protein in patients with growth hormone receptor deficiency (Laron dwarfism). Proc. Natl. Acad. Sci. USA 84: 4636, 1987.

    Google Scholar 

  97. Zezulak K.M., Green H. The generation of insulin-like growth factor I sensitive cells by growth hormone action. Science 233: 551, 1986.

    PubMed  CAS  Google Scholar 

  98. Green H., Morikawa N., Nixon T. A dual effector theory of growth hormone action. Differentiation 29:195, 1985.

    PubMed  CAS  Google Scholar 

  99. Barreca A., Del Monte P., Artini P.G., Ferraro P., Cariola G., Volpe A., Genazzani A.R., Giordano G., Minuto F. Effect of growth hormone on estradiol and progesterone production by human granulosa cells. 73rd Annual Meeting of the Endocrine Society (USA), Washington DC, 19–22 June 1991.

  100. Clemmons D.R. Multiple hormones stimulates the production of somatomedin by cultured human fibroblasts. J. Clin. Endocrinol. Metab. 58:850, 1984.

    PubMed  CAS  Google Scholar 

  101. Geisthovel F., Moretti-Rojas I., Asch R.H., Rojas F.J. Expression of insulin-like growth factor-ll (IGF-II) messenger ribonucleic acid (mRNA), in human preovulatory granulosa cells. Hum. Reprod. 4:899, 1989.

    PubMed  CAS  Google Scholar 

  102. Cara J.F., Rosenfield R.L. Insulin-like growth factor I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells. Endocrinology 123:733, 1988.

    PubMed  CAS  Google Scholar 

  103. Hernandez E.R., Resnick C.E., Holtzclaw W.D., Payne D.W., Adashi E.Y. Insulin as a regulator of androgen biosynthesis by cultured rat ovarian cells: cellular mechanism(s) underlying physiological and pharmacological hormonal actions. Endocrinology 122:2034, 1988.

    PubMed  CAS  Google Scholar 

  104. Barbieri R.L., Makris A., Ryan K.J. Insulin stimulates androgen accumulation in incubations of human ovarian stroma and theca. Obstet. Gynecol. (Suppl.) 64: 73S, 1984.

  105. Barbieri R.L., Makris A., Randall R.W., Daniels G., Kistner R.W., Ryan K.J. Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from woman with hyperandrogenism. J. Clin. Endocrinol. Metab. 62:904, 1986.

    PubMed  CAS  Google Scholar 

  106. Erickson G.F., Magoffin D.A., Dyer C.A., Hofeditz C. The ovarian androgen producing cells: a review of structure/function relationships. Endocr. Rev. 6:371, 1985.

    PubMed  CAS  Google Scholar 

  107. Sommers S.C., Wadman P.J. Pathogenesis of polycystic ovaries. Am. J. Obstet. Gynecol. 72:160, 1956.

    PubMed  CAS  Google Scholar 

  108. Chang R.J., Nakamura R.M., Judd H.L., Katlan S.A. Insulin resistance in nonobese patient with polycystic ovarian disease. J. Clin. Endocrinol. Metab. 57:356, 1983.

    PubMed  CAS  Google Scholar 

  109. Shoupe D., Kumar D.D., Lobo R.A. Insulin resistance in polycystic ovary syndrome. Am. J. Obstet. Gynecol. 747:588, 1983.

    Google Scholar 

  110. Nagamani M., Dinh T.V., Kelver M.E. Hyperinsulinemia in hyperthecosis of the ovaries. Am. J. Obstet. Gynecol. 754:384, 1986.

    Google Scholar 

  111. Nagamani M., Hannigan E.V., Dinh T.V., Stuart C.A. Hyperinsulinemia and stromal luteinization of the ovaries in postmenopausal woman with endometrial cancer. J. Clin. Endocrinol. Metab. 67:144, 1988.

    PubMed  CAS  Google Scholar 

  112. Poretsky L, Bhargava G., Saketos M., Dunaif A. Regulation of human ovarian insulin receptors in vivo. Metabolism 39:161, 1990.

    PubMed  CAS  Google Scholar 

  113. Erickson G.F., Magoffin D.A., Cragun J.R., Chang R.J. The effects of insulin and insulin-like growth fac-tors-l and -II on estradiol production by granulosa cells of polycistic ovaries. J. Clin. Endocrinol. Metab. 76:894, 1990.

    Google Scholar 

  114. Dunaif A., Graf M., Mandeli J., Laumas V., Dobrjansky A. Characterization of groups of hyperandrogenic women with acanthosis nigricans impaired glucose tolerance and/or hyperinsulinemia. J. Clin. Endocrinol. Metab. 65: 499, 1987.

    PubMed  CAS  Google Scholar 

  115. Sharp P.S., Reed M.J., Johnston D.G., Franks S. The influence of insulin on androgen production and metabolism in the polycystic ovary syndrome. Programme of the British Diabetic Association, Medical and Scientific Section, Spring Meeting, Manchester, April 1989, Abstract P105.

  116. Plymate S.R., Matey L.A., Jones R.E., Friedl K.E. Inhibition of sex hormone binding-globulin production in the human hepatoma (HEP G2) cell line by insulin and prolactin. J. Clin. Endocrinol. Metab. 67:460, 1988.

    PubMed  CAS  Google Scholar 

  117. Kiddy D.S., Hamilton-Fairley D., Seppala M., Koistinen R., James V.H.T., Reed M.J., Franks S. Diet-induced changes in sex hormone binding globulin and free testosterone in women with nor mal or polycystic ovaries: correlation with serum insulin and insulin-like growth factor-l. Clin. Endocrinol. 31: 757, 1989.

    CAS  Google Scholar 

  118. Busby W.H., Snyder D.K., Clemmons D.R. Radioimmunoassay of a 26,000 Dalton plasma in sulin-like growth factor-binding protein; control by nutritional variables. J. Clin. Endocrinol. Metab. 67:1225, 1988.

    PubMed  CAS  Google Scholar 

  119. Suikkari A.M., Koivisto A., Koistinen R., Seppala M., Yki-Jarvinen H. Dose-response characteristics for suppression of low molecular weight plasma insulin-like growth factor binding-protein by insulin. J. Clin. Endocrinol. Metab. 68:135, 1989.

    PubMed  CAS  Google Scholar 

  120. Rutanen E.M., Pekonen F., Makinen T. Soluble 34 K binding protein inhibits the binding of insulin-like growth factor I to its cell receptors in human secretory phase endometrium: evidence for autocrine/paracrine regulation of growth fac tor action. J. Clin. Endocrinol. Metab. 66:173, 1988.

    PubMed  CAS  Google Scholar 

  121. Busby W.H., Hossenlopp P., Binoux M., Clemmons D.R. Purified preparations of the amniotic fluid-derived insulin-like growth factor-binding protein contain multimeric forms that are biologically active. Endocrinology 125:773, 1989.

    PubMed  CAS  Google Scholar 

  122. Suikkari A.M., Ruutiainen K., Erkolla R., Seppala M. Low levels of low molecular weight insulin-like growth factor-binding protein in women with polycystic ovarian disease. Hum. Reprod. 4:136, 1989.

    PubMed  CAS  Google Scholar 

  123. Lee D.C., Rose T.M., Webb N.R., Todaro G.J. Cloning and sequence analysis of cNA for rat transforming growth factor-alpha. Nature 313: 489, 1985.

    PubMed  CAS  Google Scholar 

  124. Skinner M.K., Lobb D., Dorrington J.H. Ovarian thecal interstitial cells produce an epidermal growth factor-like substance. Endocrinology 121:1892, 1987.

    PubMed  CAS  Google Scholar 

  125. Rail L.B.; Scott J., Bell G.I., Crawford R.J., Penschow J.D., Niall H.D., Cogclan J.P. Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues. Nature 313: 228, 1985.

    Google Scholar 

  126. Roy S.K, Greenwald G.S. Immunohistochemical localization of epidermal growth factor-like activity in the hamster ovary with a polyclonal antibody. Endocrinology 126:1309, 1990.

    PubMed  CAS  Google Scholar 

  127. Kudlow J.E., Kobrin M.S., Purchio A.F., Twardzik D.R., Hernandez E.R., Asa S.L., Adashi E.Y. Ovarian transforming growth factor-alpha gene expression: immunohistochemical localization to the theca-interstitial cells. Endocrinology 121:1577, 1987.

    PubMed  CAS  Google Scholar 

  128. Vlodavsky I., Brown K.D., Gospodarowicz D. A comparison of the binding of epidermal growth factor to cultured granulosa and luteal cells. J. Biol. Chem. 253:3744, 1978.

    PubMed  CAS  Google Scholar 

  129. Jones P.B.C., Welsh T.H., Hsueh A.J.W. Regulation of ovarian progestin production by epidermal growth factor in cultured rat granulosa cells. J. Biol. Chem. 257:11268, 1982.

    PubMed  CAS  Google Scholar 

  130. St. Arnaud R., Walker P., Kelly P.A., Labrie F. Rat ovarian epidermal growth factor receptors: characterization and hormonal regulation. Mol. Cell. Endocrinol. 31:43, 1983.

    PubMed  CAS  Google Scholar 

  131. Feng P., Knecht M., Catt K. Hormonal control of epidermal growth factor receptors by gonadotropins during granulosa cell differentiation. Endocrinology 120:1121, 1987.

    PubMed  CAS  Google Scholar 

  132. Buck P.A., Schomberg D.W. [125]iodo-epidermal growth factor binding and mitotic responsiveness of porcine granulosa cells are modulated by differentiation and follicle-stim ulating hormone. Endocrinology 122:28, 1988.

    PubMed  CAS  Google Scholar 

  133. May J.V., Buck P.A., Schomberg D.W. Epidermal growth factor enhances [125]iodo-fol-licle stimulating hormone (FSH) binding by cultured porcine granulosa cells. Endocrinology 120:2413, 1987.

    PubMed  CAS  Google Scholar 

  134. Gospodarowicz D., Mescher A.L., Birdwell C.R. Control of cellular proliferation by the fibroblast and epidermal growth factors. National Cancer Institute Monography 48: 109, 1978.

    Google Scholar 

  135. Gospodarowicz D., Bialecki H. Fibroblast and epidermal growth factors are mitogenic togenic agents for culture granulosa cells of rodent, porcine and human origin. Endocrinology 104:757, 1979.

    PubMed  CAS  Google Scholar 

  136. Hsueh A.J.W., Welsh T.H., Jones P.B.C. Inhibition of ovarian and testicular steroidogenesis by epidermal growth factor. Endocrinology 108:2002, 1981.

    PubMed  CAS  Google Scholar 

  137. Mondschein J.S., Schomberg D.W. Growth factors modulate gonadotropin receptor induction in granulosa cell cultures. Science 277:1179, 1981.

    Google Scholar 

  138. Trzeciak W.H., Duda T., Waterman M.R., Simpson E.R. Effects of epidermal growth factor on the synthesis of the cholesterol side-chain cleavage enzyme complex in rat ovarian granulosa cells in primary culture. Mol. Cell. Endocrinol. 52: 43, 1987.

    PubMed  CAS  Google Scholar 

  139. Dekel N., Sherizly I. Epidermal growth factor induces maturation of rat follicle-enclosed oocytes. Endocrinology 116: 406, 1985.

    PubMed  CAS  Google Scholar 

  140. Caubo B., DeVinna R.S., Tonetta S.A. Regulation of steroidogenesis in cultured porcine theca cells by growth factors. Endocrinology 125:321, 1989.

    PubMed  CAS  Google Scholar 

  141. Steinkampf M., Mendelson C, Simpson E. Effects of epidermal growth factor and insulin-like growth factor I on the levels of mRNA encoding aromatase cytochrome p-450 of human ovarian granulosa cells. Mol. Cell. Endocrinol. 59:93, 1988.

    PubMed  CAS  Google Scholar 

  142. Mason H.D., Margara R., Winston R.M.L., Beard R.W., Reed M.J., Franks S. Inhibition of oestradiol production by epidermal growth factor in human granulosa cells of normal and polycystic ovaries. Clin. Endocrinol. 33:511, 1990.

    CAS  Google Scholar 

  143. Richardson M.C., Gadd S.C., Masson G.M. Augmentation by epidermal growth factor of basal and stimulated progesterone production by hu man luteinized granulosa cells. J. Endocrinol. 131:397, 1989.

    Google Scholar 

  144. Roberts.B., Flanders K.C., Kondaiah P., Thompson N.L., VanObberghen-Schilling E., Wakefield L, Rossi P., De Crombrugghe B., Heine U., Sporn M.B. Transforming growth factor β: biochemistry and roles in embryogenesis, tissue repair and remodeling, and carcinogenesis. Recent Prog. Horm. Res. 44:157, ??

  145. Kretser D.M., Robertson D.M. The isolation and physiology of inhibin and related proteins. Biol. Reprod. 40:33, 1989.

    PubMed  Google Scholar 

  146. Bicsak T.A., Tucker E.M., Cappel S., Vaughan J., Rivier J., Vale W., Hsueh A.J.W. Hormonal regulation of granulosa cell inhibin biosynthesis. Endocrinology 779:2711, 1986.

    Google Scholar 

  147. Woodruff T.K., Meunier H., Jones P.B.C., Hseuh A.J.W., Mayo K.E. Rat inhibin: molecular cloning of alpha and β sub-unit complementary deoxyribonucleic acids and expression in the ovary. Mol. Endocrinol. 7:561, 1987.

    Google Scholar 

  148. Woodruff T.K., D’Agostino J., Schwartz N.B.. Mayo K. Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle. Science 239:1296, 1988.

    PubMed  CAS  Google Scholar 

  149. Hillier S.G., Wickings E.J., Saunders P.T.K., Dixson A.F., Shimasaki S., Swanston I.A., Reichert Jr. L.E., McNeilly A.S. Control of inhibin production by primate granulosa cells. J. Endocrinol. 723:65, 1989.

    Google Scholar 

  150. Hutchinson L.A., Findlay J.K., de Vos F.L., Robertson D.M. Effects of bovine inhibin, transforming growth fac-tor-β and bovine Activin-A on granulosa cell differentiation. Biochem. Biophys. Res. Commun. 146: 1405, 1987.

    PubMed  CAS  Google Scholar 

  151. Ying ST., Becker A., Ling N., Ueno N., Guillemin R. Inhibin and β type transforming growth factor (TGFβ) have opposite modulating effects on the follicle stimulating hormone (FSH)-induced aromatase activity of cultured rat granulosa cells. Biochem. Biophys. Res. Commun. 736: 969, 1986.

    Google Scholar 

  152. Zhang Z.W., Carson R.S., Herington A.C., Lee V.W., Burger H.G. Follicle-stimulating hormone and somatomedin-C stimulate inhibin production by rat granulosa cells in vitro. Endocrinology 720:1633, 1987.

    Google Scholar 

  153. Hsueh A.J.W., Dahl K.D., Vaughan J., Tucker E., Rivier J., Bardin C.W., Vale W. Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis. Proc. Natl. Acad. Sci. USA 84: 5082, 1987.

    PubMed Central  PubMed  CAS  Google Scholar 

  154. Hernandez E.R., Twardzik D.R., Purchio A., Adashi E.Y. Gonadotropin-dependent ovarian transforming growth factor-β gene expression. Biol. Reprod. 36: 58A, 1987.

    Google Scholar 

  155. Skinner M.K., Keski-Oja J., Oskeen K.G., Moses H.L. Ovarian thecal cells produce transforming growth factor β which can regulate granulosa cell growth. Endocrinology 727:786, 1987.

    Google Scholar 

  156. Bendell J.J., Dorrington J. Rat thecal/interstitial cells secrete a transforming growth factor-β-like factor that promotes growth and differentiation in rat granulosa cells. Endocrinology 123: 941, 1988.

    PubMed  CAS  Google Scholar 

  157. Thompson N.L., Flanders K.C., Smith J.M., Ellingsworth L.R., Roberts A.B., Sporn M.B. Expression of transforming growth factor-β 1 in specific cells and tissues of adult and neonatal mice. J. Cell. Biol. 108: 661, 1989.

    PubMed  CAS  Google Scholar 

  158. Mulheron G.W., Schomberg D.W. Rat granulosa cells express transforming growth factor-β type 2 mRNA which is regulatable by follicle-stimulating hormone in vitro. Endocrinology 126: 1777, 1990.

    PubMed  CAS  Google Scholar 

  159. Dorrington J., Chuma A.V., Bendell J.J. Transforming growth factor β and follicle-stimulating hormone promote rat granulosa cell proliferation. Endocrinology 123: 353, 1988.

    PubMed  CAS  Google Scholar 

  160. May J.V., Schomberg D.W. Synergistic action of epidermal growth factor β (TGFβ), and somatomedin-C (Sm C) on the initiation of DNA synthesis in porcine granulosa cells (pGC) maintained in defined medium. 69th Annual Meeting of the Endocrine Society, Indianapolis IN, Abstract 309, 1987.

    Google Scholar 

  161. Adashi E.Y., Resnick C.E. Antagonistic interactions of transforming growth factor in the regulation of granulosa cell differentiation. Endocrinology 119: 187, 1986.

    Google Scholar 

  162. Dahl K.D., Czekala N.M., Lim P., Hsueh A.J.W. Monitoring the menstrual cycle of humans and lowland gorillas based on urinary profiles of bioactive follicle-stimulating hormone and steroid metabolites. J. Clin. Endocrinol. Metab. 64: 486, 1987.

    PubMed  CAS  Google Scholar 

  163. Dodson W.C., Schomberg D.W. The effect of transforming growth factor-β on follicle stimulating hormone induced differentiation of cultured rat granulosa cells. Endocrinology 120: 512, 1987.

    PubMed  CAS  Google Scholar 

  164. Knecht M., Feng P., Catt K.J. Bifunctional role of transforming growth factor-β during granulosa cell development. Endocrinology 120: 1243, 1987.

    PubMed  CAS  Google Scholar 

  165. Zhang Z., Findlay J.K., Carson R.S., Herington A.C.H., Burger H.G. Transforming growth factor β enhances basal and FSH stimulated inhibin production by rat granulosa cells in vitro. Mol. Cell. Endocrinol. 58: 161, 1988.

    PubMed  CAS  Google Scholar 

  166. Feng P., Catt K.J., Knecht M. Transforming growth factor β regulates the in hibitory actions of epidermal growth factor during granulosa cell differentiation. J. Biol. Chem. 261: 14167, 1986.

    PubMed  CAS  Google Scholar 

  167. Magoffin D.A., Gancedo B., Erickson G.F. Transforming growth factor-β promotes differen tiation of ovarian thecal/interstitial cells but inhibits androgen production. Endocrinology 125: 1951, 1989.

    PubMed  CAS  Google Scholar 

  168. Tsafriri A., Vale W., Hsueh A.J.W. Effects of transforming growth factors and inhib-in-related proteins on rat preovulatory graafian follicles in vitro. Endocrinology 125: 1857, 1989.

    PubMed  CAS  Google Scholar 

  169. Feng P., Catt K.J., Knecht M. Transforming growth factor-β stimulates meiotic maturation of the rat oocyte. Endocrinology 122: 181, 1988.

    PubMed  CAS  Google Scholar 

  170. Baird A., Esch F., Mormede P., Ueno N., Ling N., Bohlen P., Ying S.-Y., Wehrenberg W.B., Guillemin R. Molecular characterization of fibroblast growth factor: distribution and biological activities in various tissues. Recent Prog. Horm. Res. 42: 1, 1986.

    CAS  Google Scholar 

  171. Gospodarowicz D., Ferrara N., Schweigerer L., Neufeld G. Structural characterization and biological functions of fibroblast growth factor. Endocr. Rev. 8: 95, 1987.

    PubMed  CAS  Google Scholar 

  172. Gimenez-Gallego G., Rodkey J., Bennet C., Rios-Candelore M., DiSalvo J., Thomas K. Brain-derived acidic fibroblast growth factor: complete amino acid sequence and homologies. Science 230: 1385, 1985.

    PubMed  CAS  Google Scholar 

  173. Neufeld G., Ferrara N., Schweigerer L, Mitchell R., Gospodarowicz. Bovine granulosa cells produce basic fibroblast growth factor. Endocrinology 121: 591, 1987.

    Google Scholar 

  174. Adashi E.Y., Resnick CE., Croft CS., May J.V., Gospadarowicz D. Basic fibroblast growth factor as a regulator of ovarian granulosa cell differentiation: a novel non-mitogenic role. Mol. Cell. Endocrinol. 122: 1383, 1988.

    CAS  Google Scholar 

  175. Gospodarowicz D., Cheng J., Lui G.M., Baird A., Esch F., Bohlen P. Corpus luteum angiogenic factor is related to fibroblast growth factor. Endocrinology 117: 2383, 1985.

    PubMed  CAS  Google Scholar 

  176. Gottschall P.E., Uehara A., Hoffmann S.T., Arimura A. Interleukin-I inhibits follicle stimulating hormone-induced differentiation in rat granulosa cells in vitro. Biochem. Biophys. Res. Commun. 149: 502, 1987.

    PubMed  CAS  Google Scholar 

  177. Beutler B., Cerami A. Cachectin (tumor necrosis factor): a macrophage hormone governing cellular metabolism and inflammatory response. Endocr. Rev. 9: 57, 1988.

    PubMed  CAS  Google Scholar 

  178. Roby K.F., Terranova P.F. Localization of tumor necrosis factor (TNF) in rat and bovine ovary using immunocytochemistry and cell blot: Evidence for granulosal production. In: Hirhfield A.N. (Eds.), Growth factors and the ovary. Plenum Press, New York, 1989, p. 273.

    Google Scholar 

  179. Roby K.F., Weed J., Lyies R., Terranova P.F. Immunological evidence for a human ovarian tumor necrosis factor-a. J. Clin. Endocrinol. Metab. 71: 1096. 1990.

    PubMed  CAS  Google Scholar 

  180. Emoto N., Baird A. The effect of tumor necrosis factor/cachectin on follicle stimulating hormone-induced aromatase activity in cultured rat granulosa cells. Biochem. Biophys. Res. Commun. 153: 792, 1988.

    PubMed  CAS  Google Scholar 

  181. Adashi E.Y., Resnick CE., Croft C.S., Payne D.W. Tumor necrosis factor a inhibits gonadotropin hor monal action in nontransformed ovarian granulosa cells. J. Biol.Chem. 264: 11591, 1989.

    PubMed  CAS  Google Scholar 

  182. Andreani C.L., Payne D.W., Packmann J.N., Resnick C.E., Hurwitz A., Adashi E.Y. Cytokine-mediated regulation of ovarian function. Tumor necrosis factor alpha inhibits gonadotropin-supported ovarian androgen biosyn thesis. J. Biol.Chem. 266: 2761, 1991.

    Google Scholar 

  183. Knecht M., Catt K.J. Modulation of cAMP-mediated differentiation in ovarian granulosa cells by epidermal growth factor and platelet-derived growth factor. J. Biol. Chem. 258: 2789, 1983.

    PubMed  CAS  Google Scholar 

  184. Mondschein J.S., Schomberg D.W. Platelet-derived growth factor enhances granulosa cell luteinizing hormone receptor induction by FSH and serum. Endocrinology 109: 320, 1981.

    Google Scholar 

  185. Mondschein J.S., Schomberg D.W. Effects of partially and more highly purified platelet-derived growth factor preparations on luteinizing hormone receptor induction in granulosa cell cultures. Biol. Reprod. 30: 603, 1984.

    PubMed  CAS  Google Scholar 

  186. Eden A.J., Jones J., Carter G.D., Alaghband-Zadeh J. A comparison of follicular fluid levels of insulinlike growth factor-l in normal dominant and cohort follicles, polycystic and multicystic ovaries. Clin. Endocrinol. 29: 327. 1988.

    CAS  Google Scholar 

  187. Ramasharma K., Cabrera CM., Li C.H. identification of insulin-like growth factor-ll in human seminal and follicular fluids. Biochem. Biophys. Res. Commun. 140: 536, 1986.

    PubMed  CAS  Google Scholar 

  188. Eden A.J., Jones J., Carter G.D., Alaghband-Zadeh J. Follicular fluid concentrations of insulin-like growth factor-l, epidermal growth factor, transforming growth factor-alpha and sex steroids in volume matched normal and polycystic human follicles. Clin. Endocrinol. 32: 395, 1990.

    CAS  Google Scholar 

  189. Weiss G., O’Byrne EM, Steinetz B.G. Relaxin: A product of the human corpus luteum of pregnancy. Science 194: 948, 1976.

    PubMed  CAS  Google Scholar 

  190. Yki-Jarvinen H., Wahistrom T., Seppala M. Immunohistochemical demonstration of relaxin in the genital tract of pregnant and nonpregnant women. J. Clin. Endocrinol. Metab. 57: 451, 1983.

    PubMed  CAS  Google Scholar 

  191. Vasilenko P., Mead J.P. Growth-promoting effects of relaxin and reiated compositional changes in the uterus, cervix and vagina of the rat. Endocrinology 120: 1370, 1987.

    PubMed  CAS  Google Scholar 

  192. Reich R., Mishin R., Tsafriri A. Intrafollicular distribution of plasminogen activators and their hormonal regulation in vitro. Endocrinology 119: 1588, 1986.

    PubMed  CAS  Google Scholar 

  193. Aten R.F., Polan M.L., Bayless R., Behrman H.R. A gonadotropin-releasing hormone (GnRH)-like protein in human ovaries: similarity to the GnRH- like ovarian protein of the rat. J. Clin. Endocrinol. Metab. 64: 1288, 1987.

    PubMed  CAS  Google Scholar 

  194. Li C.H., Ramasharma K., Yamashiro D.. Chung D. Gonadotropin-releasing peptide from human follicular fluid: isolation, characterization, and chem ical synthesis. Proc. Natl. Acad. Sci. USA 84: 959, 1987.

    PubMed Central  PubMed  CAS  Google Scholar 

  195. Petraglia F., Di Meo G., Storchi R., Segre A., Facchinetti F., Szalay S., Volpe A., Genazzani A.R. Proopiomelanocortin-related peptides and me thionine enkephalin in human follicular fluid: Changes during the menstrual cycle. Am. J. Obstet. Gynecol. 157: 142, 1987.

    PubMed  CAS  Google Scholar 

  196. Facchinetti F., Storchi A.R., Petraglia F., Volpe A., Genazzani A.R. Expression of proopiomelanocortin-relatea peptides in human follicular fluid. Peptides 9: 1089, 1988.

    PubMed  CAS  Google Scholar 

  197. Glorioso N., Atlas S.A., Laragh J.H., Jewelwicz R., Sealey J.E. Prorenin in high concentrations in human ovarian follicular fluid. Science 233: 1422, 1986.

    PubMed  CAS  Google Scholar 

  198. Do Y.S., Sherrod A., Lobo R.A., Paulson R.G., Shinagawa T., Chen S.W., Kjos S, Hsueh W.A. Human ovarian theca cells are a source of renin. Proc. Natl. Acad. Sci. USA 85: 1957. 1988

    PubMed Central  PubMed  CAS  Google Scholar 

  199. Fernandez L.A., Tarlatzis B.C., Rzasa P.J., Caride V.J., Laufer N., Negro-Vilar A.F., Decherney A.H.. Naftolin F. Renin-like activity in ovarian follicular fiuid. Fertil. Steril. 44: 219, 1985.

    PubMed  CAS  Google Scholar 

  200. Kim S.J., Shinjo M., Tada M., Fukamizu A., Miyazaki H., Usuki S., Murakami K. Ovarian renin gene expression is regulated by follicle stimulating hormone. Biochem. Biophys. Res. Commun. 142: 169, 1987.

    PubMed  CAS  Google Scholar 

  201. Lim A.T.W., Lolait S.J., Barlow D.J., Autelitano D.J., Toh B.H., Boublik J., Abraham J., Johnston C.I., Funder J.N. Immunoreactive arginine-vasopressin in brattle-boro rat ovary. Nature 310: 61, 1984.

    PubMed  CAS  Google Scholar 

  202. Kim S.H., Cho K.W., Seul K.H., Ryu H., Koh G.Y. Presence of immunoreactive atrial natriuretic peptide in follicular fluid, ovary and ovarian perfusates. Life Sci. 45: 1581, 1989.

    PubMed  CAS  Google Scholar 

  203. Olsson J.H., Akesson I., Hillesjo T. Effects of a gonadotropin-releasing hormone on progesterone formation in cultured human granulosa cells. Acta Endocrinol. (Copenh.) 4: 427, 1990.

    Google Scholar 

  204. Chen C. C-L., Chang C-C., Krieger D.T., Bardin C.W. Expression and regulation of proopiome-lanocortin-iike gene in the ovary and the placenta: comparison with the testis. Endocrinology 118: 2382, 1986.

    PubMed  CAS  Google Scholar 

  205. Meiner M.H., Young S.L., Czerwiec F.S., Lyn D., Puett D., Roberts J.L., Koos R.D. The regulation of granulosa cell proopiomelanocortin messenger ribonucleic acid by androgens and gonadotropins. Endocrinology 119: 2082, 1986.

    Google Scholar 

  206. Facchinetti F., Ruspa M., Turci A., Petraglia F., Segre A., Forabosco A., Genazzani A.R. Met-enkephalin enhances FSH-dependent proges terone production from cultured granulosa cells. J. Endocrinol. Metab. 63: 1222, 1986.

    CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Giordano, G., Barreca, A. & Minuto, F. Growth factors in the ovary. J Endocrinol Invest 15, 689–707 (1992). https://doi.org/10.1007/BF03345818

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03345818

Key-words

  • Growth factors
  • insulin-like
  • somatomedin
  • binding protein
  • inhibin
  • prostaglandins
  • interleukin
  • ovary
  • granulosa
  • theca
  • gonads
  • endorphins
  • vasopressin
  • LHRH
  • TNF-alpha