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Hexarelin: A multi-receptor peptide

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References

  1. Deghenghi R, Cananzi MM, Torsello A, Battisti C, Muller EE, Locatelli V. GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats. Life Sci 1994, 54: 1321–8.

    Article  PubMed  CAS  Google Scholar 

  2. Kaisary AV, Bowsher WG, Gillatt DA, Anderson JB, Malone PR, Imbimbo BP. Pharmacodynamics of a long acting depot preparation of avorelin in patients with prostate cancer. Avorelin Study Group. J Urol 1999, 162: 2019–23.

    Article  PubMed  CAS  Google Scholar 

  3. Maghnie M, Spica-Russotto V, Cappa M, et al. The growth hormone response to hexarelin in patients with different hypothalamic-pituitary abnormalities. J Clin Endocrinol Metab 1998, 83: 3886–9.

    Article  PubMed  CAS  Google Scholar 

  4. Tolis G, Karydis I, Markousis V, et al. Growth hormone release by the novel GH releasing peptide hexarelin in patients with homozygous beta-thalassemia. J Pediatr Endocrinol Metab 1997, 10: 35–40.

    PubMed  CAS  Google Scholar 

  5. Gasperi M, Aimaretti G, Scarcello G, et al. Low dose hexarelin and GHRH as a diagnostic tool for GH deficiency in adults: comparison with insulin-induced hypoglycemia test. J Clin Endocrinol Metab 1999, 84: 2633–7.

    PubMed  CAS  Google Scholar 

  6. Korbonits M, Kaltsas G, Perry LA, et al. Hexarelin as a test of pituitary reserve in patients with pituitary disease. Clin Endocrinol (Oxf) 1999, 51: 369–75.

    Article  CAS  Google Scholar 

  7. Laron Z, Frenkel J, Deghenghi R, Anin S, Klinger B, Silbergeld A. Intranasal administration of the GHRP hexarelin accelerates growth in short children. Clin Endocrinol (Oxf) 1995, 43: 631–5.

    Article  CAS  Google Scholar 

  8. Patchett AA, Nargund RP, Tata JR, et al. Design and biological activities of L-163,191 (MK 0677): a potent, orally active growth hormone secretagogue. Proc Natl Acad Sci USA 1995, 92: 7001–5.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  9. Pong SS, Chaung LY, Dean DC, Nargund RP, Patchett AA, Smith RG. Identification of a new G-protein-linked receptor for GHS. Mol Endocrinol 1996, 10: 57–61.

    PubMed  CAS  Google Scholar 

  10. Papotti M, Ghè C, Cassoni P, Catapano F, et al. Growth hormone secretagogues binding sites in peripheral human tissues. J Clin Endorinol Metab 2000, 85: 3803–7.

    CAS  Google Scholar 

  11. De Gennaro Colonna V, Rossoni G, Bernareggi M, Müller EE, Berti F. Cardiac ischemia and impairment of vascular endothelium function in hearts from GH-deficient rats: protection by hexarelin. Eur J Pharmacol 1997, 334: 201–7.

    Article  PubMed  Google Scholar 

  12. Locatelli V, Rossoni G, Schweiger F, et al. Growth hormone-independent cardioprotective effects of hexarelin in the rat. Endocrinology 1999, 140: 4024–31.

    PubMed  CAS  Google Scholar 

  13. Tivesten A, Bollano E, Caidahl K, Bengtsson BA, Isgaard J. The growth hormone secretagogue hexarelin improves cardiac function in rats after experimental myocardial infarction. Endocrinology 2000, 141: 60–6.

    PubMed  CAS  Google Scholar 

  14. Filigheddu N, Fubini A, Baldanzi G, et al. Hexarelin protects H9c2 cardiomyocytes from doxorubicin-induced cell-death. Endocrine 2001, 14: 113–9.

    Article  PubMed  CAS  Google Scholar 

  15. Pang JJ, Xu RK, Xu XB, et al. Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro. Am J Physiol Heart Circ Physiol 2004, 286: H1063–9.

    Article  PubMed  CAS  Google Scholar 

  16. Bodart V, Febbraio M, Demers A, et al. CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart. Circ Res 2002, 90: 844–9.

    Article  PubMed  CAS  Google Scholar 

  17. Rodrigue-Way A, Demers A, Ong H, Tremblay A. A growth hormone-releasing peptide promotes mitochondrial biogenesis and a fat burning-like phenotype through scavenger receptor CD36 in white adipocytes. Endocrinology 2007, 148: 1009–18.

    Article  PubMed  CAS  Google Scholar 

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Deghenghi, R. Hexarelin: A multi-receptor peptide. J Endocrinol Invest 31, 680 (2008). https://doi.org/10.1007/BF03345625

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