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Absence of allelic imbalance involving EMSY, CAPN5, and PAK1 genes in papillary thyroid carcinoma

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Abstract

Papillary thyroid cancer (PTC) accounts for 80% of all thyroid malignancies, and genetic alterations associated to its etiology remain largely unknown. Chromosomal band 11q13 seems to be one of the most frequently amplified regions in human cancer, providing several candidate genes that need detailed characterization. The aim of our study was to investigate the existence of allelic imbalance at EMSY, CAPN5, and PAK1, as candidate genes within 11q13.5-q14 region using a single nucleotide polymorphism-based analysis. We selected a panel of 9 polymorphisms that were analyzed in 41 thyroid carcinoma samples, their contralateral non-pathological tissue and 178 controls from the general population. We did not detect allelic imbalance at these loci in our series. However, we observed a difference in the EMSY-haplotype distribution among PTC patients when compared to controls (odds ratio=2.00; p=0.02). We conclude that 11q13.5-q14 is not imbalanced in PTC, but there is evidence suggesting that EMSY might be of relevance in PTC etiology.

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Authors and Affiliations

  1. Department of Surgery, Hospital Doce de Octubre, Madrid

    M. Hidalgo, E. Ferrero-Herrero & M. Labalde-Martinez

  2. Departamento de Genómics Estructural, Neocodex, Avda Charles Darwin, s/n, Isla de la Cartuja, 41092, Sevilla, Spain

    M. E. Saez, F. J. Moron, A. Ruiz, J. L. Royo PhD & R. Ramirez-Lorca PhD

  3. Department of Anatomopathology, Hospital Doce de Octubre, Madrid

    F. J. Martinez-Tello & C. Ballestin-Carcavilla

  4. Department of Internal Medicine, Endocrinology Service, Hospital Doce de Octubre, Madrid, Spain

    D. Rigopoulou

Authors
  1. M. Hidalgo
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  2. M. E. Saez
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  3. F. J. Martinez-Tello
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  4. F. J. Moron
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  5. E. Ferrero-Herrero
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  6. M. Labalde-Martinez
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  7. D. Rigopoulou
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  8. C. Ballestin-Carcavilla
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  9. A. Ruiz
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  10. J. L. Royo PhD
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  11. R. Ramirez-Lorca PhD
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Correspondence to J. L. Royo PhD.

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Hidalgo, M., Saez, M.E., Martinez-Tello, F.J. et al. Absence of allelic imbalance involving EMSY, CAPN5, and PAK1 genes in papillary thyroid carcinoma. J Endocrinol Invest 31, 618–623 (2008). https://doi.org/10.1007/BF03345613

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  • DOI: https://doi.org/10.1007/BF03345613

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