Abstract
Up to 21% of severe cases of malaria tropica are associated with polyuria and are life-threatening. We describe a 39-yr-old man with malaria tropica who developed disseminated intravascular coagulation, polyuria, and a pituitary lesion. Empiric treatment with vasopressin improved the polyuria. This is the first case of malaria tropica in which central diabetes insipidus has been documented. (J. Endocrinol. Invest. 29: 265–266, 2006)
Similar content being viewed by others
References
Grimwade K, French N, Mthembu D, Gilks C. Polyuria in association with Plasmodium falciparum malaria in a region of unstable transmission. Trans R Soc Trop Med Hyg 2004, 98: 255–60.
Davis TM, Li TA, Tran QB, et al. The hypothalamic-pituitary-adrenocortical axis in severe falciparum malaria: effects of cytokines. J Clin Endocrinol Metab 1997, 82: 3029–33.
Ustianowski A, Schwab U, Pasvol G. Severe acute symptomatic hyponatremia in falciparum malaria. Trans R SocTrop Med Hyg 2002, 96: 647–8.
Elster AD. Modern imaging of the pituitary. Radiology 1993, 187: 1–14.
Bonnevillle F, Narboux Y, Cattin F, Rodiere E, Jacquet G, Bonneville JF. Preoperative location of the pituitary bright spot in patients with pituitary macroadenomas. AJNR Am J Neuroradiol 2002, 23: 528–32.
Skordis N, Patsalis PC, Hettinger JA, et al. A novel arginine vasopressin-neurophysin II mutation causes autosomal dominant neurohypophyseal diabetes insipidus and morphologic pituitary changes. Horm Res 2000, 53: 239–45.
Maghnie M, Villa A, Arico M, et al. Correlation between magnetic resonance imaging of posterior pituitary and neurohypophyseal function in children with diabetes insipidus. J Clin Endocrinol Metab 1992, 74: 795–800.
Lee MH, Choi HY, Sung YA, Lee JK. High signal intensity of the posterior pituitary gland on T1-weighted MR images. Correlation with plasma vasopressin concentration to water deprivation. Acta Radiol 2001, 42: 129–34.
Fujisawa I, Murakami N, Furuto-Kato S, Araki N, Konishi J. Plasma and neurohypophyseal content of vasopressin in diabetes mellitus. J Clin Endocrinol Metab 1996, 81: 2805–9.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Schubert, S., Achenbach, H., Engelmann, L. et al. Central diabetes insipidus in a patient with malaria tropica. J Endocrinol Invest 29, 265–266 (2006). https://doi.org/10.1007/BF03345552
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03345552