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Autoimmune thyroiditis in non-obese subjects with initial diagnosis of Type 2 diabetes mellitus

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Abstract

Autoimmune thyroiditis is often associated with Type 1 diabetes mellitus (T1DM). In non-obese adult-onset diabetes diagnosed initially as Type 2 diabetes mellitus (T2DM), there is a proportion of cases with so far undiagnosed T1DM. The objective of this study was to estimate the frequency of autoimmune thyroiditis (AT) among non-obese (BMI <30.0 kg/m2) patients with T2DM and to compare the frequency of AT in subgroups of patients according to the presence of glutamic acid decarboxylase antibodies (GADA), insulin requirement, and post-breakfast C-peptide levels. The study included 118 adult patients (55 men and 63 women) with the initial diagnosis of T2DM and age at the onset of diabetes >35 yr. Median of age was 66 yr (range 39-82), and median duration of diabetes was 9 (range 1-27) yr. AT was diagnosed using thyroid peroxidase antibodies, TG-antibodies, US and TSH levels. Nineteen per cent of the subjects were found to have AT, and the frequency of AT did not significantly differ between the groups of GADA+ and GADA- subjects. There was no difference in the frequency of AT between the group treated with hypoglycemic agents and/or diet and the group requiring insulin. The frequency of AT was higher in the group with post-breakfast C-peptide levels ≤0.8 nmol/l compared to the group with post-breakfast C-peptide levels >0.8 nmol/l (37% vs 16%), however the group with post-breakfast C-peptide levels ≤0.8 nmol/l had longer duration of diabetes.

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Authors and Affiliations

  1. Institute of Endocrinology, Národní 8, 116 94, Prague, Czech Republic

    M. Matějková-Běhanová, V. Zamrazil, K. Vondra, J. Vrbíková & M. Hill

  2. Department of Allergology and Immunology, Czech Republic

    P. Kučera

  3. Diabetes Centre, 3rd Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic

    M. Anděl

Authors
  1. M. Matějková-Běhanová
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  2. V. Zamrazil
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  3. K. Vondra
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  4. J. Vrbíková
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  5. P. Kučera
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  6. M. Hill
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  7. M. Anděl
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Correspondence to M. Matějková-Běhanová.

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Matějková-Běhanová, M., Zamrazil, V., Vondra, K. et al. Autoimmune thyroiditis in non-obese subjects with initial diagnosis of Type 2 diabetes mellitus. J Endocrinol Invest 25, 779–784 (2002). https://doi.org/10.1007/BF03345512

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