Abstract
A 44-year-old man with atrial fibrillation caused by hyperthyroidism is described. The underlying disease was a TSH-secreting macroadenoma of the pituitary. Treatment with the somatostatin analog octreotide eliminated hyperthyroidism and atrial fibrillation within 4 days and the tumor size diminished substantially within 3 weeks.
Similar content being viewed by others
References
Beck-Peccoz P., Brucker-Davis F., Persani L., Smallridge R.C., Weintraub B.D. Thyrotropin-secreting pituitary tumors. Endocr. Rev. 17: 610, 1996.
Smallridge R.C., Smith C.E. Hyperthyroidism due to thyrotropin-secreting pituitary tumors: diagnostic and therapeutic considerations. Arch. Intern. Med. 143: 503, 1983.
Bruns C., Weckbecker G., Raulf F., Lubhert H., Hoyer D. Characterization of somatostatin receptor subtypes. Ciba Foundation Symposium 190: 89, 1995.
Srikant C.B. Cell cycle dependent induction of apoptosis by so-matostatin analog SMS 201–995 in AtT-20 mouse pituitary cells. Biochem. Biophys. Res. Commun. 209: 400, 1995.
Chayen S.D., Gross D., Makhoul O., Glaser B. TSH-producing pituitary tumor: Biochemical diagnosis and long-term medical management with oc-treotide. Horm. Metab. Res. 24: 34, 1992.
Chason Ph., Weintraub B.D., Harris A.G. Octreotide therapy for thyroid-stimulating hormone-secreting pituitary adenomas. Ann. Intern. Med. 119: 236, 1993.
Losa M., Giovanelli M., Persani L., Mortini P., Faglia G., Beck-Peccoz P. Criteria of cure and follow-up of central hyperthy-roidism due to thyrotropin-secreting pituitary adenomas. J. Clin. Endocrinol. Metab. 81: 3084, 1996.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fischler, M.P., Reinhart, W.H. TSH-secreting pituitary macroadenoma: Rapid tumor shrinkage and recovery from hyperthyroidism with octreotide. J Endocrinol Invest 22, 64–65 (1999). https://doi.org/10.1007/BF03345480
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03345480