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Role of candidate genes in the lipid responses to intensified treatment in Type 2 diabetes

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Abstract

Objective: To identify genetic factors related to individual differences in lipid responses to intensified treatment in Type 2 diabetes. Design and Methods: After evaluation and intensification of their treatment, 107 Type 2 diabetes patients with poor metabolic control were re-evaluated after mean follow-up time of 15.6 (0, 4) (SE) months. The genes coding major lipid regulatory proteins and their relations to plasma lipid and lipoprotein changes were studied. Results: During the follow- up, levels of glycohemoglobin A1 (GHBA1) decreased (−1.7%), plasma HDL cholesterol (+0.05 mmol/l) and lipoprotein (a) [Lp(a)] (+4.2 mg/dl) increased, while triglyceride (TG) levels decreased (−1.2mmol/l) despite mean weight gain of 2.1 kg (p from <0.01 to <0.001). Of the gene markers studied, the lipoprotein lipase (LPL) PvuII (p=0.005) independently affected changes in HDL-cholesterol and was associated with the frequency of coronary heart disease (CHD). Lp(a) changes were associated with apolipoprotein B (ApoB) Glu4154Lys polymorphism (p=0.004). Conclusions: These results suggest that genetic variations at LPL and ApoB loci are among the factors contributing to the variability in response to lipid parameters to therapy in Type 2 diabetes. LPL PvuII rare allele homozygote status seems to be beneficial with more favorable lipid changes and protection against CHD.

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Authors and Affiliations

  1. Department of Internal Medicine and Biocenter Oulu, University of Oulu, P.O. Box 5000, Oulu, FIN-90014, Finland, Europe

    O. Ukkola MD, PhD (Docent in Internal medicine, Specialist in Internal medicine and Endocrinology), J. Salonen & Y. Antero Kesäniemi

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  1. O. Ukkola MD, PhD
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  2. J. Salonen
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  3. Y. Antero Kesäniemi
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Correspondence to O. Ukkola MD, PhD.

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Ukkola, O., Salonen, J. & Kesäniemi, Y.A. Role of candidate genes in the lipid responses to intensified treatment in Type 2 diabetes. J Endocrinol Invest 28, 871–875 (2005). https://doi.org/10.1007/BF03345317

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