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Growth-hormone response to combined stimulation with GHRH plus GH-releasing peptide-6 in obese patients with polycystic ovary syndrome before and after short-term fasting

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Abstract

Controversial data were reported on GH response to different provocative stimuli in obese patients with polycystic ovary syndrome (PCOS). The objective of our study was to assess the effect of short-term fasting on GH response to combined stimulus with GHRH+GH-releasing peptide-6 (GHRP-6) in obese patients with PCOS and possible relation with leptin and insulin changes during fasting. Twelve obese PCOS women and nine obese control women participated in 3-day fasting. GH response, IGF-I, insulin and leptin were measured after GHRH+ GHRP-6, before and after short-term fasting. Obese PCOS patients had significantly greater GH peak after GHRH+GHRP-6 before fasting. Enhanced response to GH stimulation was found after fasting without substantial differences between obese PCOS and obese controls. Insulin and leptin significantly decreased, while insulin sensitivity significantly improved in both groups during fasting. In conclusion, obese PCOS patients have peculiar type of GH response to GHRH+GHRP-6 before fasting, possibly due to enhanced sensitivity of somatotrophs. Observed changes in insulin and leptin may participate in modulation of enhanced GH response after short-term fasting to GHRH+GHRP-6 in PCOS and obese controls.

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Authors and Affiliations

  1. Institute of Endocrinology, Diabetes and Diseases of Metabolism, Dr Subotica 13, 11000, Beograd, Yugoslavia

    Dragan Micić*, M. Šumarac-Dumanović, Dj. Macut, A. Kendereški, S. Zorič, V. Popović & G. Cvijović

  2. Department of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain

    C. Dieguez & F. F. Casanueva

Authors
  1. Dragan Micić*
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  2. M. Šumarac-Dumanović
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  3. Dj. Macut
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  4. A. Kendereški
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  5. S. Zorič
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  6. V. Popović
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  7. G. Cvijović
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  8. C. Dieguez
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  9. F. F. Casanueva
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Correspondence to Dragan Micić*.

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Micić*, D., Šumarac-Dumanović, M., Macut, D. et al. Growth-hormone response to combined stimulation with GHRH plus GH-releasing peptide-6 in obese patients with polycystic ovary syndrome before and after short-term fasting. J Endocrinol Invest 26, 333–340 (2003). https://doi.org/10.1007/BF03345181

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