Skip to main content
Log in

Diffuse sclerosing variant of papillary thyroid carcinoma with primary squamous cell carcinoma

  • Case Report
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

A case of a very rare combination of diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) and primary squamous thyroid carcinoma (PSC) is presented. A 25-yr-old woman with right-sided neck mass and hypothyroidism was admitted. US showed that the right lobe of the thyroid gland was enlarged with irregular margins and heterogen echogenity and there were multiple small punctate echogenic foci in the central portion. A scintigraphy with 99mTc showed decreased uptake in the right lobe. FNA of the right lobe induced us to consider the presence of follicular neoplasm. Chest roentgenogram was normal. Total thyroidectomy with right-sided modified radical neck dissection was performed. Findings related to Hashimoto’s thyroiditis and abundant psammoma bodies were observed in the frozen sections. Histopathologic findings demonstrated the coexistence of DSPC and PSC in both lobes and 16 lymph nodes metastases and soft tissue infiltration. Radioiodine was administered to ablate residual thyroid tissue. She was given T4 suppression therapy. At the 44th month of follow-up, she remains well without recurrences and metastases. The coexistence of DSPC and thyroiditis or PSC is still under debate. Very few cases with the combination of papillary thyroid carcinoma and PSC have been reported previously, thus we discuss the clinico-pathologic features and possible explanation for this unusual coexistence of malignancies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Hefer T., Joachims H.Z., Eitan A., Munichor M. Are the morphology of papillary thyroid carcinoma and the tumour’s behaviour correlated? J. Laryngol. Otol. 1996, 110: 704–705.

    Article  PubMed  CAS  Google Scholar 

  2. Damiani S., Dina R., Eusebi V. Cytologic grading of aggressive and nonaggressive variants of papillary thyroid carcinoma. Am. J. Clin. Pathol. 1994, 101: 651–655.

    PubMed  CAS  Google Scholar 

  3. Vickery A.L., Carcangiu M.L., Johannessen J.V. Papillary carcinoma. Session I of thyroid tumor pathology. Semin. Diagn. Pathol. 1985, 2: 90–100.

    PubMed  Google Scholar 

  4. Soares J., Limbert E., Sobrinho-Simoes M. Diffuse sclerosing variant of papillary thyroid carcinoma. A clinicopathologic study of 10 cases. Path. Res. Pract.1989, 185: 200–206.

    Article  PubMed  CAS  Google Scholar 

  5. Burman K.D., Ringel M.D., Wartofsky L. Unusual types of thyroid neoplasms. Squamous cell carcinoma. Endocrinol. Metab. Clin. North Am. 1996, 25: 56–59.

    Google Scholar 

  6. Carcangiu M.L., Bianchi S. Diffuse sclerosing variant of papillary thyroid carcinoma. Clinicopathologic study of 15 cases. Am. J. Surg. Pathol. 1989, 13: 1041–1049.

    Article  PubMed  CAS  Google Scholar 

  7. Livolsi V.A. Pathology of thyroid disease. In: Braverman L.E., Utiger R.D. (Eds.), Werner & Ingbar’s Thyroid: A fundamental and clinical text, ed. 8. Lippincott Williams & Wilkins, Philadelphia, 2000, p. 497.

    Google Scholar 

  8. Thyroid gland. In: Rosai J. (Ed.), Ackerman’s Surgical Pathology, ed. 8. Mosby-Year Book, Inc., St. Louis, 1996, vol. 1, p. 522.

  9. Carcangiu M.L., De Lellis R.A. Thyroid gland. In: Damjanov I., Linder J. (Eds.), Anderson’s Pathology, ed. 10. Mosby-Year Book, Inc., St. Louis, 1996, vol. 2, p. 1961.

    Google Scholar 

  10. Leung C., Hartwick R.W.J., Bedard Y.C. Correlation of cytologic and histologic features in variants of papillary carcinoma of the thyroid. Acta Cytol. 1993, 37: 645–650.

    PubMed  CAS  Google Scholar 

  11. Kumar P., Malekhusseini S., Talei A. Primary squamous cell carcinoma of the thyroid diagnosed by fine needle aspiration cytology. A report of two cases. Acta Cytol. 1999, 43: 659–662.

    Article  PubMed  CAS  Google Scholar 

  12. Kleer C., Giordano T., Merino M. Squamous cell carcinoma of the thyroid: an aggressive tumor associated with tall cell variant of papillary thyroid carcinoma. Mod. Pathol. 2000, 13: 742–746.

    Article  PubMed  CAS  Google Scholar 

  13. Albareda M., Puig-Domingo M., Wengrowicz S. Clinical forms of presentation and evaluation of diffuse sclerosing variant of papillary carcinoma and insular variant of follicular carcinoma of the thyroid. Thyroid 1998, 8: 385–391.

    Article  PubMed  CAS  Google Scholar 

  14. Hayashi Y., Sasao T., Takeichi N. Diffuse sclerosing variant of papillary carcinoma of the thyroid. A histopathological study of four cases. Acta Pathol. Jpn. 1990, 40: 193–198.

    PubMed  CAS  Google Scholar 

  15. Sagan C., Fiche M., Cuilliere P., Leborgne J. Carcinome papillaire sclerosant diffus de la thyroide. Presentation d’un cas. Ann. Pathol. 1993, 13: 256–259.

    PubMed  CAS  Google Scholar 

  16. Moreno Egea A., Rodriguez Gonzalez J.M., Sola Perez J., Soria T., Parrilla Paricio P. Clinicopathological study of the diffuse sclerosing variety of papillary cancer of the thyroid. Presentation of 4 new cases and review of the literature. Eur. J. Surg. Oncol. 1994, 20: 7–11.

    Google Scholar 

  17. Schröder S., Bay V., Dumke K. Diffuse sclerosing variant of papillary thyroid carcinoma. S-100 protein immunochemistry and prognosis. A case report. Virchows Arch. 1990, 416: 367–371.

    Article  Google Scholar 

  18. Harada T., Shimaoka K., Yakumaru K. Squamous cell carcinoma of the thyroid gland-transition from adenocarcinoma. J. Surg. Oncol. 1982, 19: 36–43.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to N. Kebapci.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kebapci, N., Efe, B., Kabukcuoglu, S. et al. Diffuse sclerosing variant of papillary thyroid carcinoma with primary squamous cell carcinoma. J Endocrinol Invest 25, 730–734 (2002). https://doi.org/10.1007/BF03345109

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03345109

Key-words

Navigation