Abstract
To investigate the possible major source of thyroid autoantibodies production, blood samples were obtained from thyroid vein, jugular vein and peripheral vein during subtotal thyroidectomy in 12 patients with Graves’ disease (11F, 1M; age 16–39 yr). Among them, 7 were treated preoperatively by methimazole, 4 by iopanoic acid and 1 by propranolol. All blood samples were assayed for thyroglobulin (Tg), thyrotropin binding inhibition immunoglobulin (TBII), antithyroglobulin antibody (TgAb) and antimicrosomal antibody (McAb). Tg, a native product of thyroid gland, was markedly elevated in the thyroid veins, over 4 to 6 folds that of jugular veins or peripheral veins. However, the level of thyroid autoantibodies including TBII, TgAb and McAb in the thyroid veins were not significantly different from that in the jugular or peripheral veins. Our preliminary data suggest that it is thyroglobulin, and not thyroid antibodies that is present at higher level in the thyroid vein than the periphery.
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Pinchera A., Liberti P., Martino E., Fenzi G.F., Grasso L., Rovis L., Baschieri L., Doria G. Effects of antithyroid therapy on the long-acting thyroid stimulator and the antithyroglobulin antidodies. J. Clin. Endocrinol. Metab. 29: 231, 1969.
Kendall-Taylor P., Knox A.J., Steel N.R., Atkinson S. Evidence that thyroid stimulating antibody is produced in the thyroid gland. Lancet 7: 654, 1984.
Arqueros M.D.C., Niepomniszcze H., Moreno J. Thyroid glands in patients with Graves’ disease are sources of thyrotropin binding inhibitory (TBI) activity. Acta Endocrinol. (Copenh.) 772: 351, 1986.
Wilson R., McKillop J.H., Pearson C, Burnett A.K., Gunn I., McNicol A.M., Thomson J.A. Absence of gradient of thyrotropin receptor antibody and T cell subset distribution between thyroid and peripheral venous blood in patients with Graves’ disease prepared for surgery with Carbimazole and potassium iodide. Clin. Exp. Immunol. 73: 265, 1988.
Sugenoya A., Kobayashi S., Kasuga Y., Masuda H., Fujimori M., Komatsu M., Takahashi S., Yokoyama S., Shimizu T., Yamada T., Iida F. Evidence of intrathyroidal accumulation of TSH receptor antibody in Graves’ disease. Acta. Endocrinol. (Copenh.) 126: 416, 1992.
Weetman A.P., Yateman M.E., Ealey P.A., Black C.M., Reimer C.B., Williams R.C., Shine B., Marshall J. Thyroid-stimulating antibody activity between different immunoglobulin G subclasses. J. Clin. Invest. 86: 723, 1990.
Parkes A.B., McLachlan S.M., Bird P., Rees Smith B. The distribution of microsomal and thyroglobulin antibody acitvity among the IgG subclasses. Clin. Exp. Immunol. 57: 239, 1984.
Weetman A.P., Black C.M., Cohen S.B., Tomlinson R., Banga J.P., Reimer C.B. Affinity purification of Ig G subclasses and the distribution of thyroid auto-antibody reactivity in Hashmoto’s thyroiditis. Scand. J. Immunol. 30: 73, 1989.
Lachmann P.J., Peters D.K. The immunoglobulins. In: Kunkel H.G. (Ed.), Clinical Aspects of Immunology ed. 4. Blackwell Scientific Publication, Oxford, 1982, p. 3.
McLachlan S.M., McGregor, A., Rees Smith B., Hall R. Thyroid-autoantibody synthesis by Hashimoto thyroid lymphocytes. Lancet 1: 162, 1979.
MaLachlan S.M., Dickinson A.M., Malcolm A., Farndon J.R., Young E., Proctor S.J., Rees Smith B. Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. I. Lymphocyte markers and response to pokeweed mitrogen. Clin. Exp. Immunol. 52: 45, 1983.
Weetman A.P., McGregor A.M., Lazarus J.H., Hall R. Thyroid antibodies are produced by thyroid-derived lymphocytes. Clin. Exp. Immunol. 48: 196, 1982.
McLachlan S.M., Pegg C.A.S., Atherton M.C., Middleton S.L., Clark F., Rees Smith B. TSH receptor antibody synthesis by thyroid lymphocytes. Clin. Endocrinol. (Oxf.) 24: 223, 1986.
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Chou, FF., Wang, PW. & Sheen-Chen, SM. The presence of higher levels of thyroglobulin, but not thyroid autoantibodies, in the thyroid vein in Graves’ disease. J Endocrinol Invest 17, 41–44 (1994). https://doi.org/10.1007/BF03344961
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DOI: https://doi.org/10.1007/BF03344961