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Pubertà precoce: quando e come trattare

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In questo articolo vengono analizzati gli aspetti fondamentali della diagnosi della pubertà precoce con particolare riguardo alla diagnostica differenziale fra le forme di pubertà precoce centrale o gonadotropinodipendente (PPC) e quelle gonadotropino-indipendenti o periferiche (PPGI). I criteri diagnostici generalmente usati vengono descritti e criticati e si danno indicazioni sui limiti convenzionalmente utilizzati per porre il sospetto diagnostico. Tutto cid nell’ottica di una diagnostica intesa a razionalizzare il trattamento specifico delle due forme. Gli scopi, la tipologia del trattamento, e i tempi in cui iniziare il trattamento stesso vengono descritti e viene indicato il tempo corretto da prendere in considerazione per la sospensione dei farmaci. Si indicano, inoltre, i farmaci più idonei da utilizzare e le modalità di somministrazione per la corretta terapia della pubertà precoce.

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Bibliografia

  1. Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, Hasemeier CM. Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics 99: 505, 1997.

    Article  CAS  PubMed  Google Scholar 

  2. Walvoord EC The timing of puberty: is it changing? Does it matter? J Adolesc Health 47: 433, 2010.

    Article  PubMed  Google Scholar 

  3. De Sanctis V, Corrias A, Rizzo V, Bertelloni S, Urso L, Galluzzi F, Pasquino AM, Pozzan G, Guarneri MP, Cisternino M, De Luca F, Gargantini L, Pilotta A, Sposito M, Tonini G. Etiology of central precocious puberty in males: the results of the Italian Study Group for Physiopathology of Puberty. J Pediatr Endocrinol Metab 13: 687, 2000.

    Article  PubMed  Google Scholar 

  4. Pescovitz OH, Comite F, Hench K, Barnes K, McNemar A, Foster C, Kenigsberg D, Loriaux DL, Cutler GB Jr. The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy. J Pediatr 108: 47, 1986.

    Article  CAS  PubMed  Google Scholar 

  5. Cisternino M, Arrigo T, Pasquino AM, Tinelli C, Antoniazzi F, Beduschi L, Bindi G, Borrelli P, De Sanctis V, Farello G, Galluzzi F, Gargantini L, Lo Presti D, Sposito M, Tatò L. Etiology and age incidence of precocious puberty in girls: a multicentric study. J Pediatr Endocrinol Metab 13: 695, 2000.

    Article  PubMed  Google Scholar 

  6. Stanhope R, Adams J, Brook CG. Fluctuaction of breast size in isolated premature thelarche. Acta Paediatr Scand 74: 454, 1985.

    Article  CAS  PubMed  Google Scholar 

  7. del Balzo P, Borrelli P, Cambiaso P, Danielli E, Cappa M. Adrenal steroidogenesis defects in children, with precocious pubarche. Horm Res 37: 180, 1992.

    Article  PubMed  Google Scholar 

  8. Bar A, Linder B, Sobel EH, Saenger P, DiMartino-Nardi J. Bayley-Pinneau method of height prediction in girls with central precocious puberty: correlation with adult height. J Pediatr 126: 955, 1995.

    Article  CAS  PubMed  Google Scholar 

  9. Carel JC, Leger J. Precocious puberty. N Engl J Med 358: 2366, 2008.

    Article  CAS  PubMed  Google Scholar 

  10. Mogensen SS, Aksglaede L, Mouritsen A, Sorensen K, Main KM, Gideon P, Juul A. Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty. J Clin Endocrinol Metab 96: 1393, 2011.

    Article  CAS  PubMed  Google Scholar 

  11. Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR; ESPE-LWPES GnRH Analogs Consensus Conference Group, Antoniazzi F, Berenbaum S, Bourguignon JP, Chrousos GP, Coste J, Deal S, de Vries L, Foster C, Heger S, Holland J, Jahnukainen K, Juul A, Kaplowitz P, Lahlou N, Lee MM, Lee P, Merke DP, Neely EK, Oostdijk W, Phillip M, Rosenfield RL, Shulman D, Styne D, Tauber M, Wit JM. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrcs 123: e752, 2009.

    Article  Google Scholar 

  12. Lee PA. Medroxyprogesterone therapy for sexual precocity in girls. Am J Dis Child 135: 443, 1981

    CAS  PubMed  Google Scholar 

  13. Sorgo W, Kiraly E, Homoki J, Heinze E, Teller WM, Bierich JR, Moeller H, Ranke MB, Butenandt O, Knorr D. The effects of cyproterone acetate on statural growth in children with precocious puberty. Acta Endocrinol (Copenh) 115: 44, 1987.

    CAS  Google Scholar 

  14. Arrigo T, Cisternino M, Galluzzi F, Bertelloni S, Pasquino AM, Antoniazzi F, Borrelli P, Crisafulli G, Wasniewska M, De Luca F. Analysis of the factors affecting auxological response to GnRH agonist treatment and final height outcome in girls with idiopathic central precocious puberty. Eur J Endocrinol 141: 140, 1999.

    Article  CAS  PubMed  Google Scholar 

  15. Reiter EO, Mauras N, McCormick K, Kulshreshtha B, Amrhein J, De Luca F, O’Brien S, Armstrong J, Melezinkova H. Bicalutamide plus anastrozole for the treatment of gonadotropin-independent precocious puberty in boys with testotoxicosis: a phase II, openlabel pilot study (BATT). J Pediatr Endocrinol Metab 23: 999, 2010.

    Article  CAS  PubMed  Google Scholar 

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  1. U.O.C. di Endocrinologia e Diabetologia, Dipartimento Universitario Ospedaliero, Ospedale Pediatrico Bambino Gesù, IRCCS, Piazza S. Onofrio 4, 00165, Roma, Italia

    Marco Cappa

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  1. Marco Cappa
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Correspondence to Marco Cappa.

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Cappa, M. Pubertà precoce: quando e come trattare. L’Endocrinologo 12, 297–303 (2011). https://doi.org/10.1007/BF03344857

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