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L’Endocrinologo

, Volume 12, Issue 6, pp 281–287 | Cite as

La miopatia ipotiroidea

  • Carmelo Rodolico
  • Maria Angela Pappalardo
  • Simona Portaro
  • Salvatore BenvengaEmail author
Article
  • 47 Downloads

Riassunto

Sintomi suggestivi di sofferenza muscolare (rigidità, crampi, facile stancabilità) sono riferiti da gran parte dei pazienti affetti da ipotiroidismo franco. Talvolta la sintomatologia muscolare domina il quadro clinico o addirittura può presentarsi quale unica manifestazione di esordio dell’ipotiroidismo, per cui la diagnosi differenziale con altre cause di miopatia diventa difficoltosa. La patogenesi della miopatia ipotiroidea non è del tutto nota anche se è verosimile che i suoi meccanismi siano: alterato metabolismo glicogenolitico e ossidativo, alterata espressione di proteine contrattili, danno neuro-mediato. Studi di correlazione aplotipica, di espressione genica muscolare e di caratterizzazione proteica, potrebbero aiutare la comprensione dei meccanismi fisiopatologici di questa, spesso sottostimata, presentazione miopatica dell’ipotiroidismo. Il riscontro di elevati valori sierici di creatinfosfochinasi è sicuramente suggestivo di una compromissione muscolare, senza perb specificarne l’eziologia. Oltre a tale non specificità, l’ipercreatinchinasemia non correla con la gravita della sintomatologia miopatica. Manifestazioni muscolari rare, associate all’ipotiroidismo, sono la rabdomiolisi, la sindrome compartimentale acuta, e le sindromi di Hoffman e di Kocher-Debrè-Semelaigne.

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Copyright information

© Springer International Publishing AG 2011

Authors and Affiliations

  • Carmelo Rodolico
    • 1
  • Maria Angela Pappalardo
    • 2
  • Simona Portaro
    • 1
  • Salvatore Benvenga
    • 2
    • 3
    • 4
    Email author
  1. 1.Dipartimento di Neuroscienze, Psichiatria ed Anestesiologia, A.O.U. “G. Martino”Università di MessinaMessinaItalia
  2. 2.Sezione di Endocrinologia, Dipartimento di Medicina Clinica e SperimentalePoliclinico UniversitarioMessinaItalia
  3. 3.Master in Endocrinologia dell’infanzia, dell’adolescenza e della donnaUniversità di MessinaMessinaItalia
  4. 4.Programma Interdisciplinare di Endocrinologia Molecolare Clinica e Salute Endocrina della DonnaA.O.U. Policlinico “G. Martino”MessinaItalia

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