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Il rischio di malattia conclamata nei soggetti con autoanticorpi organo-specifici

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L’Endocrinologo Aims and scope

Riassunto

Lo studio delle malattie autoimmuni e della loro storia naturale ci ha permesso di migliorare le conoscenze sul valore diagnostico e soprattutto prognostico degli autoanticorpi. Contrariamente a quanto si riteneva in passato, le malattie autoimmuni risultano malattie croniche con un lungo periodo prodromico, per lo più asintomatico, in genere caratterizzato dalla presenza nel siero dei rispettivi autoanticorpi. Nel presente articolo vengono prese in considerazione le varie malattie autoimmuni organo-specifiche, le frequenze con cui si riscontrano gli autoanticorpi nelle popolazioni a rischio o nei soggetti normali e il valore prognostico dei rispettivi autoanticorpi in funzione della malattia corrispondente. In base all’entità del rischio di sviluppo di malattia che i vari autoanticorpi comportano, i soggetti positivi asintomatici dovranno essere monitorati nel tempo per cogliere precocemente la comparsa della corrispondente disfunzione d’organo, impostare una terapia sostitutiva specifica precoce ed eventualmente realizzare dei trial di prevenzione.

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  1. Unità Operativa Complessa di Endocrinologia, Cattedra di Immunologia Clinica e Allergologia, Dipartimento di Scienze Mediche e Chirurgiche, Università degli Studi di Padova, Via Ospedale Civile 105, 35128, Padova, Italia

    Corrado Betterle & Fabio Presotto

  2. Unità Operativa Complessa di Medicina Interna, Ospedale di Este, Padova, Italia

    Fabio Presotto

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  1. Corrado Betterle
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Betterle, C., Presotto, F. Il rischio di malattia conclamata nei soggetti con autoanticorpi organo-specifici. L’Endocrinologo 12, 134–144 (2011). https://doi.org/10.1007/BF03344808

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