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Ipotiroidismo subclinico: indicazioni al trattamento

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Riassunto

L’ipotiroidismo subclinico è una condizione caratterizzata da un incremento del TSH con ormoni tiroidei normali. Benché la secrezione di ormoni tiroidei sia apparentemente normale, i soggetti con tale pattern ormonale possono essere sintomatici e presentare alterazioni a carico dei loro organi e tessuti bersaglio, che, se non corrette, possono indurre spesso complicanze in grado di modificare la qualità e le aspettative di vita. L’ipotiroidismo subclinico è relativamente frequente nella popolazione generale e, specie negli anziani determina un elevato rischio cardiovascolare per la possibilità di alterazione di vari parametri cardiovascolari e per l’aumentato rischio di aterosclerosi. Tra i fattori di rischio per aterosclerosi un ruolo importante sembra essere svolto dall’ipertensione, dalla disfunzione endoteliale, dalla dislipidemia e dalle alterazioni dei parametri di coagulazione. La terapia con T4 riesce a prevenire o a correggere l’aumentato rischio cardiovascolare associato all’ipotiroidismo subclinico, nonché a migliorare la qualità di vita, i disturbi psichici, cognitivi e muscolari che pure possono essere presenti. Il trattamento dell’ipotiroidismo subclinico è imperativo in gravidanza per le gravi alterazioni che può indurre nel nascituro.

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Correspondence to Bernadette Biondi.

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Biondi, B., Pagano, L., Pulcrano, M. et al. Ipotiroidismo subclinico: indicazioni al trattamento. L’Endocrinologo 6, 36–41 (2005). https://doi.org/10.1007/BF03344510

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  • DOI: https://doi.org/10.1007/BF03344510

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