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Terapia della calvizie e dell’irsutismo con inibitori della 5α-riduttasi

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L’Endocrinologo Aims and scope

Riassunto

L’enzima steroidi 5α-riduttasi, che comprende due isoenzimi denominati tipo 1 e tipo 2, ha un ruolo fondamentale nel metabolismo degli androgeni poiché catalizza la conversione del testosterone in diidrotestosterone (DHT). Il DHT è l’androgeno più potente dell’organismo e svolge un ruolo fisiologico fondamentale nella differenziazione sessuale e nello sviluppo dei genitali esterni del feto. Il DHT è anche coinvolto nella patogenesi e nello sviluppo di patologie importanti e molto comuni quali l’ipertrofia prostatica benigna, il carcinoma della prostata, la calvizie maschile e l’irsutismo femminile. La sintesi di inibitori della 5α-riduttasi riveste quindi un notevole interesse clinico per lo sviluppo di farmaci per la cura di queste patologie.

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Authors and Affiliations

  1. Dipartimento di Fisiopatologia clinica, Unità di Endocrinologia, Università degli Studi di Firenze, Viale Pieraccini 6, 50139, Firenze, Italia

    Antonio Cilotti, Giovanna Danza &  Mario Serio

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  1. Antonio Cilotti
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  2. Giovanna Danza
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  3. Mario Serio
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Correspondence to Mario Serio.

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Cilotti, A., Danza, G. & Serio, M. Terapia della calvizie e dell’irsutismo con inibitori della 5α-riduttasi. L’Endocrinologo 1, 3–12 (2000). https://doi.org/10.1007/BF03344364

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