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Giftschlangenbisse — eine globale Herausforderung

Venomous snake bites — a global challenge

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Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie Aims and scope Submit manuscript

Zusammenfassung

Giftschlangen kommen in vielen Regionen der Welt vor und haben zahlreiche Lebensräume erobert. Sie sind weltweit für etwa 2,5 Millionen Bisse und 100 000 Todesfälle verantwortlich. Die epidemiologische Erfassung der Unfälle mit Giftschlangen erfolgt in den meisten Ländern nur lückenhaft.

Im Falle einer Vergiftung ist die Vielfalt an Symptomen komplex und keineswegs vorhersehbar. Die zur Verfügung stehenden Therapiemöglichkeiten sind begrenzt.

Der vorliegende Übersichtsartikel befasst sich mit Giftschlangenbissen und der Wirkung von Schlangengift beim Menschen.

Summary

Venomous snakes exist in many regions of the world and have conquered various habitats. About 2.5 Million humans suffer from snake bite accidents worldwide and approximately 100.000 of those bitten die. In most countries, the epidemiological registration of snake bite accidents is generally incomplete.

In case of envenomation, symptoms are complex, may vary and are by no means predictable. Therapeutical options are limited.

The current review explores the importance of venomous snake bites and action of snake venom in humans.

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Literatur

  • Acosta O, Leiva LC, Peichoto ME, Marunak S, Teibler P, Rey L (2003) Hemorrhagic activity of the Duvernoy’s gland secretion of the xenodontine colubrid Philodryas patagoniensis from the north-east region of Argentina. Toxicon 41: 1007–1012

    PubMed  CAS  Google Scholar 

  • Alape-Giron A, Sanz L, Escolano J, Flores-Diaz M, Madrigal M, Sasa M, Calvete JJ (2008) Snake Venomics of the Lancehead Pitviper Bothrops asper: Geographic, Individual, and Ontogenetic Variations. J Proteome Res

  • Apel C, Ricny J, Wagner G, Wessler I (1995) alpha-Bungarotoxin, kappa-bungarotoxin, alphacobratoxin and erabutoxin-b do not affect [3H]acetylcholine release from the rat isolated left hemidiaphragm. Naunyn Schmiedebergs Arch Pharmacol 352: 646–652

    PubMed  CAS  Google Scholar 

  • Aravanis C, Ioannidis PJ, Ktenas J (1982) Acute myocardial infarction and cerebrovascular accident in a young girl after a viper bite. Br Heart J 47: 500–503

    PubMed Central  PubMed  CAS  Google Scholar 

  • Bellefleur JP, Le Dantec P (2005) Hospital care of snakebites in Africa. Bull Soc Pathol Exot 98: 273–276

    PubMed  CAS  Google Scholar 

  • Bochner R, Struchiner CJ (2003) Snake bite epidemiology in the last 100 years in Brazil: a review. Cad Saude Publica 19: 7–16

    PubMed  Google Scholar 

  • Britt A, Burkhart K (1997) Naja naja cobra bite. Am J Emerg Med 15: 529–531

    PubMed  CAS  Google Scholar 

  • Brook GA, Torres LF, Gopalakrishnakone P, Duchen LW (1987) Effects of phospholipase of Enhydrina schistosa venom on nerve, motor end-plate and muscle of the mouse. Q J Exp Physiol 72: 571–591

    PubMed  CAS  Google Scholar 

  • Bucaretchi F, Hyslop S, Mello SM, Vieira RJ (2007) Bothrops snakebite on the head: case report and review of the literature. Ann Trop Med Parasitol 101: 733–743

    PubMed  CAS  Google Scholar 

  • Bucaretchi F, Hyslop S, Vieira RJ, Toledo AS, Madureira PR, de Capitani EM (2006) Bites by coral snakes (Micrurus spp.) in Campinas, State of Sao Paulo, Southeastern Brazil. Rev Inst Med Trop Sao Paulo 48: 141–145

    PubMed  Google Scholar 

  • Calvete JJ, Juarez P, Sanz L (2007) Snake venomics. Strategy and applications. J Mass Spectrom 42: 1405–1414

    PubMed  CAS  Google Scholar 

  • Cawrse NH, Inglefield CJ, Hayes C, Palmer JH (2002) A snake in the clinical grass: late compartment syndrome in a child bitten by an adder. Br J Plast Surg 55: 434–435

    PubMed  CAS  Google Scholar 

  • Cheng AC, Currie BJ (2004) Venomous snakebites worldwide with a focus on the Australia-Pacific region: current management and controversies. J Intensive Care Med 19: 259–269

    PubMed  Google Scholar 

  • Cher CD, Armugam A, Zhu YZ, Jeyaseelan K (2005) Molecular basis of cardiotoxicity upon cobra envenomation. Cell Mol Life Sci 62: 105–118

    PubMed  CAS  Google Scholar 

  • Ching AT, Rocha MM, Paes Leme AF, Pimenta DC, de Fatima DFM, Serrano SM, Ho PL, Junqueira-de-Azevedo IL (2006) Some aspects of the venom proteome of the Colubridae snake Philodryas olfersii revealed from a Duvernoy’s (venom) gland transcriptome. FEBS Lett 580: 4417–4422

    PubMed  CAS  Google Scholar 

  • Chippaux JP (1998) Snake-bites: appraisal of the global situation. Bull World Health Organ 76: 515–524

    PubMed Central  PubMed  CAS  Google Scholar 

  • Chippaux JP, Goyffon M (1997) Snakes and scorpions: what are the risks for the traveler?. Med Trop (Mars) 57: 519–521

    CAS  Google Scholar 

  • Chippaux JP, Kambewasso A (2002) Snake bites and antivenom availability in the urban community of Niamey, Niger. Bull Soc Pathol Exot 95: 181–183

    PubMed  CAS  Google Scholar 

  • Chotenimitkhun R, Rojnuckarin P (2008) Systemic antivenom and skin necrosis after green pit viper bites. Clin Toxicol (Phila) 46: 122–125

    CAS  Google Scholar 

  • Cupo P, Azevedo-Marques MM, Hering SE (1990) Acute myocardial infarction-like enzyme profile in human victims of Crotalus durissus terrificus envenoming. Trans R Soc Trop Med Hyg 84: 447–451

    PubMed  CAS  Google Scholar 

  • Currie BJ (2006) Treatment of snakebite in Australia: the current evidence base and questions requiring collaborative multicentre prospective studies. Toxicon 48: 941–956

    PubMed  CAS  Google Scholar 

  • Daltry JC, Wuster W, Thorpe RS (1996) Diet and snake venom evolution. Nature 379: 537–540

    PubMed  CAS  Google Scholar 

  • Dart RC, McNally J (2001) Efficacy, safety, and use of snake antivenoms in the United States. Ann Emerg Med 37: 181–188

    PubMed  CAS  Google Scholar 

  • Dash S, Dash RJ (1980) Spectrum of haemolytic anaemias in Punjab, North India. Trop Geogr Med 32: 312–316

    PubMed  CAS  Google Scholar 

  • de Rezende NA, Torres FM, Dias MB, Campolina D, Chavez-Olortegui C, Amaral CF (1998) South American rattlesnake bite (Crotalus durissus SP) without envenoming: insights on diagnosis and treatment. Toxicon 36: 2029–2032

    PubMed  Google Scholar 

  • Deufel A, Cundall D (2003) Feeding in Atractaspis (Serpentes: Atractaspididae): a study in conflicting functional constraints. Zoology (Jena) 106: 43–61

    Google Scholar 

  • Dumavibhat B (1997) A study of epidemiology, risk factors and preventive measures against snake bites. J Med Assoc Thai 80: 547–556

    PubMed  CAS  Google Scholar 

  • Fadel V, Bettendorff P, Herrmann T, de Azevedo WF, Jr., Oliveira EB, Yamane T, Wuthrich K (2005) Automated NMR structure determination and disulfide bond identification of the myotoxin crotamine from Crotalus durissus terrificus. Toxicon 46: 759–767

    PubMed  CAS  Google Scholar 

  • Faure G, Gowda VT, Maroun RC (2007) Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics. BMC Struct Biol 7: 82

    PubMed Central  PubMed  Google Scholar 

  • Fazelat J, Teperman SH, Touger M (2008) Recurrent hemorrhage after western diamondback rattlesnake envenomation treated with crotalidae polyvalent immune fab (ovine). Clin Toxicol (Phila): 1–4

  • Forks TP (1994) Evaluation and treatment of poisonous snakebites. Am Fam Physician 50: 123–130, 135

    PubMed  CAS  Google Scholar 

  • Fox JW, Serrano SM (2008) Exploring snake venom proteomes: multifaceted analyses for complex toxin mixtures. Proteomics 8: 909–920

    PubMed  CAS  Google Scholar 

  • Frangides CY, Koulouras V, Kouni SN, Tzortzatos GV, Nikolaou A, Pneumaticos J, Pierrakeas C, Niarchos C, Kounis NG, Koutsojannis CM (2006) Snake venom poisoning in Greece. Experiences with 147 cases. Eur J Intern Med 17: 24–27

    PubMed  Google Scholar 

  • German BT, Hack JB, Brewer K, Meggs WJ (2005) Pressure-immobilization bandages delay toxicity in a porcine model of eastern coral snake (Micrurus fulvius fulvius) envenomation. Ann Emerg Med 45: 603–608

    PubMed  Google Scholar 

  • Gibly RL, Walter FG, Nowlin SW, Berg RA (1998) Intravascular hemolysis associated with North American crotalid envenomation. J Toxicol Clin Toxicol 36: 337–343

    PubMed  CAS  Google Scholar 

  • Girish KS, Jagadeesha DK, Rajeev KB, Kemparaju K (2002) Snake venom hyaluronidase: an evidence for isoforms and extracellular matrix degradation. Mol Cell Biochem 240: 105–110

    PubMed  CAS  Google Scholar 

  • Gold BS, Dart RC, Barish RA (2002) Bites of venomous snakes. N Engl J Med 347: 347–356

    PubMed  Google Scholar 

  • Gold BS, Pyle P (1998) Successful treatment of neurotoxic king cobra envenomation in Myrtle Beach, South Carolina. Ann Emerg Med 32: 736–738

    PubMed  CAS  Google Scholar 

  • Gundappa RK, Sud K, Kohli HS, Jha V, Gupta KL, Joshi K, Sakhuja V, (2002) Snakebite induced acute interstitial nephritis: report of a rare entity. Ren Fail 24: 369–372

    PubMed  Google Scholar 

  • Gutierrez JM, Arroyo O, Chaves F, Lomonte B, Cerdas L (1986) Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice. Br J Exp Pathol 67: 1–12

    PubMed Central  PubMed  CAS  Google Scholar 

  • Haddad V Jr., Neto DG, de Paula Neto JB, de Luna Marques FP, Barbaro KC (2004) Freshwater stingrays: study of epidemiologic, clinic and therapeutic aspects based on 84 envenomings in humans and some enzymatic activities of the venom. Toxicon 43: 287–294

    PubMed  CAS  Google Scholar 

  • Harris JB, Goonetilleke A (2004) Animal poisons and the nervous system: what the neurologist needs to know. J Neurol Neurosurg Psychiatry 75 Suppl 3: iii 40–46

    Google Scholar 

  • Hasle G (2002) Dangerous animals. Tidsskr Nor Laegeforen 122: 1695–1701

    PubMed  Google Scholar 

  • Hawgood BJ (1999) Doctor Albert Calmette 1863–1933: founder of antivenomous serotherapy and of antituberculous BCG vaccination. Toxicon 37: 1241–1258

    PubMed  CAS  Google Scholar 

  • Hawgood BJ (2007) Albert Calmette (1863–1933) and Camille Guerin (1872–1961): the C and G of BCG vaccine. J Med Biogr 15: 139–146

    PubMed  Google Scholar 

  • Hayes WK, Lavin-Murcio P, Kardong KV (1993) Delivery of Duvernoy’s secretion into prey by the brown tree snake, Boiga irregularis (Serpentes:Colubridae). Toxicon 31: 881–887

    PubMed  CAS  Google Scholar 

  • He YY, Lee WH, Zhang Y (2004) Cloning and purification of alpha-neurotoxins from king cobra (Ophiophagus hannah). Toxicon 44: 295–303

    PubMed  CAS  Google Scholar 

  • Hill RE, Mackessy SP (2000) Characterization of venom (Duvernoy’s secretion) from twelve species of colubrid snakes and partial sequence of four venom proteins. Toxicon 38: 1663–1687

    PubMed  CAS  Google Scholar 

  • Howes JM, Kamiguti AS, Theakston RD, Wilkinson MC, Laing GD (2005) Effects of three novel metalloproteinases from the venom of the West African saw-scaled viper, Echis ocellatus on blood coagulation and platelets. Biochim Biophys Acta 1724: 194–202

    PubMed  CAS  Google Scholar 

  • Isbister GK, Brown SG, MacDonald E, White J, Currie BJ (2008) Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxis. Med J Aust 188: 473–476

    PubMed  Google Scholar 

  • Ismail M, Memish ZA (2003) Venomous snakes of Saudi Arabia and the Middle East: a keynote for travellers. Int J Antimicrob Agents 21: 164–169

    PubMed  CAS  Google Scholar 

  • Jackson K (2002) How tubular venom-conducting fangs are formed. J Morphol 252: 291–297

    PubMed  Google Scholar 

  • Jackson K (2007) The evolution of venom-conducting fangs: insights from developmental biology. Toxicon 49: 975–981

    PubMed  CAS  Google Scholar 

  • Jayne BC, Voris HK, Ng PK (2002) Snake circumvents constraints on prey size. Nature 418: 143

    PubMed  CAS  Google Scholar 

  • John J, Gane BD, Plakkal N, Aghoram R, Sampath S (2008) Snake bite mimicking brain death. Cases J 1: 16

    PubMed Central  PubMed  Google Scholar 

  • Jorge MT, Ribeiro LA (1992) The epidemiology and clinical picture of an accidental bite by the South American rattlesnake (Crotalus durissus). Rev Inst Med Trop Sao Paulo 34: 347–354

    PubMed  CAS  Google Scholar 

  • Jorge MT, Sano-Martins IS, Tomy SC, Castro SC, Ferrari RA, Ribeiro LA, Warrell DA (1997) Snakebite by the bushmaster (Lachesis muta) in Brazil: case report and review of the literature. Toxicon 35: 545–554

    PubMed  CAS  Google Scholar 

  • Junghanss T, Bodio M (2006) Medically important venomous animals: biology, prevention, first aid, and clinical management. Clin Infect Dis 43: 1309–1317

    PubMed  Google Scholar 

  • Kanjanabuch T, Sitprija V (2008) Snakebite nephrotoxicity in Asia. Semin Nephrol 28: 363–372

    PubMed  Google Scholar 

  • Karlson-Stiber C, Salmonson H, Persson H (2006) A nationwide study of Vipera berus bites during one year-epidemiology and morbidity of 231 cases. Clin Toxicol (Phila) 44: 25–30

    Google Scholar 

  • Karthik S, Phadke KD (2004) Snakebite-induced acute renal failure. A case report and review of the literature. Pediatr Nephrol 19: 1053–1054

    PubMed  Google Scholar 

  • Kerrigan KR (1991) Venomous snakebite in eastern Ecuador. Am J Trop Med Hyg 44: 93–99

    PubMed  CAS  Google Scholar 

  • Kim KK (1996) Exogenous causes of myoglobinuria — review of 26 cases. J Korean Med Sci 11: 342–346

    PubMed Central  PubMed  CAS  Google Scholar 

  • Kularatne SA (2003) Epidemiology and clinical picture of the Russell’s viper (Daboia russelii russelii) bite in Anuradhapura, Sri Lanka: a prospective study of 336 patients. Southeast Asian J Trop Med Public Health 34: 855–862

    PubMed  CAS  Google Scholar 

  • Kurecki BA, 3rd, Brownlee HJ, Jr. (1987) Venomous snakebites in the United States. J Fam Pract 25: 386–392

    PubMed  Google Scholar 

  • Kuruppu S, Robinson S, Hodgson WC, Fry BG (2007) The in vitro neurotoxic and myotoxic effects of the venom from the Suta genus (curl snakes) of elapid snakes. Basic Clin Pharmacol Toxicol 101: 407–410

    PubMed  CAS  Google Scholar 

  • Lalloo DG, Trevett AJ, Saweri A, Naraqi S, Theakston RD, Warrell DA (1995) The epidemiology of snake bite in Central Province and National Capital District, Papua New Guinea. Trans R Soc Trop Med Hyg 89: 178–182

    PubMed  CAS  Google Scholar 

  • Larreche S, Mion G, Clapson P, Debien B, Wybrecht D, Goyffon M (2008) Neurotoxins from snake venom. Ann Fr Anesth Reanim 27: 310–316

    PubMed  CAS  Google Scholar 

  • Lee MS, Scanlon JD (2002) Snake phylogeny based on osteology, soft anatomy and ecology. Biol Rev Camb Philos Soc 77: 333–401

    PubMed  Google Scholar 

  • Leikin JB, Aks SE, Andrews S, Auerbach PS, Cooper MA, Jacobsen TD, Krenzelok EP, Shicker L, Weiner SL (1997) Environmental injuries. Dis Mon 43: 809–916

    PubMed  CAS  Google Scholar 

  • Lonati D, Butera R, Cima M, Cozzio S, Locatelli C, Manzo L (2004) Exotic snakes in Europe. A case of Mexican Moccasin (Agkistrodon bilineatus) snakebite. Presse Med 33: 1582–1584

    PubMed  Google Scholar 

  • Marsh N, Gattullo D, Pagliaro P, Losano G (1997) The Gaboon viper, Bitis gabonica: hemorrhagic, metabolic, cardiovascular and clinical effects of the venom. Life Sci 61: 763–769

    PubMed  CAS  Google Scholar 

  • Mebs D (2000) Gifttiere. Ein Handbuch für Biologen, Toxikologen, Ärzte und Apotheker. 2 ed. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH 350

    Google Scholar 

  • Miao YN, Chen MC, Huang Z (2003) Clinical observation on treatment of snake bite induced disseminated intravascular coagulation by qinwen baidu decoction. Zhongguo Zhong Xi Yi Jie He Za Zhi 23: 590–592

    PubMed  Google Scholar 

  • Morgan DL, Blair HW, Ramsey RP (2006) Suicide attempt by the intravenous injection of rattlesnake venom. Southern Medical Journal 99: 282–284

    PubMed  Google Scholar 

  • Mosquera A, Idrovo LA, Tafur A, Del Brutto OH (2003) Stroke following Bothrops spp. snakebite. Neurology 60: 1577–1580

    PubMed  Google Scholar 

  • Murdock RT, White GL Jr., Pedersen DM, De-Faller JM, Snyder CC (1990) Prevention and emergency field management of venomous snakebites during military exercises. Mil Med 155: 587–590

    PubMed  CAS  Google Scholar 

  • Nishioka Sde A, Silveira PV, Bauab FA (1995) Bite marks are useful for the differential diagnosis of snakebite in Brazil. Wilderness Environ Med 6: 183–188

    Google Scholar 

  • O’Leary MA, Schneider JJ, Krishnan BP, Lavis C, McKendry A, Ong LK, Isbister GK (2007) Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures? Toxicon 50: 206–213

    PubMed  Google Scholar 

  • O’Neil ME, Mack KA, Gilchrist J, Wozniak EJ (2007) Snakebite injuries treated in United States emergency departments, 2001–2004. Wilderness Environ Med 18: 281–287

    PubMed  Google Scholar 

  • Oliveira DA, Harasawa C, Seibert CS, Casais e Silva LL, Pimenta DC, Lebrun I, Sandoval MR (2008) Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: behavioral, electroencephalographic, and neuropathological aspects. Brain Res Bull 75: 629–639

    PubMed  CAS  Google Scholar 

  • Otero R, Gutierrez J, Beatriz Mesa M, Duque E, Rodriguez O, Luis Arango J, Gomez F, Toro A, Cano F, Maria Rodriguez L, Caro E, Martinez J, Cornejo W, Mariano Gomez L, Luis Uribe F, Cardenas S, Nunez V, Diaz A (2002) Complications of Bothrops, Porthidium, and Bothriechis snakebites in Colombia. A clinical and epidemiological study of 39 cases attended in a university hospital. Toxicon 40: 1107–1114

    PubMed  CAS  Google Scholar 

  • Pahari S, Mackessy SP, Kini RM (2007) The venom gland transcriptome of the Desert Massasauga rattlesnake (Sistrurus catenatus edwardsii): towards an understanding of venom composition among advanced snakes (Super-family Colubroidea). BMC Mol Biol 8: 115

    PubMed Central  PubMed  Google Scholar 

  • Pearn J, Morrison J, Charles N, Muir V (1981) First-aid for snake-bite: efficacy of a constrictive bandage with limb immobilization in the management of human envenomation. Med J Aust 2: 293–295

    PubMed  CAS  Google Scholar 

  • Persson H (2001) Envenoming by European vipers antivenom treatment — influence on morbidity. Przegl Lek 58: 223–225

    PubMed  CAS  Google Scholar 

  • Peterson ME (2006) Snake bite: coral snakes. Clin Tech Small Anim Pract 21: 183–186

    PubMed  Google Scholar 

  • Peterson ME (2006) Snake bite: pit vipers. Clin Tech Small Anim Pract 21: 174–182

    PubMed  Google Scholar 

  • Petite J (2005) Viper bites: treat or ignore? Review of a series of 99 patients bitten by Vipera aspis in an alpine Swiss area. Swiss Med Wkly 135: 618–625

    PubMed  Google Scholar 

  • Petrovan RJ, Rapaport SI, Le DT (1999) A novel clotting assay for quantitation of plasma prothrombin (factor II) using Echis multisquamatus venom. Am J Clin Pathol 112: 705–711

    PubMed  CAS  Google Scholar 

  • Phillips RE, Theakston RD, Warrell DA, Galigedara Y, Abeysekera DT, Dissanayaka P, Hutton RA, Aloysius DJ (1988) Paralysis, rhabdomyolysis and haemolysis caused by bites of Russell’s viper (Vipera russelli pulchella) in Sri Lanka: failure of Indian (Haffkine) antivenom. Q J Med 68: 691–715

    PubMed  CAS  Google Scholar 

  • Pinho FM, Zanetta DM, Burdmann EA (2005) Acute renal failure after Crotalus durissus snakebite: a prospective survey on 100 patients. Kidney Int 67: 659–667

    PubMed  Google Scholar 

  • Plowman DM, Reynolds TL, Joyce SM (1995) Poisonous snakebite in Utah. West J Med 163: 547–551

    PubMed Central  PubMed  CAS  Google Scholar 

  • Ponraj D, Gopalakrishnakone P (1996) Establishment of an animal model for myoglobinuria by use of a myotoxin from Pseudechis australis (king brown snake) venom in mice. Lab Anim Sci 46: 393–398

    PubMed  CAS  Google Scholar 

  • Prenzel F, Schulz M, Siekmeyer W, Rahn W, Kiess W (2008) Adder bites — clinical picture, diagnosis and management. Dtsch Med Wochenschr 133: 1075–1080

    PubMed  CAS  Google Scholar 

  • Re G, Trisolino G, Miglio F (1999) Eye muscle paralysis after Vipera aspis envenomation. J Accid Emerg Med 16: 458

    PubMed Central  PubMed  CAS  Google Scholar 

  • Rigoni M, Schiavo G, Weston AE, Caccin P, Allegrini F, Pennuto M, Valtorta F, Montecucco C, Rossetto O (2004) Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles. J Cell Sci 117: 3561–3570

    PubMed  CAS  Google Scholar 

  • Russell FE, Walter FG, Bey TA, Fernandez MC (1997) Snakes and snakebite in Central America. Toxicon 35: 1469–1522

    PubMed  CAS  Google Scholar 

  • Sakwiwatkul K, Chaiyabutr N, Sitprija V (2002) Renal function following sea snake venom (Lapemis hardwicki) administration in dogs treated with sodium bicarbonate solution. J Nat Toxins 11: 111–121

    PubMed  CAS  Google Scholar 

  • Sanz L, Escolano J, Ferretti M, Biscoglio MJ, Rivera E, Crescenti EJ, Angulo Y, Lomonte B, Gutierrez JM, Calvete JJ (2008) Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis. J Proteomics 71: 46–60

    PubMed  CAS  Google Scholar 

  • Sasa M, Vazquez S (2003) Snakebite envenomation in Costa Rica: a revision of incidence in the decade 1990–2000. Toxicon 41: 19–22

    PubMed  CAS  Google Scholar 

  • Savitzky AH, Moon BR (2008) Tail morphology in the Western Diamond-backed rattlesnake, Crotalus atrox. J Morphol 269: 935–944

    PubMed  Google Scholar 

  • Schaper A, Desel H, Ebbecke M, de Haro L, Deters M, Hentschel H, Hermanns-Clausen M, Langer C (2008) Bites and stings by exotic pets in Europe: An 11 year analysis of 404 cases from Northeastern Germany and Southeastern France. Clin Toxicol (Phila): 1–5

  • Schneemann M, Cathomas R, Laidlaw ST, El Nahas AM, Theakston RD, Warrell DA (2004) Life-threatening envenoming by the Saharan horned viper (Cerastes cerastes) causing microangiopathic haemolysis, coagulopathy and acute renal failure: clinical cases and review. Qjm 97: 717–727

    PubMed  CAS  Google Scholar 

  • Seifert SA, Oakes JA, Boyer LV (2007) Toxic Exposure Surveillance System (TESS)-based characterization of U.S. non-native venomous snake exposures, 1995–2004. Clin Toxicol (Phila) 45: 571–578

    Google Scholar 

  • Seignot P, Ducourau JP, Ducrot P, Angel G, Roussel L, Aubert M (1992) Fatal poisoning caused by African viper’s bite (Echis carinatus). Ann Fr Anesth Reanim 11: 105–110

    PubMed  CAS  Google Scholar 

  • Serrano SM, Shannon JD, Wang D, Camargo AC, Fox JW (2005) A multifaceted analysis of viperid snake venoms by two-dimensional gel electrophoresis: an approach to understanding venom proteomics. Proteomics 5: 501–510

    PubMed  CAS  Google Scholar 

  • Shiau DT, Sanders JW, Putnam SD, Buff A, Beasley W, Tribble DR, Riddle MS (2007) Selfreported incidence of snake, spider, and scorpion encounters among deployed U.S. military in Iraq and Afghanistan. Mil Med 172: 1099–1102

    PubMed  Google Scholar 

  • Simes DC (2002) Early and late removal of the pressure bandage in brown snake envenomation: a report of two cases. Crit Care Resusc 4: 116–118

    PubMed  CAS  Google Scholar 

  • Sitprija V (2006) Snakebite nephropathy. Nephrology (Carlton) 11: 442–448

    CAS  Google Scholar 

  • Suchithra N, Pappachan JM, Sujathan P (2008) Snakebite envenoming in Kerala, South India: clinical profile and factors involved in adverse outcomes. Emerg Med J 25: 200–204

    PubMed  CAS  Google Scholar 

  • Tans G, Rosing J (2001) Snake venom activators of factor X: an overview. Haemostasis 31: 225–233

    PubMed  CAS  Google Scholar 

  • Thachil RT, Tony JC, Jude E, Ross C, Vincent ND, Sridhar CB (1992) Antisnakevenom: an over-used medication. Trop Doct 22: 113–115

    PubMed  CAS  Google Scholar 

  • Tibballs J, Henning RD, Sutherland SK, Kerr AR (1991) Fatal cerebral haemorrhage after tiger snake (Notechis scutatus) envenomation. Med J Aust 154: 275–276

    PubMed  CAS  Google Scholar 

  • Top LJ, Tulleken JE, Ligtenberg JJ, Meertens JH, van der Werf TS, Zijlstra JG (2006) Serious envenomation after a snakebite by a Western bush viper (Atheris chlorechis) in the Netherlands: a case report. Neth J Med 64: 153–156

    PubMed  CAS  Google Scholar 

  • Toyama OD, Boschero CA, Martins AM, Fonteles CM, Monteiro SH, Toyama HM (2005) Structure-function relationship of new crotamine isoform from the Crotalus durissus cascavella. Protein J 24: 9–19

    PubMed  CAS  Google Scholar 

  • Veto T, Price R, Silsby JF, Carter JA (2007) Treatment of the first known case of king cobra envenomation in the United Kingdom, complicated by severe anaphylaxis. Anaesthesia 62: 75–78

    PubMed  CAS  Google Scholar 

  • Warrell DA (2001) „To search and Studdy out the secrett of Tropical Diseases by way of Experiment“. Lancet 358: 1983–1988

    PubMed  CAS  Google Scholar 

  • Warrell DA (2005) Treatment of bites by adders and exotic venomous snakes. Bmj 331: 1244–1247

    PubMed Central  PubMed  Google Scholar 

  • Warrell DA, Arnett C (1976) The importance of bites by the saw-scaled or carpet viper (Echis carinatus): epidemiological studies in Nigeria and a review of the world literature. Acta Trop 33: 307–341

    PubMed  CAS  Google Scholar 

  • White J (2000) Bites and stings from venomous animals: a global overview. Ther Drug Monit 22: 65–68

    PubMed  CAS  Google Scholar 

  • Williams D, Wuster W, Fry BG (2006) The good, the bad and the ugly: Australian snake taxonomists and a history of the taxonomy of Australia’s venomous snakes. Toxicon 48: 919–930

    PubMed  CAS  Google Scholar 

  • Wozniak EJ, Wisser J, Schwartz M (2006) Venomous adversaries: a reference to snake identification, field safety, and bite-victim first aid for disaster-response personnel deploying into the hurricane-prone regions of North America. Wilderness Environ Med 17: 246–266

    PubMed  Google Scholar 

  • Yamamoto C, Tsuru D, Oda-Ueda N, Ohno M, Hattori S, Kim ST (2001) Trimeresurus flavoviridis (habu snake) venom induces human erythrocyte lysis through enzymatic lipolysis, complement activation and decreased membrane expression of CD55 and CD59. Pharmacol Toxicol 89: 188–194

    PubMed  CAS  Google Scholar 

  • Young BA, Blair M, Zahn K, Marvin J (2001) Mechanics of venom expulsion in Crotalus, with special reference to the role of the fang sheath. Anat Rec 264: 415–426

    PubMed  CAS  Google Scholar 

  • Young BA, Kardong KV (2007) Mechanisms controlling venom expulsion in the western diamondback rattlesnake, Crotalus atrox. J Exp Zool Part A Ecol Genet Physiol 307: 18–27

    Google Scholar 

  • Young BA, Zahn K (2001) Venom flow in rattlesnakes: mechanics and metering. J Exp Biol 204: 4345–4351

    PubMed  CAS  Google Scholar 

  • Zahradnicek O, Horacek I, Tucker AS (2008) Viperous fangs: Development and evolution of the venom canal. Mech Dev

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Geier, M.V., Quarcoo, D., Spallek, M.F. et al. Giftschlangenbisse — eine globale Herausforderung. Zbl Arbeitsmed 59, 8–21 (2009). https://doi.org/10.1007/BF03344195

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