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Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat

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Abstract

Obestatin is a recently discovered 23 amino acids peptide derived from the ghrelin gene. As opposed to ghrelin, obestatin was shown to inhibit food intake in mice. The aims of this research were to study the effects of acute obestatin treatment on feeding behavior in the rat and its effects on GH and corticosterone secretion. Our results demonstrate that in young-adult male rats, obestatin effectively blunts the hunger caused by short-term starvation. Obestatin did not modify GH secretion in 10-day-old rats and did not antagonize the GH-releasing effects of hexarelin. Moreover, obestatin administration had no effects on spontaneous corticosterone secretion. In conclusion, these data demonstrate that in young-adult male rats the newly discovered obestatin can inhibit feeding but does not modify GH and corticosterone release in infant rats.

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References

  1. Zhang JV, Ren PG, Avsian-Kretchmer O, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake. Science 2005, 5750: 996–9.

    Article  Google Scholar 

  2. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide fron stomach. Nature 1999, 402: 656–60.

    Article  CAS  PubMed  Google Scholar 

  3. Szentirmai E, Krueger JM. Obestatin alters sleep in rats. Neurosci Lett 2006, 1–2: 222–6.

    Article  Google Scholar 

  4. Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001, 12: 5992.

    Article  Google Scholar 

  5. Wren AM, Small CJ, Abbott CR, et al. Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001, 11: 2540–7.

    Article  Google Scholar 

  6. Steiger A. Sleep and endocrinology. J Intern Med. 2003, 1: 13–22.

    Article  Google Scholar 

  7. van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004, 3: 426–57.

    Article  Google Scholar 

  8. Giordano R, Picu A, Broglio F, et al. Ghrelin, hypothalamus-pituitary-adrenal (HPA) axis and Cushing’s syndrome. Pituitary 2004, 4: 243–8.

    Article  Google Scholar 

  9. Torsello A, Luoni M, Schweiger F, et al. Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release. Eur J Pharmacol 1998, 2–3: 123–9.

    Article  Google Scholar 

  10. Deghenghi R, Cananzi MM, Torsello A, Battisti C, Muller EE, Locatelli V. GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats. Life Sci 1994, 18: 1321–8.

    Article  Google Scholar 

  11. Pan W, Tu H, Kastin AJ. Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides 2006, 4: 911–6.

    Article  Google Scholar 

  12. Petrovich GD, Gallagher M. Amygdala subsystems and control of feeding behavior by learned cues. Ann NY Acad Sci 2003, 985: 251–262.

    Article  PubMed  Google Scholar 

  13. Solomon A, De Fanti BA, Martinez JA. The nucleus tractus solitari (NTS) participates in peripheral ghrelin glucostatic hunger signalling mediated by insulin. Neuropeptides2006, 3: 169–7

  14. Gilg S, Lutz TA. The orexigenic effect of peripheral ghrelin differs between rats of different age and with different baseline food intake, and it may in part be mediated by the area postrema. Physiol Behav 2006, 2: 353–9.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Experimental Medicine, University of Milano-Bicocca, Via Cadore 48, 20052, Monza (MI), Italy

    E. Bresciani PhD, D. Rapetti, F. Donà, I. Bulgarelli, L. Tamiazzo, V. Locatelli & A. Torsello

  2. Interdepartmental Center for Bioinformatics and Proteomics, University of Milano-Bicocca, Monza (MI), Italy

    V. Locatelli & A. Torsello

Authors
  1. E. Bresciani PhD
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  2. D. Rapetti
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  3. F. Donà
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  4. I. Bulgarelli
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  5. L. Tamiazzo
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  6. V. Locatelli
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  7. A. Torsello
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Correspondence to E. Bresciani PhD.

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Bresciani, E., Rapetti, D., Donà, F. et al. Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. J Endocrinol Invest 29, RC16–RC18 (2006). https://doi.org/10.1007/BF03344175

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  • DOI: https://doi.org/10.1007/BF03344175

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