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A rare association between malignant mediastinal seminoma and other malignant neoplasms

Journal of Endocrinological Investigation volume 25, pages 373–376 (2002)Cite this article

Abstract

Primary malignant mediastinal seminomas (PMMS) are rare tumors accounting for 1–6% of all mediastinal tumors. PMMS mostly affect young men, arising from primordial germ cells that abnormally migrate from the ectoderm of the yolk sac to the gonadal region. They are clinically and biologically distinct from primary testicular tumors and seem to have a worse prognosis. Due to the rarity of the disease, the choice of treatment is a matter of debate. Literature data do not show any association between this kind of tumor and malignant Schwannoma or thyroid carcinoma. In this report we describe the case of a patient affected by PMMS and 12 yr later by a malignant brachial plexus Schwannoma and papillary thyroid carcinoma (PTC). Since both mediastinal seminoma and Schwannoma were treated with surgery followed by local radiotherapy, we were not able to ascertain if either PTC or Schwannoma had been induced by radiotherapy or represented a casual neoplastic association.

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References

  1. Raghavan D. Malignant extragonadal germ cell tumours. In: Horwich A. (Ed.), Testicular cancer. Clinical investigation and management. Chapman and Hall Medical, London, New York, Melbourne, 1991, p. 297.

    Google Scholar 

  2. Oosterhius J.W., R.H., Cornelisse C.J., De Jong B., Dam A., Sleijfer D.T. Ploidy of malignant mediastinal germ cell tumors. Hum. Pathol. 1990, 2: 729–732.

    Article  Google Scholar 

  3. Przygodzki R.M., Moran C.A., Suster S., et al. Primary mediastinal and testicular seminomas: a comparison of k-ras-2-gene sequence and p 53 immunoperoxidase analysis of 26 cases. Hum. Pathol. 1996, 2: 975–979.

    Article  Google Scholar 

  4. Davis R.D., Oldham H.N., Sabiston D.C. Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management and results. Ann. Thorac. Surg. 1987, 44: 229–237.

    PubMed  Article  Google Scholar 

  5. Brown K., Collins J.D., Batra P. Mediastinal germ cell tumor in a young woman. Med. Pediatr. Oncol. 1989, 17: 164–167.

    CAS  PubMed  Article  Google Scholar 

  6. Nichols C.R., Roth B.J., Heerema N., Griep J., Tricot G. Hematologic neoplasia associated with primary mediastinal germ cell tumors. N. Engl. J. Med. 1990, 322: 1425–1429.

    CAS  PubMed  Article  Google Scholar 

  7. Rosado de Christenson M.L., Templeton P., Moran C.A. Mediastinal germ cell tumors: radiologic and pathologic correlation. Radiographics 1992, 12: 1013–1030.

    CAS  PubMed  Article  Google Scholar 

  8. Orazi A., Neiman R.S., Ulbright T.M., Heerema N.A., John K., Nichols C.R. Hematopoietic precursor cells within the yolk sac tumor component are the source of secondary hematopoietic malignancies in patients with mediastinal germ cell tumors. Cancer 1993, 71: 3873–3881.

    CAS  PubMed  Article  Google Scholar 

  9. Hainsworth J.D., Greco F.A. Extragonadal germ cell tumors and unrecognised germ cell tumors. Semin. Oncol. 1992, 19: 119–127.

    CAS  PubMed  Google Scholar 

  10. Toner G., Geller N., Shiow-Yun L., Bosl G. Extragonadal and poor risk nonseminomatous germ cell tumors. Cancer 1991, 67: 2049–2057.

    CAS  PubMed  Article  Google Scholar 

  11. Childs W.J., Goldstraw P., Nicholls J.E., Dearnaley D.P., Horwich A. Primary malignant mediastinal germ cell tumours: improved prognosis with platinum-based chemotherapy and surgery. Br. J. Cancer 1993, 67: 1098–1101.

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  12. Mead G.M., Stenning S.P., Parkinson M.C., et al. The second Medical Research Council Study of prognostic factors in nonseminomatous germ cell tumours. J. Clin. Oncol. 1992, 10: 85–94.

    CAS  PubMed  Google Scholar 

  13. Goss P.E., Schwertfeger L., Blackstein M.E., et al. Extragonadal germ cell tumors. A 14 year Toronto experience. Cancer 1994, 73: 1971–1979.

    CAS  PubMed  Article  Google Scholar 

  14. Dulmet E.M., Macchiarini P., Suc B., Verley J.M. Germ cell tumors of the mediastinum. A 30-year experience. Cancer 1993, 72: 1894-1901.

    Google Scholar 

  15. Bush S.E., Martinez A., Bagshaw M.A. Primary mediastinal seminoma. Cancer 1981, 48: 1877–1882.

    CAS  PubMed  Article  Google Scholar 

  16. Nichols C.R. Mediastinal germ cell tumors. Semin. Thorac. Cardiovasc. Surg. 1992, 4: 45–50.

    CAS  PubMed  Google Scholar 

  17. Ginsberg R.J. Mediastinal germ cell tumor: the role of surgery. Semin. Thorac. Cardiovasc. Surg. 1992, 4: 51–54.

    CAS  PubMed  Google Scholar 

  18. Nichols C.R. Mediastinal germ cell tumor. Chest 1991, 99:472–479.

    CAS  PubMed  Article  Google Scholar 

  19. Martini N., Golbey R.B., Hajdu S.I., Whitmore W.F., Beattie E.J. Primary mediastinal germ cell tumors. Cancer 1974, 33: 763–769.

    CAS  PubMed  Article  Google Scholar 

  20. Bosl G.J., Gluckman R., Gelle N.L., et al. VAB-6: an effective chemotherapy regimen for patients with germ-cell tumors. J.Clin. Oncol. 1986: 4: 1493–1499.

    CAS  PubMed  Google Scholar 

  21. Mc Leod D.G., Taylor H.G., Skoog S.J., Knight R.D., Dawson N.A., Waxman J.A. Extragonadal germ cell tumors. Clinicopathologic findings and treatment experience in 12 patients. Cancer 1988, 61: 1187–1191.

    CAS  Article  Google Scholar 

  22. Logothetis C.J., Samuels M.L., Selig D.E., et al. Chemotherapy of extragonadal germ cell tumors. J. Clin. Oncol. 1985, 3: 316–325.

    CAS  PubMed  Google Scholar 

  23. Ensinger F.M., Weiss S.W. Soft tissue tumors. C.V. Mosby, St. Louis, 1983.

    Google Scholar 

  24. Robbins J., Merino M.J., Boice J.D., et al. Thyroid cancer: a lethal endocrine neoplasm. Ann. Intern. Med. 1991, 115:133–147.

    CAS  PubMed  Article  Google Scholar 

  25. Jossart G.M., Clark O.H. Well-differentiated thyroid cancer. Curr. Probl. Surg. 1994, 31: 933–947.

    CAS  PubMed  Article  Google Scholar 

  26. Franceschi S., Boyle P., Maisonneuve P., et al. The epidemiology of the thyroid carcinoma. Crit. Rev. Oncog. 1993, 4: 25–52.

    CAS  PubMed  Google Scholar 

  27. Shore R.E. Issues and epidemiological evidence regarding radiation-induced thyroid cancer. Radiat. Res. 1992, 131: 98–111.

    CAS  PubMed  Article  Google Scholar 

  28. Ron E., Kleinerman R.A., Boice J.D., Li Volsi V.A., Flannery J.T., Fraumeni J.F. Jr. A population-based case control study of thyroid cancer. J. Natl. Cancer Inst. 1987, 79: 1–12.

    CAS  PubMed  Google Scholar 

  29. Schneider A.B., Recant W., Pinsky S.M., Ryo U.Y., Beckerman C., Shore Freedman. Radiation-induced thyroid carcinoma. Clinical causes and results of thyroid in 296 patients. Ann. Intern. Med. 1986, 105: 405–412.

    CAS  PubMed  Article  Google Scholar 

  30. Schneider A.B., Ron E., Lubin J., Stovall M., Gierlowski T.C. Dose-response relationships for radiation-induced thyroid cancer and thyroid nodules: evidence for the prolonged effects of radiation on the thyroid. J. Clin. Endocrinol. Metab. 1993, 77: 362–369.

    CAS  PubMed  Google Scholar 

  31. Boice J.D. Jr, Engholm G., Kleinerman R.A., et al. Radiation dose and second cancer risk in patients treated for cancer of the cervix. Radiat. Res. 1988, 116: 3–55.

    PubMed  Article  Google Scholar 

  32. Kazakov U.S., Demidchik E.P., Astakhova L.N. Thyroid cancer after Chernobyl. Nature 1992, 21: 359.

    Google Scholar 

  33. Pacini F., Vorontosova T., Demidchik E.P., et al. Post-Chernobyl thyroid carcinoma in Belarus children and adolescents: comparison with naturally occurring thyroid carcinoma in Italy and France. J. Clin. Endocrinol. Metab. 1997, 82: 3563–3569.

    CAS  PubMed  Google Scholar 

  34. Schlumberger M.J. Papillary and follicular thyroid carcinoma. N. Engl. J. Med. 1998, 338: 297–306.

    CAS  PubMed  Article  Google Scholar 

  35. Stratakis C.A., Kirschner L.S., Taymans S.E., et al. Carney complex, Peutz-Jeghers syndrome, Cowden disease and Bannayan-Zonana syndrome share cutaneous and endocrine manifestations but not genetic loci. J. Clin. Endocrinol. Metab. 1998, 83: 2972–2976.

    CAS  PubMed  Article  Google Scholar 

  36. Giardiello F.M., Welsh S.B., Hamilton S.R., et al. Increased risk of cancer in the Peutz-Jeghers Syndrome. N. Engl. J. Med. 1987, 316: 1511–1514.

    CAS  PubMed  Article  Google Scholar 

  37. Hizawa K., Iida M., Matsumoto T., et al. Cancer in Peutz-Jeghers syndrome. Cancer 1993, 72: 2777–2781.

    CAS  PubMed  Article  Google Scholar 

  38. Young S., Gooneratne S., Straus F.H., Zeller W.P., Bulun S.E, Rosenthal I.M. Feminizing Sertoli cell tumours in boys with Peutz-Jeghers syndrome. Am. J. Surg. 1995, 19: 50–58.

    CAS  Google Scholar 

  39. Liaw D., Marsh D.J., Li J., et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet. 1997, 16: 64–67.

    CAS  PubMed  Article  Google Scholar 

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Authors and Affiliations

  1. Service of Endocrinology, Regina Elena Cancer Institute - I.F.O., Via E. Chianesi 53, 00144, Rome, Italy

    M. Appetecchia

  2. Department of Endocrinology, University of Pisa, Pisa, Italy

    E. Pucci

Authors
  1. M. Appetecchia
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  2. E. Pucci
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Correspondence to M. Appetecchia.

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Appetecchia, M., Pucci, E. A rare association between malignant mediastinal seminoma and other malignant neoplasms. J Endocrinol Invest 25, 373–376 (2002). https://doi.org/10.1007/BF03344021

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  • DOI: https://doi.org/10.1007/BF03344021

Key-words

  • Mediastinal seminoma
  • extragonadal germ cell tumors
  • differentiated thyroid carcinoma
  • malignant Schwannoma
  • familial multiple neoplasia and lentiginosis syndromes