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Insulin action and secretion in healthy Hispanic-Mexican first-degree relatives of subjects with Type 2 diabetes

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Abstract

The aim of this study was to assess the early insulin secretion and insulin action of healthy non-diabetic Hispanic-Mexican subjects with and without family history of Type 2 diabetes (FHD). One hundred and twenty non-relative subjects were compared against 115 first-degree relatives of individuals with Type 2 diabetes. To assign the subjects to the correspondent group, the FHD was carefully ascertained by clinical examination of the participants’ parents. Age and gender were matched criteria. Incomplete or unclear data about FHD, previous diagnosis of diabetes or chronic diseases were exclusion criteria. Subjects in both groups were required to have fasting glucose <6.1 mmol/l, and 2-h PG<7.7 mmol/l. Insulin action and secretion were estimated by HOMA (homeostasis model insulin analysis resistance index) and insulinogenic index, respectively. Logistic regression analysis showed an independent relationship between BMI and insulin resistance (HOMA score >5.0) (odds ratio, OR, 1.42, p=0.03), and between FHD and insulin resistance (OR 1.27, p=0.04). On the other hand, there was a strong and independent relationship between FHD and high early insulin secretion (insulinogenic index ≧0.72) (OR 1.64, p=0.01) but not between BMI and high early insulin secretion (OR 0.93, p=0.3). Healthy Mexican first-degree relatives of subjects with Type 2 diabetes show an independent relationship between FHD and both high early insulin response and decreased insulin action, whereas BMI was only related to insulin resistance.

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Authors and Affiliations

  1. Medical Research Unit in Clinical Epidemiology of the Mexican Institute of Social Security (MISS), Siqueiros 225 esq./Castañeda, 34000, Durango, Dgo., Mexico

    Fernando Guerrero-Romero & M. Rodríguez-Morán

  2. Research Group on Diabetes and Chronic Illnesses, Durango, Mexico

    Fernando Guerrero-Romero & M. Rodríguez-Morán

  3. Medical Research Unit in Clinical Epidemiology, Speciality Hospital, West National Medical Center, MISS, Guadalajara, Mexico

    M. González-Ortiz & E. Martínez-Abundis

Authors
  1. Fernando Guerrero-Romero
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  2. M. Rodríguez-Morán
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  3. M. González-Ortiz
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  4. E. Martínez-Abundis
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Correspondence to Fernando Guerrero-Romero.

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Guerrero-Romero, F., Rodríguez-Morán, M., González-Ortiz, M. et al. Insulin action and secretion in healthy Hispanic-Mexican first-degree relatives of subjects with Type 2 diabetes. J Endocrinol Invest 24, 580–586 (2001). https://doi.org/10.1007/BF03343898

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