Skip to main content
SpringerLink
Log in

Skeletal effects of estrogens

  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Turner R.T., Riggs B.L., Spelsberg T.C. Skeletal effects of estrogen. Endocr. Rev. 1994, 15: 275–300.

    CAS  PubMed  Google Scholar 

  2. JAMA National Institutes of Health Consensus Conference. JAMA 1984, 252: 799–802.

    Article  Google Scholar 

  3. Richelson L.S., Wahner H.W., Melton L.J., Riggs B.L. Relative contributions of aging and estrogen deficency to postmenopausal bone loss. N. Engl. J. Med. 1984, 311: 1273–1275.

    Article  CAS  PubMed  Google Scholar 

  4. Han Z.H., Palnitkar S., Rao D.S., Nelson D., Parfitt A.M. Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: implications for mechanisms of bone loss. J. Bone Miner. Res. 1997, 12: 498–508.

    Article  CAS  PubMed  Google Scholar 

  5. Barzel U.L. Estrogens in the prevention and treatment of postmenopausal osteoporosis: a review. Am. J. Med. 1988, 85: 847–850.

    Article  CAS  PubMed  Google Scholar 

  6. Komm B.S., Terpening C.M., Benz D.J., Graeme K.A., O’Malley B.W., Haussler M.R. Estrogen binding receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science 1988, 241: 81–84.

    Article  CAS  PubMed  Google Scholar 

  7. Eriksen E.F., Colvard D.S., Berg N.J., Graham M.L., Mann K.G., Spelsberg T.C., Riggs B.L. Evidence of estrogen receptors in normal human osteoblast- like cells. Science 1988, 241: 84–86.

    Article  CAS  PubMed  Google Scholar 

  8. Smith E.P., Boyod J., Frank G.R., Talahashi H., Cohen R.M., Specker B., Williams T.C., Lubhan D.B., Korach K.S. Estrogen resistance caused by a mutation in the estrogen- receptor gene in a man. N. Engl. J. Med. 1994, 331: 1056–1061.

    Article  CAS  PubMed  Google Scholar 

  9. Korach K.S. Insights from the study of animals lacking functional estrogen receptor. Science 1994, 266: 1524–1527.

    Article  CAS  PubMed  Google Scholar 

  10. Arts J., Kuipfer G.G.J.M., Janssen J.M.M.F., Gustafsson J., Lowik C.W.G.M., Pols H.A.P., Van Leeuwen J.P.T.M. Differential expression of estrogen receptors α and gB mRNA during differentiation of the human osteoblast SV-HFO cells. Endocrinology 1997, 138: 5067–5070.

    CAS  PubMed  Google Scholar 

  11. Onoe Y., Miyaura C., Ohta H., Nozawa S., Suda T. Expression of estrogen receptor gB in rat bone. Endocrinology 1997, 138: 4509–4512.

    CAS  PubMed  Google Scholar 

  12. Delaveyne-bitbol R., Garabedian M. In vitro responses to 17gB-estradiol throughout pubertal maturation in female human bone cells. J. Bone Miner. Res. 1999, 14: 376–385.

    Article  CAS  PubMed  Google Scholar 

  13. Ernst M., Health J.K., Rodan G.A. Estradiol effects on proliferation, messenger ribonucleic acid for collagen and insulin-like growth factor-I, and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones. Endocrinology 1989, 125: 825–833.

    Article  CAS  PubMed  Google Scholar 

  14. Ernst M., Schmid C., Froesch E.R. Enhanced osteoblast proliferation and collagen gene expression by estradiol. Proc. Natl. Acad. Sci. 1988, 85: 2307–2310.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Gray T.K., Flynn T.C., Gray K.M., Namell L.M. 17gB-estradiol acts directly on the clonal osteoblastic cell line UMR106. Proc. Natl. Acad. Sci. USA 1987, 84: 6267–6271.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Keeting P.E., Scott R.E., Colvard D.S., Han I.K., Spelsberg T.C., Riggs B.L. Lack of a direct effect of estrogen on proliferation and differentiation of normal human osteoblast-like cells. J. Bone Miner. Res. 1991, 6: 297–304.

    Article  CAS  PubMed  Google Scholar 

  17. Kassem M., Okazaki R., Harris S.A., Spelsberg T.C., Conover C.A., Riggs B.L. Estrogen effects on insulin-like growth factor gene expression in a human osteoblastic cell line with high levels of estrogen receptor. Calcif. Tissue Int. 1998, 62: 60–66.

    Article  CAS  PubMed  Google Scholar 

  18. Jilka R.L. Cytokines, bone remodeling, and estrogen deficiency: a 1998 update. Bone 1998, 23: 75–81.

    Article  CAS  PubMed  Google Scholar 

  19. Pacifici R. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J. Bone Min. Res. 1996, 11: 1043–1051.

    Article  CAS  Google Scholar 

  20. Brandi M.L., Crescioli C., Tanin A., Frediani U., Agnusdei D., Gennari C. Bone endothelial cells as estrogen targets. Calcif. Tissue Int. 1993, 53: 312–317.

    Article  CAS  PubMed  Google Scholar 

  21. Jilka R.L., Hangoc G., Girasole G., Passeri G., Williams D.C., Abrams J.S., Boyce B., Broxmeyer H., Manolagas S.C. Increased osteoclast development after estrogen loss: mediation by IL-6. Science 1992, 257: 88–91.

    Article  CAS  PubMed  Google Scholar 

  22. Kimble R.B., Srivastava S., Ross F.P., Matayoski A., Pacifici R. Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin- 1- and tumor necrosis factor-mediated stimulation of machrofage colony-stimulating factor production. J. Biol. Chem. 1996, 271: 28890–28897.

    Article  CAS  PubMed  Google Scholar 

  23. Huges D.E.I Dai A., Tiffee J.C., Li H.H., Mundy G.R., Boyce B.F. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-gB. Nature Med. 1996, 2: 1132–1136.

    Article  Google Scholar 

  24. Oursler M.J., Osdoby P., Pyfferoen J.7 Riggs B.L., Spelsberg T.C. Avian osteoclasts as estrogen target cells. Proc. Natl. Acad. Sci. USA 1991, 88: 6613–6617.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Mano H., Yuasa T., Kameda T., Miyazawa K., Nakamaru Y., Shiokawa M., Mori Y., Yamada T., Miyata K., Shindo H., Azuma H., Hakeda Y., Kumegawa M. Mammalian mature osteoclasts as estrogen target cells. Biochem. Biophys. Res. Commun. 1996, 223: 637–642.

    Article  CAS  PubMed  Google Scholar 

  26. Ousler M.J., Pederson L., Fitzpatrick L., Riggs B.L. Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells. Proc. Natl. Acad. Sci. USA 1994, 91: 5227–5231.

    Article  Google Scholar 

  27. Fiorelli G., Gori F., Petilli M., Tanini A., Benvenuti S., Serio M., Bernabei P., Brandi M.L. Functional estrogen receptors in a human preosteoclastic cell line. Proc. Natl. Acad. Sci. USA 1995, 92: 2672–2676.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Kanatani M., Sugimoto T., Takahashi Y., Kaji H., Kitazawa R., Chihara K. Estrogen via the estrogen receptor blocks cAMP-mediated parathyroid hormone (PTH)-stimulated osteoclast formation. J. Bone Miner. Res. 1998, 13: 854–862.

    Article  CAS  PubMed  Google Scholar 

  29. Oursler M.J., Pederson L., Pyfferoen J., Osdoby P., Fizpatrick L., Spelsberg T.C. Estrogen modulation of avian osteoclast Iysosomal gene expression. Endocrinology 1993, 132: 1373–1380.

    CAS  PubMed  Google Scholar 

  30. Fiorelli G., Gori F., Frediani U., Morelli A.M., Falchetti A., Benvenuti S., Masi L., Brandi M.L. Evidence for bioeffects of LY139478 on the human preosteoclastic cell line FLG 29.1. Biochem. Biophys. Res. Commun. 1995, 211: 857–863.

    Article  CAS  PubMed  Google Scholar 

  31. Zecchi-Orlandini S., Formigli L., Tani A., Benvenuti S., Fiorelli G., Papucci L., Capaccioli S., Orlandini G.E., Brandi M.L. 17gB-estradiol induces apoptosis in the preosteoclastic FLG 29.1 cell line. Biochem. Biophys. Res. Commun. 1999, 255: 680–685.

    Article  CAS  PubMed  Google Scholar 

  32. Fiorelli G., Martineti V., Gori F., Benvenuti S., Frediani U., Formigli L., Zecchi S., Brandi M.L. Heterogeneity of binding sites and bioeffects of raloxifene on the human leukemic cell line FLG 29.1. Biochem. Biophys. Res. Comm. 1997,. 240: 573–579.

    Article  CAS  PubMed  Google Scholar 

  33. Paech K., Webb P., Kuiper G.J.M., Nilsson S., Gustaffson J., Kushner P.J., Canlan T.S. Differential ligand activation of estrogen receptors ERa and ERb at APl sites. Science 1997, 277: 1508–1510.

    Article  CAS  PubMed  Google Scholar 

  34. Lieberherr M., Grosse B., Kachkache M., Balsan S. Cell signaling and estrogens in female rat osteoblasts: a possible involvement of unconventional nonnuclear receptors. J. Bone Miner. Res. 1993, 8: 1365–1376.

    Article  CAS  PubMed  Google Scholar 

  35. Gay C.V., Kief N.L., Bekker P.J. Effect of estrogen on acidification in osteoclasts. Biochem. Biophys. Res. Commun. 1993, 192: 1251–1259.

    Article  CAS  PubMed  Google Scholar 

  36. Fiorelli G., Gori F., Frediani U., Franceschelli F., Tanini A., Tosti-Guerra C., Benvenuti S., Gennari L., Lucia B., Brandi M.L. Membrane binding sites and nongenomic effects of estrogen in cultured human preosteoclastic cells. J. Steroid Biochem. Mol. Biol. 1996, 59: 233–240.

    Article  CAS  PubMed  Google Scholar 

  37. Burkhardt R., Kettner G., Bohom W., Schmidmeier M., Schalg R., Frish B., Mallmann B., Eisenmenger W., Gilg T.H. Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone 1987, 8: 157–164.

    Article  CAS  PubMed  Google Scholar 

  38. Stevenson J.C., Whitehead M.I. Postmenopausal osteoporosis. Br. J. Med 1982, 282: 585–588.

    Article  Google Scholar 

  39. Morishima A., Grumbach M.M., Simpson E.R., Fisher C., Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J. Clin. Endocrinol. Metab. 1995, 80: 3689–3698.

    CAS  PubMed  Google Scholar 

  40. Vanderschueren D., Van Herck E., Nijs J., Ederveen A.G.H., De Coster R., Bouillon R. Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats. Endocrinology 1997, 138: 2301–2307.

    CAS  PubMed  Google Scholar 

  41. Jacob F., Siggelkow H., Homann D., Kohrle J., Adamski J., Schutze N. Local estradiol metabilism in osteoblast- and osteoclast- like cells. J. Steroid Biochem. Mol. Biol. 1997, 61: 167–174.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Physiopathology, Endocrine Unit, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy

    G. Fiorelli & Maria Luisa Brandi MD, PhD

Authors
  1. G. Fiorelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maria Luisa Brandi MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fiorelli, G., Brandi, M.L. Skeletal effects of estrogens. J Endocrinol Invest 22, 589–593 (1999). https://doi.org/10.1007/BF03343615

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03343615

Key-words

Search

Navigation