Following the publication of the Opinion entitled “Clinical usefulness of the low dose ACTH test” by L. Patel and P.E. Clayton (J. Endocrinol. Invest. 1999, 22, 401–404) the following paper by B. Ambrosi and L. Barbetta is another opinion on the same topic. We thank both the Authors for their kind contributions and leave to the reader the possibility to evaluate these two different points of view about the role of the low dose ACTH test. The Editor-in-Chief
References
Patel L., Clayton P.E. Clinical usefulness of the low dose ACTH test. J. Endocrinol. Invest. 1999, 22: 401–404.
Landon J., James H.T., Cryer R.J., Wynn V., Frankland A.W. Adrenocorticotropic effects of a synthetic polypeptide-β1-24-corticotropin in man. J. Clin. Endocrinol. Metab. 1964, 24: 1206–1213.
Cunningham S.K., Moore A., McKenna T.J. Normal cortisol response to corticotropin in patients with secondary adrenal failure. Arch. Intern. Med. 1983, 143: 2276–2279.
Lindholm J., Kehlet H. Re-evaluation of the clinical value of the 30 min ACTH test in assessing the hypothalamic-pituitaryadrenocortical function. Clin. Endocrinol. (Oxf.) 1987, 26: 53–59.
Hurel S.J., Thompson C.J., Watson M.J., Harris M.M., Baylis P.H., Kendall-Taylor P. The short Synacthen and insulin stress test in the assessment of the hypothalamic-pituitary adrenal axis. Clin. Endocrinol. (Oxf.) 1996, 44: 141–146.
Crowley S., Hindmarsh P.C., Holownia P., Honour J.W., Brook C.G.D. The use of low doses of ACTH in the investigation of adrenal function in man. J. Endocrinol. 1991, 130: 475–479.
Dickstein G., Arad E., Shechner C. Low-dose ACTH stimulation test. Endocrinologist 1997, 7: 285–293.
Ambrosi B., Barbetta L., Re T., Passini E., Faglia G. The one microgram adrenocorticotropin test in the assessment of hypothalamic-pituitary-adrenal function. Eur. J. Endocrinol. 1998, 139: 575–579.
Tordjman K., Jaffe A., Grazas N., Apter C., Stern N. The role of the low dose (1 μg) adrenocorticotropin test in the evaluation of patients with pituitary diseases. J. Clin. Endocrinol. Metab. 1995, 80: 1301–1305.
Rasmuson S., Olsson T., Hagg E. A low dose ACTH test to assess the function of the hypothalamo-pituitary-adrenal axis. Clin. Endocrinol. (Oxf.) 1996, 44: 151–156.
Weintrob N., Sprecher E., Josefberg Z., Weininger C., Auerbach-Klipper Y., Lazard D., Karp M., Pertzelan A. Standard and low-dose short adrenocorticotropin test compared with insulin-induced hypoglycemia of assessment of the hypothalamo-pititary-adrenal axis in children with idiopathic multiple pituitary hormone deficiencies. J. Clin. Endocrinol. Metab. 1995, 83: 88–92.
Broide J., Soferman R., Kivity S., Golander A., Dickstein G., Spirer Z., Weisman Y. Low-dose adrenocorticotropin test reveals impaired adrenal function in patients taking inhaled corticosteroids. J. Clin. Endocrinol. Metab. 1995, 4: 1243–1246.
Mayenknecht J., Diederich S., Bahr V., Plockinger U., Oelkers W. Comparison of low and high dose corticotrophin stimulation tests in patients with pituitary disease. J. Clin. Endocrinol. Metab. 1998, 83: 1558–1562.
Oelkers W. The role of high- and low-dose corticotropin tests in the diagnosis of secondary adrenal insufficiency. Eur. J. Endocrinol. 1998, 139: 567–570.
Oelkers W. Dose-response aspects in the clinical assessment of the hypothalamo-pituitary-adrenal axis, and the lowdose adrenocorticotropin test. Eur. J. Endocrinol. 1996, 135: 27–33.
Thaler L.M., Blevins L.S. The low dose (1-μg) adrenocorticotropin stimulation test in the evaluation of patients with suspected central adrenal insufficiency. J. Clin. Endocrinol. Metab. 1998, 83: 2726–2729.
Bangar V., Clayton R.N. How reliable is the short Synacthen test for the investigation of the hypothalamic-pituitary-adrenal axis? Eur. J. Endocrinol. 1998, 139: 580–583.
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Ambrosi, B., Barbetta, L. The role of the low dose ACTH test in the evaluation of central hypoadrenalism. J Endocrinol Invest 22, 492–495 (1999). https://doi.org/10.1007/BF03343596
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DOI: https://doi.org/10.1007/BF03343596