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The role of the low dose ACTH test in the evaluation of central hypoadrenalism

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Following the publication of the Opinion entitled “Clinical usefulness of the low dose ACTH test” by L. Patel and P.E. Clayton (J. Endocrinol. Invest. 1999, 22, 401–404) the following paper by B. Ambrosi and L. Barbetta is another opinion on the same topic. We thank both the Authors for their kind contributions and leave to the reader the possibility to evaluate these two different points of view about the role of the low dose ACTH test. The Editor-in-Chief

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References

  1. Patel L., Clayton P.E. Clinical usefulness of the low dose ACTH test. J. Endocrinol. Invest. 1999, 22: 401–404.

    Article  CAS  PubMed  Google Scholar 

  2. Landon J., James H.T., Cryer R.J., Wynn V., Frankland A.W. Adrenocorticotropic effects of a synthetic polypeptide-β1-24-corticotropin in man. J. Clin. Endocrinol. Metab. 1964, 24: 1206–1213.

    Article  CAS  PubMed  Google Scholar 

  3. Cunningham S.K., Moore A., McKenna T.J. Normal cortisol response to corticotropin in patients with secondary adrenal failure. Arch. Intern. Med. 1983, 143: 2276–2279.

    Article  CAS  PubMed  Google Scholar 

  4. Lindholm J., Kehlet H. Re-evaluation of the clinical value of the 30 min ACTH test in assessing the hypothalamic-pituitaryadrenocortical function. Clin. Endocrinol. (Oxf.) 1987, 26: 53–59.

    Article  CAS  Google Scholar 

  5. Hurel S.J., Thompson C.J., Watson M.J., Harris M.M., Baylis P.H., Kendall-Taylor P. The short Synacthen and insulin stress test in the assessment of the hypothalamic-pituitary adrenal axis. Clin. Endocrinol. (Oxf.) 1996, 44: 141–146.

    Article  CAS  Google Scholar 

  6. Crowley S., Hindmarsh P.C., Holownia P., Honour J.W., Brook C.G.D. The use of low doses of ACTH in the investigation of adrenal function in man. J. Endocrinol. 1991, 130: 475–479.

    Article  CAS  PubMed  Google Scholar 

  7. Dickstein G., Arad E., Shechner C. Low-dose ACTH stimulation test. Endocrinologist 1997, 7: 285–293.

    Article  Google Scholar 

  8. Ambrosi B., Barbetta L., Re T., Passini E., Faglia G. The one microgram adrenocorticotropin test in the assessment of hypothalamic-pituitary-adrenal function. Eur. J. Endocrinol. 1998, 139: 575–579.

    Article  CAS  PubMed  Google Scholar 

  9. Tordjman K., Jaffe A., Grazas N., Apter C., Stern N. The role of the low dose (1 μg) adrenocorticotropin test in the evaluation of patients with pituitary diseases. J. Clin. Endocrinol. Metab. 1995, 80: 1301–1305.

    CAS  PubMed  Google Scholar 

  10. Rasmuson S., Olsson T., Hagg E. A low dose ACTH test to assess the function of the hypothalamo-pituitary-adrenal axis. Clin. Endocrinol. (Oxf.) 1996, 44: 151–156.

    Article  CAS  Google Scholar 

  11. Weintrob N., Sprecher E., Josefberg Z., Weininger C., Auerbach-Klipper Y., Lazard D., Karp M., Pertzelan A. Standard and low-dose short adrenocorticotropin test compared with insulin-induced hypoglycemia of assessment of the hypothalamo-pititary-adrenal axis in children with idiopathic multiple pituitary hormone deficiencies. J. Clin. Endocrinol. Metab. 1995, 83: 88–92.

    Article  Google Scholar 

  12. Broide J., Soferman R., Kivity S., Golander A., Dickstein G., Spirer Z., Weisman Y. Low-dose adrenocorticotropin test reveals impaired adrenal function in patients taking inhaled corticosteroids. J. Clin. Endocrinol. Metab. 1995, 4: 1243–1246.

    Google Scholar 

  13. Mayenknecht J., Diederich S., Bahr V., Plockinger U., Oelkers W. Comparison of low and high dose corticotrophin stimulation tests in patients with pituitary disease. J. Clin. Endocrinol. Metab. 1998, 83: 1558–1562.

    Article  CAS  PubMed  Google Scholar 

  14. Oelkers W. The role of high- and low-dose corticotropin tests in the diagnosis of secondary adrenal insufficiency. Eur. J. Endocrinol. 1998, 139: 567–570.

    Article  CAS  PubMed  Google Scholar 

  15. Oelkers W. Dose-response aspects in the clinical assessment of the hypothalamo-pituitary-adrenal axis, and the lowdose adrenocorticotropin test. Eur. J. Endocrinol. 1996, 135: 27–33.

    Article  CAS  PubMed  Google Scholar 

  16. Thaler L.M., Blevins L.S. The low dose (1-μg) adrenocorticotropin stimulation test in the evaluation of patients with suspected central adrenal insufficiency. J. Clin. Endocrinol. Metab. 1998, 83: 2726–2729.

    CAS  PubMed  Google Scholar 

  17. Bangar V., Clayton R.N. How reliable is the short Synacthen test for the investigation of the hypothalamic-pituitary-adrenal axis? Eur. J. Endocrinol. 1998, 139: 580–583.

    Article  CAS  PubMed  Google Scholar 

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Ambrosi, B., Barbetta, L. The role of the low dose ACTH test in the evaluation of central hypoadrenalism. J Endocrinol Invest 22, 492–495 (1999). https://doi.org/10.1007/BF03343596

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